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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		MitfMi-Mee
microphthalmia, Massachusetts Eye and Ear Infirmary
MGI:2175885
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		MitfMi-Mee/MitfMi-Mee involves: C57BL/6 * FVB MGI:3813270
ht2
 		MitfMi-Mee/Mitf+ involves: C57BL/6 * FVB MGI:3813272
ot3
 		MitfMi-Mee/? involves: C57BL/6 * CAST * FVB MGI:3813268


Genotype
MGI:3813270
hm1
Allelic
Composition		 MitfMi-Mee/MitfMi-Mee
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-Mee mutation (1 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
impaired pupillary reflex ( J:140311 )
• dilation is not observed in the pupil at 27 days
abnormal iris pigmentation ( J:140311 )
• some pigment is observed in the iris at 27 days
abnormal lens morphology ( J:140311 )
• in one 27 day old homozygous female, iris is attached to lens
lens vacuoles ( J:140311 )
• in one 27 day old homozygous female, lens vacuoles are present
abnormal optic cup morphology ( J:140311 )
• at 27 days optic cup is observed to be larger than control
abnormal retina morphology ( J:140311 )
• in one 27 day old homozygous female, dysplasia is observed in the central retina and areas of the periphery and outer segments are missing
abnormal retina pigmentation ( J:140311 )
• in one 27 day old homozygous female no pigment appears in the retinal pigment epithelium (RPE)

pigmentation
absent coat pigmentation ( J:140311 )
• homozygotes have a white coat
abnormal iris pigmentation ( J:140311 )
• some pigment is observed in the iris at 27 days
abnormal retina pigmentation ( J:140311 )
• in one 27 day old homozygous female no pigment appears in the retinal pigment epithelium (RPE)

behavior/neurological
impaired pupillary reflex ( J:140311 )
• dilation is not observed in the pupil at 27 days

integument
absent coat pigmentation ( J:140311 )
• homozygotes have a white coat




Genotype
MGI:3813272
ht2
Allelic
Composition		 MitfMi-Mee/Mitf+
Genetic
Background		 involves: C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-Mee mutation (1 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal retina pigmentation ( J:140311 )
• heterozygotes have a solid pink retina with small areas of pigment
• by 2 months of age, pigment loss occurs in the center retina, however the periphery is normal and pigment granules can be seen in the outer segments

vision/eye
abnormal retina pigmentation ( J:140311 )
• heterozygotes have a solid pink retina with small areas of pigment
• by 2 months of age, pigment loss occurs in the center retina, however the periphery is normal and pigment granules can be seen in the outer segments




Genotype
MGI:3813268
ot3
Allelic
Composition		 MitfMi-Mee/?
Genetic
Background		 involves: C57BL/6 * CAST * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-Mee mutation (1 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
abnormal retina pigmentation ( J:140311 )
• heterozygotes exhibit a partial pink retina with variable penetrance of the phenotype (25%-90%)

vision/eye
abnormal retina pigmentation ( J:140311 )
• heterozygotes exhibit a partial pink retina with variable penetrance of the phenotype (25%-90%)




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory