All Phenotypes Ciita<tm1Jpyt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ciita^tm1Jpyt
targeted mutation 1, Jenny P Y Ting
MGI:2158705

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ciita^tm1Jpyt/Ciita^tm1Jpyt	B6.129P2-Ciita^tm1Jpyt	MGI:3851337
hm2	Ciita^tm1Jpyt/Ciita^tm1Jpyt	involves: 129P2/OlaHsd * C57BL/6J	MGI:3851334

Allelic Composition	Ciita^tm1Jpyt/Ciita^tm1Jpyt
Genetic Background	B6.129P2-Ciita^tm1Jpyt

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciita^tm1Jpyt mutation (0 available); any Ciita mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T-helper 1 physiology ( J:125654 )

• Th1 response to MOG is reduced compared to in similarly treated wild-type mice with reduced frequency of cytokine-producing cells and increased antibody concentration required for activation

• splenic Th1 response is reduced compared to in wild-type mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:125654 )

• whether MOG-primed or adoptively transferred with MOG-specific T blasts, mice fail to develop symptoms of experimental autoimmune encephalomyelitis unlike wild-type mice

hematopoietic system

abnormal T-helper 1 physiology ( J:125654 )

• Th1 response to MOG is reduced compared to in similarly treated wild-type mice with reduced frequency of cytokine-producing cells and increased antibody concentration required for activation

• splenic Th1 response is reduced compared to in wild-type mice

Allelic Composition	Ciita^tm1Jpyt/Ciita^tm1Jpyt
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ciita^tm1Jpyt mutation (0 available); any Ciita mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased double-positive T cell number ( J:57100 )

• slightly in the thymus

abnormal T cell subpopulation ratio ( J:57100 )

• reduction in CD4+ T cells is accompanied by a compensatory up-regulation of CD8+ T cells

decreased CD4-positive, alpha-beta T cell number ( J:57100 )

• in the thymus and spleen

increased CD8-positive, alpha-beta T cell number ( J:57100 )

• in the spleen

decreased IgG level ( J:57100 )

• severe

increased IgM level ( J:57100 )

• slight