Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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cardiovascular system
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• isolated cardiac myocytes exhibit a significant increase in fractional cell shortening and higher dL/dT values
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type
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• induced by atrial burst pacing that is not prevented by 1,4-benzothiazepine (Rycal S107)-treatment
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• under baseline conditions, left ventricular myocytes exhibit an enhanced calcium transient amplitude and faster calcium transient decays
• left ventricular myocytes do not show an increase in the intracellular calcium transient amplitudes or accelerated calcium transient decays when treated with isoproterenol as is seen in wild-type
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muscle
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• isolated cardiac myocytes exhibit a significant increase in fractional cell shortening and higher dL/dT values
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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cardiovascular system
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• no increased contractility in response to beta-adrenergic agonists
(J:39745)
• large force developed at low frequencies of stimulation but more like controls at higher frequencies
(J:59967)
• no acceleration of time to peak tension with increasing frequency of stimulation, similar observation for relaxation time
(J:59967)
• declining rate of force development with increased frequency of stimulation
(J:59967)
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• diastolic and end diastolic pressures were decreased
• rates of pressure development were increased
• systolic intraventricular pressure increased
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muscle
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• no increased contractility in response to beta-adrenergic agonists
(J:39745)
• large force developed at low frequencies of stimulation but more like controls at higher frequencies
(J:59967)
• no acceleration of time to peak tension with increasing frequency of stimulation, similar observation for relaxation time
(J:59967)
• declining rate of force development with increased frequency of stimulation
(J:59967)
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Allelic
Composition |
Plntm1Egk/Plntm1Egk
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Genetic
Background |
involves: 129S2/SvPas * CF-1 * FVB/N |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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cardiovascular system
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• the heart weight to body weight ratio is 10% greater compared to controls
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growth/size/body
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• the heart weight to body weight ratio is 10% greater compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp2a2tm1Fwuy mutation
(0 available);
any
Atp2a2 mutation
(76 available)
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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growth/size/body
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• in double homozygous mice, heart weight/body weight ratios and heart weight/tibial length ratios are increased compared to wild-type
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• in double homozygous mice at 12-16 weeks, concentric hypertrophy was aggravated compared to single Atp2a2tm1Fwuy homozygous mice
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mortality/aging
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• the life span of mutant mice was severely shortened at 496 average age in days
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cardiovascular system
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• the cardiomyocyte dimensions in double homozygous mice were increased to a much larger extent than in single Atp2a2tm1Fwuy homozygous mice
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• the hearts from double homozygous mice were more hypertrophic and balloon-shaped than the heart from single Atp2a2tm1Fwuy homozygous mice
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• in double homozygous mice, heart weight/body weight ratios and heart weight/tibial length ratios are increased compared to wild-type
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• in double homozygous mice at 12-16 weeks, concentric hypertrophy was aggravated compared to single Atp2a2tm1Fwuy homozygous mice
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• in double homozygous mice at 12-16 weeks, echocardiographic measurements showed thicker posterior wall than single Atp2a2tm1Fwuy homozygous mice
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• cardiac sections showed a larger LV mass-measured as cross-sectional area
• LV wall thickening was not the result of increased interstitial fibrosis
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• beta-adrenergic stimulation in double homozygous mice failed to increase the cardiac output
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• maximal and minimal LV volume and stroke volume appeared lower in double homozygous mice at 12-16 weeks
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• impaired LV relaxation assessed by dP/dt min in double homozygous mice at 12-16 weeks compared to wild-type mice
• contractility assessed by dP/dt max were normal
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• in double homozygous mice at 12-16 weeks compared to wild-type
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• two out of 16 double homozygous mice died after completing running performance test on a rodent treadmill displaying clinical signs of congestive heart failure
• beta-adrenergic stimulation impaired LV contractility and relaxation and caused acute heart failure during the procedure
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behavior/neurological
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• the spontaneous activity was severely reduced in double homozygous mice at 12-16 weeks of age compared to wild-type and single Atp2a2tm1Fwuy homozygous mice
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homeostasis/metabolism
muscle
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• the cardiomyocyte dimensions in double homozygous mice were increased to a much larger extent than in single Atp2a2tm1Fwuy homozygous mice
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• impaired LV relaxation assessed by dP/dt min in double homozygous mice at 12-16 weeks compared to wild-type mice
• contractility assessed by dP/dt max were normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation
(0 available);
any
Hprt1 mutation
(1273 available)
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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cardiovascular system
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• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
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• under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice
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muscle
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• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1Dhm mutation
(0 available);
any
Hprt1 mutation
(1273 available)
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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cardiovascular system
