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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Neurog3tm1Fgu
targeted mutation 1, Francois Guillemot
MGI:2159017
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Neurog3tm1Fgu/Neurog3tm1Fgu involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:3809578
cn2
Neurog3tm1Fgu/Neurog3tm3Ggr
Tg(Vil-cre)20Syr/0
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL MGI:4460260


Genotype
MGI:3809578
hm1
Allelic
Composition
Neurog3tm1Fgu/Neurog3tm1Fgu
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1Fgu mutation (0 available); any Neurog3 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die 2 to 3 days after birth

digestive/alimentary system
• unlike in wild-type mice, exocrine cells exhibit abnormal polarity and random nuclei positions
• accumulation of zymogen granules in acinar cells

homeostasis/metabolism
• 2 days after birth

growth/size/body
• 2 days after birth, mice exhibit decreased weight and dehydration compared to wild-type mice

endocrine/exocrine glands
• unlike in wild-type mice, exocrine cells exhibit abnormal polarity and random nuclei positions
• accumulation of zymogen granules in acinar cells
• at E15.5, mice lack glucagon expressing cells unlike in wild-type mice
• at E15.5, mice lack insulin expressing cells unlike in wild-type mice
• mice lack Langerhans islets at birth
• however, absence of endocrine precursors in the pancreas is not due to increased apoptosis

renal/urinary system




Genotype
MGI:4460260
cn2
Allelic
Composition
Neurog3tm1Fgu/Neurog3tm3Ggr
Tg(Vil-cre)20Syr/0
Genetic
Background
involves: 129S2/SvPas * C57BL/6 * CD-1 * DBA/2 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Neurog3tm1Fgu mutation (0 available); any Neurog3 mutation (13 available)
Neurog3tm3Ggr mutation (0 available); any Neurog3 mutation (13 available)
Tg(Vil-cre)20Syr mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Loss of enteroendocrine cells in Neurog3tm1Fgu/Neurog3tm3Ggr Tg(Vil-cre)20Syr/0 and Neurog3tm3Ggr/Neurog3tm3Ggr Tg(Vil-cre)20Syr/0 mice

mortality/aging
• 50% of mice die within the first 8 days of life

digestive/alimentary system
• at E19.5, crypt cell proliferation is increased compared to in wild-type mice
• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice
• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice
• however, intestinal epithelial cell proliferation is normal
• as early as embryogenesis, mice lack enteroendocrine progenitors along the proximal-distal axis of the intestine unlike in wild-type mice
• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice
• goblet cells in the large intestine are larger than in wild-type mice and mostly devoid of mucus
• however, goblet cell numbers are normal in the small intestine
• the large intestine exhibits a reduction in the length of glands of up to 1.5 times compared with wild-type mice
• villi are blunted or club shaped with frequent dilation and strong detachment of the epithelium from the basement membrane unlike in wild-type mice
• microvilli on absorptive cells are sparser, 60% shorter, but twice as large as on wild-type cells
• the brush border of absorptive cells in the small intestine is reduced 44% compared to in wild-type mice
• however, expression of brush border enzymes and glucose transporters is normal
• 60% shorter than in wild-type mice
• mice produce more feces compared with wild-type mice
• surviving mice exhibit soft stool that does not cease with age unlike in wild-type mice
• mice excrete yellowish stool unlike wild-type mice
• intestinal transit time is increased 2.3-fold compared to in wild-type mice

homeostasis/metabolism
• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice
• fasting mice exhibit decreased blood glucose compared with similarly treated wild-type mice
• in an oral glucose tolerance test, mice exhibit improved glucose clearance compared with similarly treated wild-type mice
• in an intraperitoneal glucose tolerance test, mice exhibit lower serum glucose levels than in similarly treated wild-type mice
• slightly at 14 and 17 weeks
• insulin-mediated hypoglycemic response is blunted compared to in wild-type mice

growth/size/body

adipose tissue
• mice exhibit reduced abdominal fat compared with wild-type mice

endocrine/exocrine glands
• small intestine crypts are disorganized, larger, and more abundant than in wild-type mice
• mice exhibit more medium and large islets with centrally located alpha cells than in wild-type mice
• mice exhibit a shift from large to single islets compared with wild-type mice

cellular
• at E19.5, crypt cell proliferation is increased compared to in wild-type mice
• in adult mice, crypt cell proliferation is increased with an up to 1.6-fold increase in cell turnover compared to in wild-type mice





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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory