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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mecp2tm1Jae
targeted mutation 1, Rudolf Jaenisch
MGI:2158353
Summary 9 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Mecp2tm1Jae/Y
Chattm2(cre)Lowl/Chat+
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J MGI:6098756
cn2
Mapttm1(Setdb1)Akba/Mapt+
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5299159
cn3
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:5299160
cn4
Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J MGI:3624685
cn5
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:3624680
cn6
Mecp2tm1Jae/Mecp2+
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N MGI:3624684
cn7
Mecp2tm1Jae/Y
Tg(Myh6-cre)2182Mds/0
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * FVB/N MGI:6098758
cn8
Mecp2tm1Jae/Y
Tg(Camk2a-Setdb1)1Akba/0
Tg(Nes-cre)1Atp/0
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL MGI:5299161
ot9
Mecp2tm1Jae/Y involves: 129S4/SvJae * C57BL/6 MGI:5299162


Genotype
MGI:6098756
cn1
Allelic
Composition
Mecp2tm1Jae/Y
Chattm2(cre)Lowl/Chat+
Genetic
Background
involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chattm2(cre)Lowl mutation (3 available); any Chat mutation (35 available)
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 67% of mice die early with a median life span of 16 months

cardiovascular system
• irregular heart rhythm and sudden drops in heart rate
• increase in heart rate variability during both the light and dark cycles
• heart rate during the dark cycle is decreased but is not different during the light cycle
• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia
• mice show an increased rate of spontaneous ventricular arrhythmias including premature ventricular contractions and nonsustained ventricular tachycardia
• mice are highly susceptible to inducible arrhythmias

homeostasis/metabolism
• mice are highly susceptible to inducible arrhythmias
• mice exhibit decreased temperature during the dark cycle but not the light cycle

behavior/neurological
N
• mice show no differences in activity during the light or dark cycle

respiratory system
N
• mice do not exhibit increased basal apneas or abnormal hypoxic response

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:241788




Genotype
MGI:5299159
cn2
Allelic
Composition
Mapttm1(Setdb1)Akba/Mapt+
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation (0 available); any Mapt mutation (408 available)
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Nes-cre)1Atp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between 8 weeks and 24 weeks of age

behavior/neurological




Genotype
MGI:5299160
cn3
Allelic
Composition
Mapttm1(Setdb1)Akba/Mapttm1(Setdb1)Akba
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mapttm1(Setdb1)Akba mutation (0 available); any Mapt mutation (408 available)
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Nes-cre)1Atp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die between 8 weeks and 24 weeks of age

behavior/neurological




Genotype
MGI:3624685
cn4
Allelic
Composition
Mecp2tm1Jae/Y
Tg(Camk2a-cre)93Kln/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Camk2a-cre)93Kln mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mutants appear healthy for up to 3 months when they begin to exhibit an ataxic gait
• mutants appear healthy for up to 3 months when they begin to show reduced nocturnal activity

growth/size/body
• 7 of 11 become overweight and obese at 10 weeks of age or older
• mutants appear healthy for up to 3 months when they begin to gain weight

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 7.5 months of age
• exhibit smaller neuronal bodies in the cortex and hippocampus but not in the cerebellum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:67909




Genotype
MGI:3624680
cn5
Allelic
Composition
Mecp2tm1Jae/Y
Tg(Nes-cre)1Atp/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Nes-cre)1Atp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most die at about 10 weeks of age without obvious correlation between physical deterioration and time of death

behavior/neurological
• appear healthy for the first few weeks of age but develop abnormal behavior, such as nervousness, at 5 weeks of age
• exhibit body trembling at 5 weeks of age
• at late stages of disease, mutants tremble when handled
• seen at late stages of disease

nervous system
• neurons in the CA2 region are 15-25% smaller than in controls at 8 weeks of age
• cell bodies and nuclei or neurons in sections of hippocampus, cerebral cortex, and cerebellum are smaller in size and more densely packed

growth/size/body
• most exhibit signs of physical deterioration by 8 weeks of age and often begin to lose weight at late stages of disease
• 6 of 18 become overweight and obese at 40-60 days of age

respiratory system
• occasionally show heavy breathing at 5 weeks of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Rett syndrome DOID:1206 OMIM:312750
OMIM:613454
J:67909




Genotype
MGI:3624684
cn6
Allelic
Composition
Mecp2tm1Jae/Mecp2+
Tg(Nes-cre)1Atp/0
Genetic
Background
involves: 129S4/SvJae * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Nes-cre)1Atp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• females appear normal for the first 4 months but show ataxic gait at later ages
• females appear normal for the first 4 months but show hypoactivity at later ages

growth/size/body
• females appear normal for the first 4 months but gain weight at later ages




Genotype
MGI:6098758
cn7
Allelic
Composition
Mecp2tm1Jae/Y
Tg(Myh6-cre)2182Mds/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Myh6-cre)2182Mds mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice show no differences in activity in either the light or dark phases

cardiovascular system
N
• mice do not exhibit an increase in sinus pauses, premature ventricular contractions, atrioventricular block, or nonsustained ventricular tachycardia, and do not show QT prolongation or increased susceptibility to induced arrhythmias

homeostasis/metabolism
N
• mice show no changes in temperature in either the light or dark phases




Genotype
MGI:5299161
cn8
Allelic
Composition
Mecp2tm1Jae/Y
Tg(Camk2a-Setdb1)1Akba/0
Tg(Nes-cre)1Atp/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
Tg(Camk2a-Setdb1)1Akba mutation (0 available)
Tg(Nes-cre)1Atp mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between 8 and 40 weeks of age

behavior/neurological
• worse than in Mecp2tm1Jae/Y mice

growth/size/body




Genotype
MGI:5299162
ot9
Allelic
Composition
Mecp2tm1Jae/Y
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mecp2tm1Jae mutation (2 available); any Mecp2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological

growth/size/body

mortality/aging
• mice die between 8 and 40 weeks of age





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last database update
01/09/2018
MGI 6.11
The Jackson Laboratory