Analysis Tools
growth/size/body
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• homozygotes are smaller than wild-type littermates
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• at 4 weeks of age, body weight of null mice is about half that of wild-type littermates
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nervous system
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• premature entry of sacral neural crest-derived cells into hindgut of mutants
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• shape of the sympathetic chain in nulls is disrupted with the cell bodies scattered in clumps over a larger area
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• mutants have a decreased number of glomeruli than wild-type: mutants have 81% of the number of glomeruli of wild-type; glomeruli numbers tend to decrease from the dorsal surface of the mutant olfactory bulb
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• olfactory bulb of mutants is smaller than in wild-type
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• most axons of the trigeminal, facial and glossopharyngeal nerves extend toward their targets, but along the way spread and individual axons project aberrantly
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• in homozygotes, the vagus and accessory nerves spread out and occupy a wider area than the tightly bundled nerves of wild-type
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• in nulls, most axons leave the DRG from the lateral side and directly innervate the dorsal muscles
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• spinal nerves of homozygotes grow over the cartilage in the forelimb to enter the basal part of the handplate unlike wild-type nerves which avoid the cartilage
• on the dorsal surface of the embryo, the spinal nerves of null embryos do not stop at the boundary of the sclerotome and sometimes cross the dorsal midline
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immune system
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• defective T-cell priming by antigen
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• impaired dendritic cell migration
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hematopoietic system
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• defective T-cell priming by antigen
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