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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Casp1tm1Flv
targeted mutation 1, Richard Flavell
MGI:2158744
Summary 10 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Casp1tm1Flv/Casp1tm1Flv involves: 129S2/SvPas * C57BL/6N MGI:6452824
ht2
Casp1tm1Flv/Casp1+ involves: 129S2/SvPas * C57BL/6N MGI:6452825
cx3
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
B6.129S2-Casp1tm1Flv MGI:3711186
cx4
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1s/Slc11a1s
B6.129S2-Casp1tm1Flv MGI:3722759
cx5
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1r/Slc11a1r
involves: 129S2/SvPas MGI:3722760
cx6
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
involves: 129S2/SvPas MGI:4839914
cx7
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Il1r1tm1Imx/Il1r1tm1Imx
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6 MGI:2179470
cx8
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
involves: 129S2/SvPas * C57BL/6 MGI:2179469
cx9
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
involves: 129S2/SvPas * C57BL/6J MGI:5467384
cx10
Casp1tm1Flv/Casp1tm1Flv
St18tm1c(KOMP)Wtsi/St18tm1c(KOMP)Wtsi
involves: C57BL/6 * C57BL/6N * DBA/2 MGI:6489911


Genotype
MGI:6452824
hm1
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• normal body weight after inducing persistent hyperglycemia in uninephrectomized mice

homeostasis/metabolism
• no albuminuria after inducing persistent hyperglycemia in uninephrectomized mice
• normal blood glucose level after inducing persistent hyperglycemia in uninephrectomized mice

renal/urinary system
N
• normal mesangial matrix after inducing persistent hyperglycemia in uninephrectomized mice




Genotype
MGI:6452825
ht2
Allelic
Composition
Casp1tm1Flv/Casp1+
Genetic
Background
involves: 129S2/SvPas * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
N
• normal body weight after inducing persistent hyperglycemia in uninephrectomized mice

homeostasis/metabolism
N
• normal blood glucose level after inducing persistent hyperglycemia in uninephrectomized mice
• no albuminuria after inducing persistent hyperglycemia in uninephrectomized mice

renal/urinary system
N
• normal mesangial matrix after inducing persistent hyperglycemia in uninephrectomized mice




Genotype
MGI:3711186
cx3
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
B6.129S2-Casp1tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• reduced compared to controls after LPS induced acute kidney failure but not significantly

renal/urinary system
• reduced compared to controls after LPS induced acute kidney failure but not significantly
• reduced after LPS induced acute kidney failure but less than in controls
• LPS induced acute kidney failure is also less severe

digestive/alimentary system
• mice and co-housed wild-type mice exhibit expanded bacterial phylotypes compared with wild-type mice
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice

immune system
• mice exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis compared with similarly treated wild-type mice
• mice transmit increased susceptibility to DSS-induced colitis to co-housed wild-type mice
• in LPS-primed bone marrow derived macrophages stimulated by S. typhimurium




Genotype
MGI:3722759
cx4
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1s/Slc11a1s
Genetic
Background
B6.129S2-Casp1tm1Flv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
Slc11a1s mutation (0 available); any Slc11a1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice

immune system
• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption
• when infected with 105 Salmonella typhimurium, mice exhibit increased mortality compared to wild-type mice
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased to a greater extent than in either single allele homozygote
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1s homozygotes

digestive/alimentary system
• the ceca of mice infected with Salmonella typhimurium and treated with streptomycin exhibit increased inflammation with more edema, more neutrophil infiltration and epithelial disruption




Genotype
MGI:3722760
cx5
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Slc11a1r/Slc11a1r
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
Slc11a1r mutation (2 available); any Slc11a1 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1r homozygotes

immune system
• when infected with 106 Salmonella typhimurium, mice have a shorter time to death than Slc11a1 homozygotes
• when infected with 106 Salmonella typhimurium, spleen and mesenteric lymph nodes bacterial loads are increased relative to in Slc11a1 homozygotes
• following infection with Salmonella typhimurium, Peyer patches exhibit slightly increased bacterial load compared to in Slc11a1r homozygotes




Genotype
MGI:4839914
cx6
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• only 3 of 16 mice injected with B16M cells die after 12 days compared to all similarly treated wild-type mice

neoplasm
• mice injected with B16 cells exhibit reduced metastasis (by volume and density) in the liver compared with similarly treated wild-type mice
• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice
• mice injected with B16 cells exhibit decreased metastasis volume, an indicator of metastatic growth, compared with similarly treated wild-type mice




Genotype
MGI:2179470
cx7
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Il1r1tm1Imx/Il1r1tm1Imx
Genetic
Background
involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
Il1r1tm1Imx mutation (4 available); any Il1r1 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• resistance to endotoxin shock induced by high dose lipopolysaccharide (LPS)




Genotype
MGI:2179469
cx8
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• Fas mediated apoptosis in thymocytes is suppressed
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired
• serum levels are reduced in mice given Il12 daily
• significantly reduced levels of Ifn gamma are induced by Il12 in splenocytes
• no Il1 alpha is released by monocytes in response to LPS
• no Il1 beta is released by monocytes in response to LPS
• significantly lower levels of Il18 are released by cultured splenocytes
• Il12 treatment fails to cause increased Il18 release but liver and spleen levels increase comparable to controls
• secretion by monocytes in response to LPS is reduced
• secretion by monocytes in response to LPS is reduced
• 10 fold increase in survival (from 6% in wild-type to 60%) of mice challenged with a high dose of LPS
• macrophages infected with Legionella and cultured for 72 hours show a 200-fold increase in bacterial number

renal/urinary system
• reduced after ischemic reperfusion as compared to controls
• ischemic acute renal failure is less severe than in controls

homeostasis/metabolism
• serum levels are reduced in mice given Il12 daily

hematopoietic system
• Fas mediated apoptosis in thymocytes is suppressed
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

cellular
• Fas mediated apoptosis in thymocytes is suppressed
• reduced after ischemic reperfusion as compared to controls
• following stimulation with monosodium urate (MSU) and calcium pyrophosphate dihydrate (CPPD), neutrophil recruitment is impaired

endocrine/exocrine glands
• Fas mediated apoptosis in thymocytes is suppressed




Genotype
MGI:5467384
cx9
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
Casp4del/Casp4del
Genetic
Background
involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
Casp4del mutation (4 available); any Casp4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice

integument
N
• untreated or TPA, TNF or EGF-treated keratinocytes exhibit normal proliferation

homeostasis/metabolism
• mice treated with 7,12-Dimethylbenz(a)anthracene/12-O-Tetradecanoylphorbol-13-acetate (DMBA) exhibit later onset and a lower incidence of tumors compared with type mice




Genotype
MGI:6489911
cx10
Allelic
Composition
Casp1tm1Flv/Casp1tm1Flv
St18tm1c(KOMP)Wtsi/St18tm1c(KOMP)Wtsi
Genetic
Background
involves: C57BL/6 * C57BL/6N * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Casp1tm1Flv mutation (2 available); any Casp1 mutation (31 available)
St18tm1c(KOMP)Wtsi mutation (0 available); any St18 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• reduced survival rates after LPS injection





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory