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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bmpr2tm1Kmi
targeted mutation 1, Kohei Miyazono
MGI:2158503
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bmpr2tm1Kmi/Bmpr2tm1Kmi involves: 129S4/SvJae * C57BL/6J MGI:3620990
ht2
Bmpr2tm1Kmi/Bmpr2+ involves: 129S4/SvJae MGI:3526244
ht3
Bmpr2tm1Kmi/Bmpr2+ involves: 129S4/SvJae * C57BL/6 MGI:5430760
ht4
Bmpr2tm1Kmi/Bmpr2+ involves: 129S4/SvJae * C57BL/6J MGI:5438770
cn5
Bmpr2tm1.1Enl/Bmpr2tm1Kmi
Tg(KRT14-cre)1Ipc/0
involves: 129S4/SvJae * C57BL/6 * SJL MGI:6258665
cx6
Bmpr2tm1Kmi/Bmpr2+
Btg2tm1Spo/Btg2tm1Spo
involves: 129S4/SvJae * C57BL/6 MGI:3526247
cx7
Bmpr2tm1Kmi/Bmpr2+
Ark2cGt(P9-3F)Sor/Ark2c+
Tg(Hlxb9-GFP)1Tmj/0
involves: 129S4/SvJae * C57BL/6 * CBA MGI:5516589


Genotype
MGI:3620990
hm1
Allelic
Composition
Bmpr2tm1Kmi/Bmpr2tm1Kmi
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• at E6.5-E8.5, homozygotes are recovered at the expected Mendelian frequency but appear abnormal
• no homozygotes are recovered at E9.5

embryo
• homozygotes fail to undergo normal gastrulation
• at E7.5, homozygotes lack a properly established A-P axis
• homozygotes are arrested at the egg cylinder stage before gastrulation
• at E6.5, homozygotes exhibit progressive growth retardation and are significantly smaller than wild-type embryos
• at E6.5 and E7.5, homozygotes display impaired epiblast differentiation; in contrast, expression of tissue-specific genes for visceral endoderm differentiation is relatively normal
• at E6.5, homozygotes fail to form elongated egg cylinders
• at E7.5, homozygous mutant embryos lack a mesoderm layer
• at E7.5, homozygotes lack a morphologically identifiable primitive streak
• at E6.5, homozygous mutant embryos are disorganized and lack a clear distinction between the embryonic and extraembryonic portions

growth/size/body
• at E6.5, homozygotes exhibit progressive growth retardation and are significantly smaller than wild-type embryos




Genotype
MGI:3526244
ht2
Allelic
Composition
Bmpr2tm1Kmi/Bmpr2+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• eight ribs, instead of nine, were attached to the sternum
• exhibited alleviated vertebral defects compared to homozygous Acvr2b mutants
• transformation of the 23rd vertebra to the 16th thoracic vertebra (as seen in homozygous Acvr2b mutants) was incomplete
• vertebra 29 of most mutants was transformed to the first sacral vertebra instead to the 6th lumbar vertebra (as seen in homozygous Acvr2b mutants)




Genotype
MGI:5430760
ht3
Allelic
Composition
Bmpr2tm1Kmi/Bmpr2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• heterozygotes exhibit an increase in wall thickness of muscularized pulmonary arteries
• heterozygotes exposed to hypoxia exhibit impaired muscularization of small pulmonary arteries in both the distal intra-acinar vessels and in proximal preacinar vessels, with 25% less increase in wall thickness compared to controls
• the number of alveoli (and associated capillaries called alveolar-capillary units) per millimeter squared is 40% greater in heterozygotes
• heterozygotes exposed to prolonged hypoxia exhibit impaired pulmonary vascular remodeling, with a smaller increase in pulmonary artery pressure, greater right ventricular hypertrophy, decrease in the number of alveolar-capillary units per millimeter squared, and decreased wall thickness (muscularization) of small pulmonary arteries compared to controls
• increase in mean total pulmonary vascular resistance and in incremental pulmonary resistance
• however total systemic vascular resistance is not different
• increase in mean pulmonary arterial pressure
• however, mean systemic arterial pressure is not different from controls
• heterozygotes exposed to prolonged hypoxia show a smaller increase in pulmonary artery pressure than control mice
• mutants develop mild pulmonary hypertension

respiratory system
• the number of alveoli (and associated capillaries called alveolar-capillary units) per millimeter squared is 40% greater in heterozygotes
• heterozygotes exposed to prolonged hypoxia exhibit impaired pulmonary vascular remodeling, with a smaller increase in pulmonary artery pressure, greater right ventricular hypertrophy, decrease in the number of alveolar-capillary units per millimeter squared, and decreased wall thickness (muscularization) of small pulmonary arteries compared to controls
• the number of alveoli (and associated capillaries called alveolar-capillary units) per millimeter squared is 40% greater in heterozygotes, decreasing the vessels-to-alveoli ratio




Genotype
MGI:5438770
ht4
Allelic
Composition
Bmpr2tm1Kmi/Bmpr2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit increased right ventricular systolic pressure compared to wild-type mice with the same treatment, indicating increased sensitivity to stress-induced pulmonary hypertension
• however, mutants exhibit normal right ventricular systolic pressure and do not develop pulmonary hypertension spontaneously under unstressed conditions
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction

immune system
• minor increase in adhesion of leukocytes to the vessel wall in the lungs

mortality/aging
• about 20% fewer than the expected number of heterozygous mice were detected, indicating loss in early development
• most mice that do not survive, die in utero, although some die in the immediate postnatal stage

muscle
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit enhanced pulmonary vasoconstriction

respiratory system
• mutants with adenovirus-mediated pulmonary overexpression of 5-lipoxygenase to induce inflammation in the lungs exhibit a greater number of muscularized vessels than in the lungs from wild-type mice

hematopoietic system
• minor increase in adhesion of leukocytes to the vessel wall in the lungs




Genotype
MGI:6258665
cn5
Allelic
Composition
Bmpr2tm1.1Enl/Bmpr2tm1Kmi
Tg(KRT14-cre)1Ipc/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1.1Enl mutation (1 available); any Bmpr2 mutation (45 available)
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
Tg(KRT14-cre)1Ipc mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are healthy, fertile, and overtly normal with no apparent skin defects




Genotype
MGI:3526247
cx6
Allelic
Composition
Bmpr2tm1Kmi/Bmpr2+
Btg2tm1Spo/Btg2tm1Spo
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
Btg2tm1Spo mutation (0 available); any Btg2 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• mutants exhibited similar vertebral abnormalities as single homozygous Btg2 mutants, with no differences in the severity of phenotype




Genotype
MGI:5516589
cx7
Allelic
Composition
Bmpr2tm1Kmi/Bmpr2+
Ark2cGt(P9-3F)Sor/Ark2c+
Tg(Hlxb9-GFP)1Tmj/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ark2cGt(P9-3F)Sor mutation (0 available); any Ark2c mutation (11 available)
Bmpr2tm1Kmi mutation (0 available); any Bmpr2 mutation (45 available)
Tg(Hlxb9-GFP)1Tmj mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• fewer than expected mice are born
• however, all born mice survive to adulthood

nervous system
• some mice exhibit innervation defects in the dorsal forelimb

behavior/neurological
• some mice exhibit reduced hang time from a cage lid compared with wild-type mice





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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory