Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1Yuan mutation
(1 available);
any
Casp4 mutation
(30 available)
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immune system
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• bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS do not show induction of IL-1beta secretion
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• bone marrow derived macrophages primed with Pam3CSK4 and transfected with LPS do not show induction of IL-18 secretion
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp4tm1Yuan mutation
(1 available);
any
Casp4 mutation
(30 available)
|
|
|
immune system
|
• decreased levels of serum IL-1alpha after lipopolysaccharide stimulation
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• decreased levels of serum IL-1beta after lipopolysaccharide stimulation
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• resistance to septic shock following LPS injection
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homeostasis/metabolism