Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox11tm2.2Weg mutation
(0 available);
any
Sox11 mutation
(14 available)
Sox4tm1Vlf mutation
(0 available);
any
Sox4 mutation
(20 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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embryo
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• increased cell death without a decrease in cell proliferation
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nervous system
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• increased cell death without a decrease in cell proliferation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm4Wbm mutation
(1 available);
any
Ctnnb1 mutation
(49 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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• proliferation of cells declined by E10
• 45% at E11 to 50% at E11.5
• E11 proliferation rate down 35%
• 4.8X increase in progenitor cell death and apoptosis
• higher proportion of differentiated neurons to proliferative cells
• number of neurons unchanged
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• changes similar to those seen in the spinal cord
• tissue mass of the midbrain was reduced
• progenitor domains in the midbrain and other areas of the brain reduced
• increased apoptosis
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• ventricular zone absent at E12
• reduced area occupied by progenitor cells
• ventral progenitor are absent by E11.5
• absent dorsally by E12
• Larger area occupied by differentiated neurons(as determined immunohistochemically and gene markers)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox10tm7.1(Sox10)Weg mutation
(0 available);
any
Sox10 mutation
(33 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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• at P7, numbers of Zfp276-positive oligodendrocytes in the spinal cord only reach about 7% of those in controls, as identified by Olig2 co-staining
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3.1Jbr mutation
(2 available);
any
Phox2b mutation
(25 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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• mice exhibit phenotypic defects observed in Phox2btm1Jbr homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm4Jbr mutation
(1 available);
any
Phox2b mutation
(25 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Phox2btm3.1Jbr mutation
(2 available);
any
Phox2b mutation
(25 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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N |
• despite the absence of visceral or branchial motoneurons, the main trunk of the facial nerve is present
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• visceromotor neurons are not produced
• absence of visceral or branchial motoneurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation
(1 available);
any
Bmpr1a mutation
(89 available)
Bmpr1atm2Bhr mutation
(0 available);
any
Bmpr1a mutation
(89 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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mortality/aging
integument
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• lacked external hair in mid ventrum
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• shafts usually fail to form in follicles
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• misshapen and expanded dermal papillae
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• misangled
• not as deep into the dermis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm1Bhr mutation
(1 available);
any
Bmpr1a mutation
(89 available)
Bmpr1atm2.1Bhr mutation
(1 available);
any
Bmpr1a mutation
(89 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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limbs/digits/tail
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• ectopic distal phalanges are sometimes found
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• although reduced digits is typical, polydactyly sometimes occurs
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• polysyndactyly is common
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• if hindlimbs are present then they are highly malformed
• loss of ventral structures of hindlimbs
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• in many but not all animals
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1atm2.1Bhr mutation
(1 available);
any
Bmpr1a mutation
(89 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arxtm1Gldn mutation
(0 available);
any
Arx mutation
(20 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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• whole brain is smaller than wild-type brain at E18.5
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• normal distribution of interneurons in cerebral cortex is lost in mutants, with Calb1+ interneurons restricted to subcortical and subventricular regions
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• olfactory bulbs are nearly absent at E18.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation
(0 available);
any
Ctnnb1 mutation
(49 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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• increased proliferation of cells by E10
• 110% at E11 to 300% at E11.5
• E11 proliferation rate increased 1.4X
• 6.7% increase in progenitor cell death and apoptosis
• lower proportion of differentiated neurons to proliferative cells
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• changes similar to those seen in the spinal cord
• tissue mass of the midbrain was increased
• increased proliferation in all areas of the brain
• progenitor domains of the midbrain and other areas of the brain increased
• increased apoptosis
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• enlarged ventricular zone at E10.5
• increased area occupied by neural progenitor cells
• smaller area occupied by differentiated neurons (as determined immunohistochemically and by activity of genes expressed in progenitor cells)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl11atm1Sbri mutation
(0 available);
any
Bcl11a mutation
(42 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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nervous system
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• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation
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• almost complete loss of small diameter nociceptive fibers in the dorsal horn
• reduction in the innervation of TrkA+ and aquaporin 1+ sensory neurons in the dorsal horn
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• in dorsal spinal neurons neurites are severely reduced and remaining structures often appear misshapen
• cultured neurons from the superficial dorsal horn show a decrease in the overall number, length and branching frequency of neurites
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• almost complete loss of small diameter nociceptive fibers in the dorsal horn at E16.5
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• the superficial zone is invariably compressed and the nuclei appear compacted
• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation
• in dorsal spinal neurons neurites are severely reduced and remaining structures often appear misshapen
• the density of DiI positive fibers is greatly reduced and the remaining fibers appear disorganized at E16.5
• almost complete loss of small diameter nociceptive fibers in the dorsal horn
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• the success rate for evoked currents is reduced in dorsal horn neurons
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cellular
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• expression of late differentiation markers in dorsal spinal neurons is reduced indicating a defect in terminal differentiation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhoatm1Jrel mutation
(0 available);
any
Rhoa mutation
(70 available)
Tg(Pou3f4-cre)32Cren mutation
(0 available)
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mortality/aging
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• mice die at late embryonic stages
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nervous system
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N |
• mice exhibit normal basolateral and radial fibers, and glia- and motor neuron generation
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• increased apoptosis in the spinal cord at E11.5 and E12.5
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• at E13.5, cultured neurospheres exhibit reduced self-renewal compared with wild-type cells
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• at E10.5 and E11.5, spinal cord cells exhibit early cell-cycle exit compared with wild-type cells
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• at E11.5, spinal cords lack a well-organized ventricular zone and exhibit dysplasia, likely due to neuroepithelial cells invading the lumen of the neural tube, compared with wild-type mice
• rossette-like structures are present in the ventricular zone of the spinal cord unlike in wild-type mice
• at E14.5, the ventricular zone and neural tube lumen are missing unlike in wild-type mice
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embryo
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• at E11.5, spinal cords lack a well-organized ventricular zone and exhibit dysplasia, likely due to neuroepithelial cells invading the lumen of the neural tube, compared with wild-type mice
• rossette-like structures are present in the ventricular zone of the spinal cord unlike in wild-type mice
• at E14.5, the ventricular zone and neural tube lumen are missing unlike in wild-type mice
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cellular
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• increased apoptosis in the spinal cord at E11.5 and E12.5
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• at E13.5, cultured neurospheres exhibit reduced self-renewal compared with wild-type cells
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• at E10.5 and E11.5, spinal cord cells exhibit early cell-cycle exit compared with wild-type cells
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Analysis Tools