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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptprstm1Mtr
targeted mutation 1, Michel L Tremblay
MGI:2158757
Summary 9 genotypes


Genotype
MGI:3852633
hm1
Allelic
Composition
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
B6.Cg-Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• about two-thirds of the mice die before 4 weeks of age




Genotype
MGI:3622901
hm2
Allelic
Composition
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
involves: 129/Sv * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 41% of null animals born to homozygous parents die in the first day of life; from heterozygous crosses, nulls are born at Mendelian ratios

growth/size/body
• at birth, weight of homozygotes is 5-15% lower than wild-type in heterozygous matings
• growth retardation is apparent at 3 weeks of age with homozygotes being 50-55% of normal weight in heterozygous matings

endocrine/exocrine glands
• E13-14 embryos display a moderate reduction in size of the pituitary gland; in newborns, the anterior and posterior lobes are reduced in size with the a deep open lumen being retained by the posterior lobe

nervous system
• E13-14 embryos display a moderate reduction in size of the pituitary gland; in newborns, the anterior and posterior lobes are reduced in size with the a deep open lumen being retained by the posterior lobe
• brains of adult mutants are smaller than wild-type (0.41g versus 0.49g respectively)
• olfactory bulb is reduced in size in mutants

reproductive system
• adult mutant females are rarely in oestrus
• average litter per breeding pair per month is 5 times smaller than wild-type

taste/olfaction
• mutants are hyposmic and less sensitive to repellent odors

homeostasis/metabolism
• null mice have 25-40% of wild-type levels of IGF-1




Genotype
MGI:3622904
hm3
Allelic
Composition
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
involves: BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• in mutants, significantly more neurons from null animals extend tau-positive neurites that are longer than 30 microns than do wild-type axons
• injured facial axons in mutants regenerate at a faster rate than in wild-type; functional recovery begins about 1 day earlier in mutants and full recovery occurs 1 day earlier than in wild-type animals

cellular
• in mutants, significantly more neurons from null animals extend tau-positive neurites that are longer than 30 microns than do wild-type axons




Genotype
MGI:5462106
hm4
Allelic
Composition
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• strong inhibition of neuron growth when challenged with high concentrations of chondroitin sulfate proteoglycans




Genotype
MGI:4839393
cx5
Allelic
Composition
Ptprdtm1Yiw/Ptprdtm1Yiw
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (23 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mutants are viable to late embryogenesis E18.5, born but never breathe

skeleton
• E18.5 skeletal muscle fibers are smaller in diameter, with their nuclei centrally localized along the fiber

behavior/neurological

respiratory system
• alveoli of E18.5 are tightly compressed

adipose tissue
• subcutaneous tissues are enlarged
• the compartmentalization of brown adipose tissue is less obvious

muscle
• in E18.5 skeletal muscle fibers
• at E16.5 the mean thickness of the diaphragm is thinner
• a reduction in the mass of dorsal axial skeletal muscles and limb muscles

nervous system
• only a few morphologically abnormal motoneurons that exhibit a smaller cytoplasm with Nissl bodies and an indistinct nucleolus, are found
• a decrease occurs late in embryogenesis between E13 and E18.5, during motoneuron axon extension
• at E13.5 although the phrenic nerve appears to reach the appropriate initial location on the diaphragm, the two main sternocostal branches that normally defasciculate from the main nerve are retracted
• at 15.5 and E18.5 complete absence of sternocostal branches

integument
• subcutaneous tissues are enlarged
• hair follicles are not fully developed at E18.5
• from E15




Genotype
MGI:4839394
cx6
Allelic
Composition
Ptprdtm1Yiw/Ptprdtm1Yiw
Ptprstm1Mtr/Ptprs+
Genetic
Background
B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (23 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• capillaceous nerves are seldom observed to defasciculate from the major sternocostal branches




Genotype
MGI:4839395
cx7
Allelic
Composition
Ptprdtm1Yiw/Ptprd+
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
B6.Cg-Ptprdtm1Yiw Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprdtm1Yiw mutation (1 available); any Ptprd mutation (23 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• a modest reduction of the number of motoneurons
• capillaceous nerves are seldom observed to defasciculate from the major sternocostal branches




Genotype
MGI:3852634
cx8
Allelic
Composition
Ptprftm1Wjh/Ptprftm1Wjh
Ptprstm1Mtr/Ptprstm1Mtr
Genetic
Background
B6.Cg-Ptprftm1Wjh Ptprstm1Mtr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprftm1Wjh mutation (0 available); any Ptprf mutation (19 available)
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Craniofacial anomalies in Ptprftm1Wjh/Ptprftm1Wjh Ptprstm1Mtr/Ptprstm1Mtr double-mutant embryos

mortality/aging
• all mice are dead prior to 4 weeks of age

renal/urinary system
• 13% of E18.5 embryos have duplicated kidneys and ureters
• some embryos have abnormal winding of the ureters
• common nephric duct is still present in E13.5 embryos while being eliminated in control embryos
• the common nephric duct in E12.5 embryos has much lower rates of apoptosis especially in the cadual segment where 51% of the wil-type cells are apoptotic versus 6% in the mutant embryos
• many E18.5 embryos without severe kidney malformations have dilated ureters
• 13% of E18.5 embryos have duplicated kidneys and ureters
• 52% of E18.5 embryos have severe uni- or bilateral hydroureters
• in severe hydroureter/hydronephrosis cases, a ureterocele is seen within the bladder, ipsilateral to the enlarged ureter and kidneys

craniofacial
• 45% of E18.5 embyros have micrognathia
• cleft palate is noted in E18.5 embryos
• palatal shelves extend to the midline but do not touch and fuse (Fig. 1e)

nervous system
• 23% of E18.5 embryos have exencephaly

digestive/alimentary system
• cleft palate is noted in E18.5 embryos
• palatal shelves extend to the midline but do not touch and fuse (Fig. 1e)

skeleton
• 45% of E18.5 embyros have micrognathia

vision/eye
• hyaloids arteries are observed in E18.5 embryos
• 23% of E18.5 embryos have failure in eyelid closure
• neuroretinal structures are disorganized in E18.5 embryos
• the inner nuclear layer of E18.5 embryos is hyperplastic

growth/size/body
• cleft palate is noted in E18.5 embryos
• palatal shelves extend to the midline but do not touch and fuse (Fig. 1e)




Genotype
MGI:5462104
cx9
Allelic
Composition
Ptprstm1Mtr/Ptprstm1Mtr
Rtn4rtm1.1Pado/Rtn4rtm1.1Pado
Rtn4rl1tm1.1Rojg/Rtn4rl1tm1.1Rojg
Genetic
Background
involves: 129S/SvEvBrd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptprstm1Mtr mutation (0 available); any Ptprs mutation (10 available)
Rtn4rl1tm1.1Rojg mutation (0 available); any Rtn4rl1 mutation (8 available)
Rtn4rtm1.1Pado mutation (0 available); any Rtn4r mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• considerably improved recovery of retinal ganglion cell axons from retro-orbital optic nerve crush





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory