Phenotypes associated with this allele
mortality/aging
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• 67% of mice die early with a median life span of 16 months
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cardiovascular system
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• irregular heart rhythm and sudden drops in heart rate
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• increase in heart rate variability during both the light and dark cycles
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• heart rate during the dark cycle is decreased but is not different during the light cycle
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• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia
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• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia
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• mice are highly susceptible to inducible arrhythmias
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homeostasis/metabolism
behavior/neurological
N |
• mice show no differences in activity during the light or dark cycle
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respiratory system
N |
• mice do not exhibit increased basal apneas or abnormal hypoxic response
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation
(0 available);
any
Mapt mutation
(428 available)
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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mortality/aging
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• most mice die between 8 weeks and 24 weeks of age
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behavior/neurological
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation
(0 available);
any
Mapt mutation
(428 available)
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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mortality/aging
|
• most mice die between 8 weeks and 24 weeks of age
|
behavior/neurological
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Camk2a-cre)93Kln mutation
(1 available)
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behavior/neurological
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• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait
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• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity
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growth/size/body
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• 7 of 11 become overweight and obese at 10 weeks of age or older
• mutants appear healthy for up to 3 months when they begin to gain weight
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nervous system
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• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age
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• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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mortality/aging
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• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death
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behavior/neurological
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• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age
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• exhibit body trembling at 5 weeks of age
• at late stages of disease, mutants tremble when handled
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• seen at late stages of disease
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nervous system
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• neurons in the CA2 region are 15-25% smaller than in controls at 8 weeks of age
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• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed
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growth/size/body
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• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease
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• 6 of 18 become overweight and obese at 40-60 days of age
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respiratory system
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• occasionally show heavy breathing at 5 weeks of age
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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behavior/neurological
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• females appear normal for the first 4 months but show ataxic gait at later ages
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• females appear normal for the first 4 months but show hypoactivity at later ages
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growth/size/body
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• females appear normal for the first 4 months but gain weight at later ages
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Myh6-cre)2182Mds mutation
(3 available)
|
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behavior/neurological
N |
• mice show no differences in activity in either the light or dark phases
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cardiovascular system
N |
• mice do not exhibit an increase in sinus pauses, premature ventricular contractions, atrioventricular block, or nonsustained ventricular tachycardia, and do not show QT prolongation or increased susceptibility to induced arrhythmias
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
Tg(Camk2a-Setdb1)1Akba mutation
(0 available)
Tg(Nes-cre)1Atp mutation
(0 available)
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mortality/aging
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• mice die between 8 and 40 weeks of age
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behavior/neurological
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• worse than in Mecp2tm1Jae/Y mice
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growth/size/body
Allelic Composition |
Mecp2tm1Jae/Y
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation
(2 available);
any
Mecp2 mutation
(38 available)
|
|
|
behavior/neurological
growth/size/body
mortality/aging
|
• mice die between 8 and 40 weeks of age
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