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Allele Symbol Allele Name Allele ID |
C3tm1Hrc targeted mutation 1, Harvey R Colten MGI:2158703 |
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| Summary |
11 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• hepatocyte proliferation is reduced and removal of necrotic and apoptotic cells is impaired after CCl4 treatment
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• mice treated with collagen antibodies do not exhibit C43 or C5a depositions compared unlike similarly treated wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a 2000-fold increase in pneumococci is seen compared to wild-type littermates following infection with S. pneumoniae
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| complement component 3 deficiency | DOID:8354 |
OMIM:613779 |
J:56193 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mutants consume 30% more calories compared to wild-type mice
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• muscle and liver uptake of labeled oleate is increased after fat loading however brown adipose tissue oleate uptake is decreased
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• muscle and liver uptake of labeled oleate is increased after fat loading however brown adipose tissue oleate uptake is decreased
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• insulin levels are decreased relative to glucose compared to wild-type mice
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• in males non-esterified fatty acid clearance is delayed relative to wild-type mice after fat administration
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• triglyceride clearance is delayed in mutants backcrossed onto a 129/Sv background but not a C57BL/6 background
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• a significant increase in capsular BAT is seen on high and low fat diets in male mutants compared to wild-type
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• on a high or low fat diet female mutants have decreased white adipose tissue
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• a small but significant decrease in adipose tissue mass particularly in the gonadal and perirenal fat is seen in male mutants
(J:58966)
• on a high or low fat diet total body fat is decreased by 40% or 59%, respectively, in female mutants
(J:60633)
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• mild polyphagia is seen in male mutants
(J:58966)
• on a high fat diet a marked increase in food intake is seen in female mutants compared to wild-type littermates
(J:60633)
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• on a high or low fat diet female mutants weigh less than wild-type littermates
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• relative to body weight leptin levels are reduced in male mutants
(J:58966)
• on a high or low fat diet, relative to body weight leptin levels are reduced in female mutants
(J:60633)
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• male mutants require a greater caloric intake relative to body weight gained compared to wild-type littermates
(J:58966)
• the average calorie intake/g increase in body weight is greater in female mutants on either a high or low fat diet
(J:60633)
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• at any given insulin level the corresponding glucose level is significantly lower in male mutants compared to wild-type on a high fat diet
(J:58966)
• glucose levels and the glucose level for any given insulin level are significantly decreased in female mutants
(J:60633)
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• insulin levels are significantly decreased in female mutants
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• on a high fat diet postprandial plasma non-esterified fatty acid levels are increased 2.5 fold compared to male mutants on a low fat diet and no such increase was seen in wild-type littermates
(J:58966)
• after 4 months on a low fat or high fat diet a greater increase in non-esterified fatty acid levels is seen in male mutants compared to wild-type mice
(J:58966)
• postprandial but not fasting non-esterified fatty acid levels are increased in female mutants especially at 26 weeks of age
(J:60633)
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• on either a high or low fat diet postprandial triglyceride levels are reduced in female mutants compared to wild-type littermates
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• an 80% increase in triglyceride levels compared to wild-type mice is seen in male mutants after eating (postprandial)
• a larger increase in triglyceride levels is seen in male mutants compared to wild-type littermates after 4 months on a low fat diet but not on a high fat diet
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 86% of mice survive the 24 week experiment compared to only 66% of Lama2dy homozygotes
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• fewer macrophages are found within muscles compared to in Lama2dy homozygotes
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• mice exhibit 25% to 20% greater forelimb strength than Lama2dy homozygotes
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• compared to Lama2dy homozygotes
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• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice
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• mice exhibit reduce deposition of IgM in muscles compared to in Lama2dy homozygotes
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• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice
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• mice exhibit increased deposition of IgG in muscles compared to in wild-type mice
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• mice exhibit reduce deposition of IgM in muscles compared to in Lama2dy homozygotes
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• mice exhibit increased deposition of IgM in muscles compared to in wild-type mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice live normally, with none developing stroke symptoms and normal BUN, platelet and hemoglobin levels, no evidence of renal pathology or thrombus formation, and normal retina and retinal blood flow
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• polyphagia is seen compared to Lepob homozygotes
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• double knock outs have decreased body weight compared to Lepob homozygotes
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• the average calorie intake/g increase in body weight is greater in double homozygotes compared to Lepob homozygotes
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• oxygen consumption is increased relative to Lepob homozygotes and about the same as wild-type mice
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• insulin levels are decreased compared to Lepob homozygotes
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• postprandial non-esterified fatty acid levels are increased compared to Lepob homozygotes and wild-type mice
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• postprandial triglyceride clearance is delayed in both males and females
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation
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• transplanted platelets exhibit a decreased half-life compared to wild-type platelets that is complement and macrophage dependent
• however, transgenic expression of Cd55 rescues platelet half-life following transplantation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
 |
• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal
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• unlike in C3tm1Hrc Cd55tm1Song Cr1ltm1Hmo homozygotes, platelet half-life is normal
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• survival of double homozygotes is normal
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• erythrocytes show slightly increased susceptibility to antibody-induced lysis by human, but not by rat, complement compared to wild-type
• antibody-sensitized erythrocytes exhibit increased C3 deposition compared to wild-type cells
• mutant erythrocytes transfused into wild-type mice are more rapidly eliminated than controls indicating increased susceptibility to spontaneous complement attack in vivo, however cells are protected from removal when transfused to C3 deficient mice
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| N |
• when mating double homozygous females to Crrytm1Hmo heterozygous males the expected number of pups of both possible genotypes are seen unlike in the reverse situation when fewer than expected Crrytm1Hmo homozygous pups are found
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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N |
• following infection with Staphylococcus aureus, bacterial counts are normal
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/09/2024 MGI 6.23 |
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