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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cxcr5tm1Lipp
targeted mutation 1, Martin Lipp
MGI:2158677
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cxcr5tm1Lipp/Cxcr5tm1Lipp involves: 129S2/SvPas * CD-1 MGI:2658681


Genotype
MGI:2658681
hm1
Allelic
Composition
Cxcr5tm1Lipp/Cxcr5tm1Lipp
Genetic
Background
involves: 129S2/SvPas * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cxcr5tm1Lipp mutation (3 available); any Cxcr5 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• homozygotes exhibit a severely impaired lymphocyte migration to the Peyer's pathces and the B cell follicles of the spleen, resulting in morphologically abnormal primary lymphoid follicles
• activated B cells fail to migrate from the T cell-rich zone into B cell follicles of the spleen
• homozygotes display a 2- to 4-fold increase in spleen or peripheral blood cells co-expressing B220 and high amounts fo IgM
• at 8 wks of age, homozygotes display defective formation of primary splenic follicles, including: the T cell zone is located centrally but not polarized in the follicle; the T cell zone is completely surrounded by a small rim of B cell-expressing IgD but not IgM (i.e. IgM+IgD+ subset is absent); a prominent marginal zone surrounds the follicle completely
• despite high numbers of germinal center founder cells, no functional germinal centers develop in mutant spleen after immunization with the T cell-dependent antigen DNP-KHL
• absence of primary follicular dendritic cells
• ~30% (26 of 76) of homozygotes exhibit 1-4 small and rudimentary structures resembling Peyer's patches
• ~16% (12 of 76) of homozygotes exhibit normally sized Peyer's patches with multiple B and T cell-rich zones instead of the large follicles present in wild-type mice
• 55% (42 of 76) of homozygotes show complete absence of Peyer's patches
• homozygotes lack inguinal lymph nodes (J:37126)
• absence of inguinal, iliac/periaortic, axillary, branchial, deep cervical, sacral/caudal, and parathymic lymph nodes

hematopoietic system
• homozygotes exhibit a severely impaired lymphocyte migration to the Peyer's pathces and the B cell follicles of the spleen, resulting in morphologically abnormal primary lymphoid follicles
• activated B cells fail to migrate from the T cell-rich zone into B cell follicles of the spleen
• homozygotes display a 2- to 4-fold increase in spleen or peripheral blood cells co-expressing B220 and high amounts fo IgM
• at 8 wks of age, homozygotes display defective formation of primary splenic follicles, including: the T cell zone is located centrally but not polarized in the follicle; the T cell zone is completely surrounded by a small rim of B cell-expressing IgD but not IgM (i.e. IgM+IgD+ subset is absent); a prominent marginal zone surrounds the follicle completely
• despite high numbers of germinal center founder cells, no functional germinal centers develop in mutant spleen after immunization with the T cell-dependent antigen DNP-KHL

cellular
• homozygotes exhibit a severely impaired lymphocyte migration to the Peyer's pathces and the B cell follicles of the spleen, resulting in morphologically abnormal primary lymphoid follicles
• activated B cells fail to migrate from the T cell-rich zone into B cell follicles of the spleen





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory