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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccr2tm1Mae
targeted mutation 1, Nobuyo Maeda
MGI:2158345
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccr2tm1Mae/Ccr2tm1Mae B6.129P2-Ccr2tm1Mae MGI:3841005
hm2
Ccr2tm1Mae/Ccr2tm1Mae involves: 129P2/OlaHsd MGI:4355951
hm3
Ccr2tm1Mae/Ccr2tm1Mae involves: 129P2/OlaHsd * BALB/c MGI:4834178
hm4
Ccr2tm1Mae/Ccr2tm1Mae involves: 129P2/OlaHsd * C57BL/6J MGI:3654650
cx5
Ccl2tm1Rol/Ccl2tm1Rol
Ccr2tm1Mae/Ccr2tm1Mae
B6.129-Ccr2tm1Mae Ccl2tm1Rol MGI:4418654
cx6
Ay/a
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Mae/Ccr2tm1Mae
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl MGI:5297861


Genotype
MGI:3841005
hm1
Allelic
Composition
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
B6.129P2-Ccr2tm1Mae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Mae mutation (3 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
respiratory system
• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice

vision/eye
• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice
• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice
• at 16 months, mice exhibit progressive outer retinal degeneration and confluent areas of visible atrophy unlike in wild-type mice
• at 18 months, mice exhibit geographic atrophy unlike in wild-type mice
• after 9 months of age, mice exhibit subretinal deposits similar to drusen that increase with age unlike in wild-type mice
• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice
• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice
• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice
• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice
• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice
• the Bruch membrane is thickened compared to in wild-type mice after 9 months of age
• at 20 months, the outer Bruch membrane is breached by choriocapillary processes unlike in wild-type mice

behavior/neurological
• mice exhibit decreased preference for ethanol water compared with wild-type mice
• female mice exhibit a lesser ethanol preference compared with Ccl2tm1Rol Ccr2tm1Mae double homozygotes
• mice develop a stronger ethanol-induced conditioned taste aversion compared with similarly treated wild-type mice
• mice exhibit increased drinking of a quinine solution compared with wild-type mice
• mice exhibit increased drinking of an ethanol solution compared with wild-type mice and Ccl2tm1Rol Ccr2tm1Mae double homozygotes

immune system
• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice
• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice
• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice
• mice infected with a recombinant mouse-adapted SARS-CoV, rMA15, develop more severe denuding bronchiolitis than similarly infected wild-type mice
• mice show increased susceptibility to infection with a recombinant mouse-adapted SARS-CoV, rMA15 , developing more severe and prolonged disease compared to wild-type mice, showing more prominent airway epithelial cell apoptosis, severe denuding bronchiolitis and perivenular/periarterial cuffing

cardiovascular system
• at 16 months, mice exhibit dilation and attenuation of the choriocapillaris unlike wild-type mice
• at 15 to 19 months, mice exhibit intrachoroidal neovascularization with angiographic leakage unlike wild-type mice
• after 18 months, 3 of 13 mice exhibit choroidal neovascularization with angiographic leakage unlike in wild-type mice
• between 18 and 27 months, neovasculatization breaches the Bruch membrane and causes retinal pigmented epithelium and photoreceptor disruptions unlike in wild-type mice

nervous system

pigmentation
• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice
• at 16 months, mice exhibit attenuation of the retinal pigmented epithelium unlike in wild-type mice
• after 9 months of age, lipofuscin granules are observed in the swollen and vacuolated retinal pigmented epithelial cells unlike in wild-type mice

hematopoietic system
• age-dependent accumulation of macrophages in the choroids is less than in wild-type mice
• at 16 months, IgG is present in the retinal pigmented epithelium or choroids unlike in wild-type mice
• IgG light chain deposition in the retinal pigmented epithelium accumulates with age unlike in wild-type mice




Genotype
MGI:4355951
hm2
Allelic
Composition
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Mae mutation (3 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice
• very few macrophages are recruited in response to induced peritonitis (J:151874)
• recruitment of macrophages in mice homozygous for Ccl2tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)
• there is over a 2-fold increase in Ccl2 and Ccl7 secretion by activated macrophages compared to controls

cellular
• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice
• very few macrophages are recruited in response to induced peritonitis (J:151874)
• recruitment of macrophages in mice homozygous for Ccl2tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)

hematopoietic system
• LPS-induced monocyte emigration is decreased compared to in similarly treated wild-type mice
• very few macrophages are recruited in response to induced peritonitis (J:151874)
• recruitment of macrophages in mice homozygous for Ccl2tm1Lex is impaired recruitment compared with recruitment of wild-type cells (J:191510)




Genotype
MGI:4834178
hm3
Allelic
Composition
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
involves: 129P2/OlaHsd * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Mae mutation (3 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• following kidney ischemia and reperfusion
• following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice
• following kidney ischemia and reperfusion

homeostasis/metabolism
• following kidney ischemia and reperfusion, plasma creatinine levels fail to increase as in similarly treated wild-type mice
• following kidney ischemia and reperfusion, mice fail to exhibit an increase in plasma creatinine levels and exhibit reduced renal tubular cell necrosis and neutrophil and macrophage infiltration compared with similarly treated wild-type mice

renal/urinary system
• following kidney ischemia and reperfusion, mice fail to exhibit an increase in plasma creatinine levels and exhibit reduced renal tubular cell necrosis and neutrophil and macrophage infiltration compared with similarly treated wild-type mice

hematopoietic system
• following kidney ischemia and reperfusion
• following kidney ischemia and reperfusion, mice exhibit reduced monocyte egress from the blood into the inflamed kidney compared with similarly treated wild-type mice
• following kidney ischemia and reperfusion

cellular
• following kidney ischemia and reperfusion




Genotype
MGI:3654650
hm4
Allelic
Composition
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Mae mutation (3 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• mice lose ~15% body weight by day 7 of treatment, comparable to wild-type

immune system
• mice develop DSS-mediated colitis at a delayed and lower severity compared to wild-type treated mice after 7 days of treatment
• mice display an increase in B cell number in the lamina propria from 27 to 43% compared to wild-type and Ccr5-deficient mice which show a transient decrease in number at day 3 and then rebound to original values by day 7 of treatment
• a decrease in number is observed at day 3 of DSS treatment
• an increase in number is observed at day 3
• mice expression one fifth the wild-type level of Ifng in the intestinal mucosa after day 3 and 7, while Il-4 is increased 3-fold and a 9-fold increase in Il-10 over wild-type and 4-fold greater than Ccr5-deficient mice after DSS-treatment
• mice show significantly fewer intraabdominal adhesions than wild-type; the colons are less erythamatous and show less ulceration; average percentage of ulcerated tissue is less than wild-type at day 3 of treatment

digestive/alimentary system
• by day 7 of a course of dextran sodium sulfate (DSS) in drinking water, null mice develop stool diarrhea and hemoccult-positive, often bloody stool similar to wild-type; development of diarrhea and bloody stools is delayed compared to wild-type with diminished hemoccult scores on day 4 and diminished diarrhea on days 1, 3, and 4
• mice develop DSS-mediated colitis at a delayed and lower severity compared to wild-type treated mice after 7 days of treatment

hematopoietic system
• mice display an increase in B cell number in the lamina propria from 27 to 43% compared to wild-type and Ccr5-deficient mice which show a transient decrease in number at day 3 and then rebound to original values by day 7 of treatment
• a decrease in number is observed at day 3 of DSS treatment
• an increase in number is observed at day 3




Genotype
MGI:4418654
cx5
Allelic
Composition
Ccl2tm1Rol/Ccl2tm1Rol
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
B6.129-Ccr2tm1Mae Ccl2tm1Rol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccl2tm1Rol mutation (2 available); any Ccl2 mutation (19 available)
Ccr2tm1Mae mutation (3 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• compared to in Ccl2tm1Rol homozygotes
• compared to in Ccr2tm1Mae homozygotes
• compared to in Ccl2tm1Rol or Ccr2tm1Mae homozygotes




Genotype
MGI:5297861
cx6
Allelic
Composition
Ay/a
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Mae/Ccr2tm1Mae
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * KK/TaJcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
a mutation (229 available); any a mutation (460 available)
Apoetm1Unc mutation (32 available); any Apoe mutation (134 available)
Ay mutation (12 available); any a mutation (460 available)
Ccr2tm1Mae mutation (3 available); any Ccr2 mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
N
• mutants are protected against the metabolic syndrome, atherosclerosis, and diabetic nephropathy that develops in Ay/a Apoetm1Unc double mutants





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last database update
10/05/2021
MGI 6.17
The Jackson Laboratory