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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sp7tm1Crm
targeted mutation 1, Benoit de Crombrugghe
MGI:2159411
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sp7tm1Crm/Sp7tm1Crm involves: 129S7/SvEvBrd * C57BL/6 MGI:3029315
cn2
Sox9tm3(cre)Crm/Sox9+
Sp7tm1Crm/Sp7tm2Crm
involves: 129S7/SvEvBrd * C57BL/6 * SJL MGI:3610909


Genotype
MGI:3029315
hm1
Allelic
Composition
Sp7tm1Crm/Sp7tm1Crm
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sp7tm1Crm mutation (0 available); any Sp7 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• animals die within 15 minutes of birth

homeostasis/metabolism
• animals rapidly become cyanotic after birth

limbs/digits/tail
• mice exhibit a severe inward bending of the limbs

respiratory system
• animals exhibit difficulty in breathing after birth

skeleton
• ribs are often bent and deformed
• vertebrae are often bent and deformed
• no mineralization is detectable in various bones of E15.5 embryos; bone trabeculae are frequently absent and mesenchymal cells are present at these locations




Genotype
MGI:3610909
cn2
Allelic
Composition
Sox9tm3(cre)Crm/Sox9+
Sp7tm1Crm/Sp7tm2Crm
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox9tm3(cre)Crm mutation (1 available); any Sox9 mutation (25 available)
Sp7tm1Crm mutation (0 available); any Sp7 mutation (13 available)
Sp7tm2Crm mutation (1 available); any Sp7 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die in the immediate postnatal period due to the absence of bones

skeleton
• limb skeletons are hypoplastic, bent, and often deformed
• ribs are bent and deformed
• vertebrae are bent and deformed
• endochondral skeletal elements such as the humerus have no bone trabeculae or bone collars
• osteoblast differentiation is arrested
• exhibit a decrease in endochondral and intramembranous ossification
• skeletal elements formed by endochondral bone formation, including the ribs, limb skeletons, and vertebrae are hypoplastic, bent, and often deformed
• virtually no mineralization in any facial and skull bones generated by intramembranous bone formation, although very small parts of the maxilla, mandible, and parietal bones were calcified

limbs/digits/tail
• limb skeletons are hypoplastic, bent, and often deformed

cellular
• osteoblast differentiation is arrested





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/16/2021
MGI 6.16
The Jackson Laboratory