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• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
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• under baseline conditions, left ventricular myocytes exhibit faster calcium transient decays than wild-type, however they are slower than in single homozygous Pln mutant mice
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muscle
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• isolated cardiac myocytes exhibit enhanced fractional cell shortening and higher dL/dT values compared to wild-type, however this shortening and dL/dT values are less than that seen in the single homozygous Pln mutant mouse
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• isolated cardiac myocytes exhibit higher relaxation rates (-dL/dt) than wild-type but lower than that seen in single homozygous Pln mutant mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Zdhhc16tm1Goff mutation
(0 available);
any
Zdhhc16 mutation
(22 available)
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mortality/aging
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• fail to survive to P2; however, almost all survive to birth
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cardiovascular system
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N |
• double mutation rescues the histopathological defects (cardiomyocyte disarray, nuclear malformations, decreased sarcomere numbers) and bradycardia seen in Zdhhc16 null mice
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vision/eye
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Tg(Myh6-Pln)11Egk mutation
(1 available)
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cardiovascular system
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• ventricular myocytes exhibit increases in shortening fraction, rates of shortening and de-lengthening following maximal stimulation with the beta adrenergic agonist, isoproterenol, however, these increases are lower than increases experienced by controls
• basal cardiac function is similar to control
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• maximal isoproterenol stimulation has little effect on the Ca2+ amplitude peak and no effect on the decline of Ca2+ transient in myocytes
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muscle
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• ventricular myocytes exhibit increases in shortening fraction, rates of shortening and de-lengthening following maximal stimulation with the beta adrenergic agonist, isoproterenol, however, these increases are lower than increases experienced by controls
• basal cardiac function is similar to control
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Tg(Myh6-Pln)22Egk mutation
(1 available)
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cardiovascular system
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N |
• ventricular myocytes exhibit increases in shortening fraction, rates of shortening and de-lengthening following maximal stimulation with the beta adrenergic agonist, isoproterenol, however, these increases are similar to those observed in mice expressing Plntm1Egk Tg(Myh6-Pln)1Egk (wild type phospholambin)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Tg(Myh6-Pln)1Egk mutation
(1 available)
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cardiovascular system
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N |
• mutant mice appear phenotypically normal; transgene expression rescues cardiac function
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Tnnt2tm2.1Feah mutation
(0 available);
any
Tnnt2 mutation
(52 available)
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cardiovascular system
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• mice exhibit left ventricular dilatation
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• dilated cardiomyopathy is similar to that seen in single Tnnt2 heterozygotes
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• mice exhibit decreased fractional shortening
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muscle
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• dilated cardiomyopathy is similar to that seen in single Tnnt2 heterozygotes
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• mice exhibit decreased fractional shortening
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Tg(Myh6*)140Lnwd mutation
(0 available)
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cardiovascular system
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• the heart weight to body weight ratio is 30% greater compared to controls
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growth/size/body
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• the heart weight to body weight ratio is 30% greater compared to controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csrp3tm1Crni mutation
(0 available);
any
Csrp3 mutation
(15 available)
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
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cardiovascular system
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• indicated by a slight increase in the heart weight/body weight ratio
• heart structure is otherwise normalized compared to conditions in mice homozygous for with Csrp3Tm1Crni only
• more normal heart size
• normalized myofibrillar organization
• no fibrosis
• normal cardiac chamber dimensions as indicated by echocardiography
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• increased contractile properties similar to those of mice homozygous for Plntm1Egk only
• normalized left ventricular relaxation and diastolic function
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• slightly decreased relative to wild-type
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muscle
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• increased contractile properties similar to those of mice homozygous for Plntm1Egk only
• normalized left ventricular relaxation and diastolic function
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growth/size/body
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• indicated by a slight increase in the heart weight/body weight ratio
• heart structure is otherwise normalized compared to conditions in mice homozygous for with Csrp3Tm1Crni only
• more normal heart size
• normalized myofibrillar organization
• no fibrosis
• normal cardiac chamber dimensions as indicated by echocardiography
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plntm1Egk mutation
(7 available);
any
Pln mutation
(16 available)
Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mutation
(1 available)
Tg(Myh6-tTA)55Rbns mutation
(2 available)
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cardiovascular system
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• improved compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• more severe than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• as in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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• faster mechanical relaxation of myocyte contraction compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
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• faster Ca2+ transient decay time compared with Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol
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growth/size/body
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• more severe than in Tg(Myh6/tetO-Tnnc1*I61Q)1Jmol mice
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Analysis Tools