Phenotypes associated with this allele

• Allele Symbol: Oprm1^tm1Lyu
• Allele Name: targeted mutation 1, Lei Yu
• Allele ID: MGI:2159002
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Oprm1^tm1Lyu/Oprm1^tm1Lyu	involves: Black Swiss	MGI:3845908
ht2	Oprm1^tm1Lyu/Oprm1^+	involves: Black Swiss	MGI:3845909

Genotype
MGI:3845908

hm1

• Allelic Composition: Oprm1^tm1Lyu/Oprm1^tm1Lyu
• Genetic Background: involves: Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

oligozoospermia ( J:39864 )

♂

asthenozoospermia ( J:39864 )

♂

decreased litter size ( J:39864 )

• males sire smaller litters

reduced male fertility ( J:39864 )

♂ • sire smaller litters and the time needed to produce a pregnancy is longer

behavior/neurological

impaired behavioral response to morphine ( J:39864 )

• morphine fails to induce increased horizontal activity levels or reduced vertical activity levels

increased vertical activity ( J:39864 )

• morphine fails to induced reduced vertical activity levels unlike in wild-type mice

• however, untreated vertical activity levels are similar to wild-type controls

decreased locomotor activity ( J:39864 )

• reduced spontaneous locomotor activity

• morphine fails to induced increased horizontal activity levels

decreased chemically-elicited antinociception ( J:39864 )

• fail to show a morphine induced increase in tail flick latency

reduced male mating frequency ( J:39864 )

♂ • latency to mounting is increased and the number of appropriate mounts is decreased

♂ • the number of intromissions during each test session is significantly reduced

♂ • in a 2 hr test males fail to produce seminal plugs however, males can produce seminal plugs when left overnight with a female

♂ • however, total contact time with the female is not reduced

hematopoietic system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

abnormal common myeloid progenitor cell morphology ( J:39864 )

• increase in the number of granulocyte-macrophage (CFU-GM) and multipotential (CFU-GEMM) progenitors in the femoral bone marrow

increased erythroid progenitor cell number ( J:39864 )

• increase in the number of erythroid progenitors in the femoral bone marrow

abnormal bone marrow cell physiology ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the femoral bone marrow

immune system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

cellular

oligozoospermia ( J:39864 )

♂

asthenozoospermia ( J:39864 )

♂

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

Genotype
MGI:3845909

ht2

• Allelic Composition: Oprm1^tm1Lyu/Oprm1⁺
• Genetic Background: involves: Black Swiss

behavior/neurological

impaired behavioral response to morphine ( J:39864 )

• morphine fails to induce increased horizontal activity levels or reduced vertical activity levels

increased vertical activity ( J:39864 )

• morphine fails to induced reduced vertical activity levels unlike in wild-type mice

• however, untreated vertical activity levels are similar to wild-type controls

decreased locomotor activity ( J:39864 )

• reduced spontaneous locomotor activity compared to wild-type controls but activity levels are higher than in homozygous null mice

• morphine fails to induced increased activity levels

reduced male mating frequency ( J:39864 )

♂ • in a 2 hr test males fail to produce seminal plugs however, males can produce seminal plugs when left overnight with a female

hematopoietic system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

abnormal bone marrow cell physiology ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the femoral bone marrow

immune system

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen

cellular

increased splenocyte proliferation ( J:39864 )

• the percentage of progenitor cells in S-phase is increased in the spleen