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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cpb2tm1Mng
targeted mutation 1, Mariko Nagashima
MGI:2159468
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cpb2tm1Mng/Cpb2tm1Mng involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3720834


Genotype
MGI:3720834
hm1
Allelic
Composition
Cpb2tm1Mng/Cpb2tm1Mng
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cpb2tm1Mng mutation (0 available); any Cpb2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice exhibit a retardation in their fibrinolysis activity relative to wild-type mice (J:73713)
• following treatment with bleomycin, coagulation and fibrinolysis system activity and is decreased relative to in wild-type mice (J:107340)
• following treatment with bleomycin, levels of lactate dehydrogenase do not increase as much as in wild-type mice
• following treatment with bleomycin, levels of monocyte chemoattractant-1 (MCP-1) are decreased relative to in wild-type mice
• following treatment with bleomycin, levels of tumor necrotic factor-alpha (TNF-alpha) are decreased relative to in wild-type mice
• following treatment with bleomycin, the total number of lymphocytes and neutrophils is decreased relative to in wild-type mice and mice exhibit less lung injury
• following treatment with bleomycin, levels of monocyte chemoattractant-1 (MCP-1), tumor necrotic factor-alpha (TNF-alpha), and lactate dehydrogenase are decreased
• following treatment with bleomycin, coagulation and fibrinolysis system activity is decreased relative to in wild-type mice
• following treatment with bleomycin, collagen and fibrin deposition in the lungs is reduced relative to in wild-type mice

immune system
• following treatment with bleomycin, levels of monocyte chemoattractant-1 (MCP-1) are decreased relative to in wild-type mice
• following treatment with bleomycin, levels of tumor necrotic factor-alpha (TNF-alpha) are decreased relative to in wild-type mice

respiratory system
• following treatment with bleomycin, collagen deposition in the lungs is reduced relative to in wild-type mice





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last database update
11/14/2017
MGI 6.11
The Jackson Laboratory