Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation
(2 available);
any
Cnga2 mutation
(15 available)
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mortality/aging
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• mice die within 2 days of birth unless normal littermates are removed thereby reducing competition for milk
• however, if normal littermates are removed mice survive into adulthood
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taste/olfaction
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• olfactory neurons are not responsive to forskolin
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growth/size/body
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• mice fail to thrive after birth
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nervous system
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• olfactory neurons are not responsive to forskolin
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nervous system
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• Hyb B and Hyb D axons segregate into separate into separate compartments within the same glomeruli
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nervous system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb
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craniofacial
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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respiratory system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
taste/olfaction
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
growth/size/body
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
nervous system
 |
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• Olfr160+ glomeruli are localized more ventrally than in wild-type mice
• at day 7, extra minor glomeruli are observed
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or to continue to grow past the glomerulus layer into the deep layers of the bulb
|
craniofacial
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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respiratory system
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• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
taste/olfaction
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
|
growth/size/body
|
|
• mice have more and shorter olfactory neuron axonal projections per bulb (2-9 Olfr160+ glomeruli per bulb with a mean length of 41um compared to 2-4 Olfr160+ glomeruli per bulb with a mean length of 72 um in wild-type mice)
• at day 7, Olfr160+ axons are often observed to enter inappropriate glomeruli or continue to grow past the glomerulus layer into the deep layers of the bulb
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nervous system
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• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent
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taste/olfaction
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• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent
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respiratory system
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• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent
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nervous system
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• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent
|
taste/olfaction
|
|
• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent
|
respiratory system
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• although type B olfactory sensory neurons respond normally to either KCl or reduced oxygen, responses to 8-bromo-cGMP are absent
|
taste/olfaction
|
|
• olfactory neurons are not responsive to forskolin
|
nervous system
|
|
• olfactory neurons are not responsive to forskolin
|
taste/olfaction
|
|
• olfactory neurons are not responsive to forskolin
|
nervous system
|
|
• olfactory neurons are not responsive to forskolin
|
nervous system
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• S100A5 driven GFP fluorescence is nearly undetectable in odorant stimulated olfactory sensory neurons null for CNGA2 indicating that CNGA2 is required for activation of S100A5
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taste/olfaction
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• S100A5 driven GFP fluorescence is nearly undetectable in odorant stimulated olfactory sensory neurons null for CNGA2 indicating that CNGA2 is required for activation of S100A5
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respiratory system
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• S100A5 driven GFP fluorescence is nearly undetectable in odorant stimulated olfactory sensory neurons null for CNGA2 indicating that CNGA2 is required for activation of S100A5
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Allelic
Composition |
Cnga2tm1Mom/Y
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnga2tm1Mom mutation
(2 available);
any
Cnga2 mutation
(15 available)
|
|
|
mortality/aging
|
|
• mice die within 2 days of birth unless normal littermates are removed thereby reducing competition for milk
• however, if normal littermates are removed mice survive into adulthood
|
taste/olfaction
|
|
• olfactory neurons are not responsive to forskolin
|
growth/size/body
|
|
• mice fail to thrive after birth
|
nervous system
|
|
• olfactory neurons are not responsive to forskolin
|
Analysis Tools