About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Igh-Jtm1Dhu
targeted mutation 1, Dennis Huszar
MGI:2158307
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Igh-Jtm1Dhu/Ightm3Tim involves: 129 * C57BL/6 MGI:3610405
cx2
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Wdr1rede/Wdr1rede
involves: 129S7/SvEvBrd * BALB/c * C57BL/6 MGI:3785509
cx3
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Il2tm1Hor/Il2tm1Hor
involves: 129/Sv * C57BL/6 MGI:3759413
cx4
Igh-Jtm1Dhu/Igh-J+
Il2tm1Hor/Il2tm1Hor
involves: 129/Sv * C57BL/6 MGI:3759414
cx5
Igh-Jtm1Dhu/Ightm2Tim involves: 129X1/SvJ * C57BL/6 MGI:3033132
cx6
Igh-Jtm1Dhu/Ightm1Tim involves: 129X1/SvJ * C57BL/6 MGI:3033131
cx7
Igh-Jtm1Dhu/Igh-Jtm1(VDJ-17.2.25)Wabl
Igktm1Dhu/Igktm1Dhu
Not Specified MGI:3045805


Genotype
MGI:3610405
cx1
Allelic
Composition
Igh-Jtm1Dhu/Ightm3Tim
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Ightm3Tim mutation (0 available); any Igh mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
• B cell in mutants are reduced in the spleen, bone marrow and LNs

immune system
• preferentially promoted development to marginal zone B cell
• inefficiently drives bone marrow B lymphopoiesis and follicular B cell development
• B cell in mutants are reduced in the spleen, bone marrow and LNs




Genotype
MGI:3785509
cx2
Allelic
Composition
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Wdr1rede/Wdr1rede
Genetic
Background
involves: 129S7/SvEvBrd * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Wdr1rede mutation (0 available); any Wdr1 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• the phenotype is similar to mice that are homozygote only for the Wdr1rede allele indicating that the inflammatory lesions are not the result of B-cells activity

hematopoietic system
• three week old mice have about 5-fold less platelets per liter of blood compared to wild-type littermates




Genotype
MGI:3759413
cx3
Allelic
Composition
Igh-Jtm1Dhu/Igh-Jtm1Dhu
Il2tm1Hor/Il2tm1Hor
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Il2tm1Hor mutation (5 available); any Il2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• loss of mucin is observed in goblet cells

immune system
• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
• are increased 3-10 fold in size as compared to control littermates

digestive/alimentary system
• is rarely observed
• crypt hyperplasia and unusual branching is observed
• loss of mucin is observed in goblet cells
• occasional occurrence among mice whom live past 9 weeks of age
• occurs in mice 24 weeks of age
• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

cardiovascular system
• is rarely observed

growth/size/body
• weight loss resulting from intestinal inflammation is observed by 24 weeks

hematopoietic system
• : hemocrit levels are near normal (36% mean), suggesting B cells contribute to the anemia observed in mice lacking IL2 expression

behavior/neurological
• occurs in mice 24 weeks of age




Genotype
MGI:3759414
cx4
Allelic
Composition
Igh-Jtm1Dhu/Igh-J+
Il2tm1Hor/Il2tm1Hor
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Il2tm1Hor mutation (5 available); any Il2 mutation (32 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• loss of mucin is observed in goblet cells

immune system
• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall
• are increased 3-10 fold in size as compared to control littermates

digestive/alimentary system
• is rarely observed
• crypt hyperplasia and unusual branching is observed
• loss of mucin is observed in goblet cells
• occasional occurrence among mice whom live past 9 weeks of age
• occurs in mice 24 weeks of age
• occurs in all mice that survive past 9 weeks of age, with thickening of large intestinal wall

cardiovascular system
• is rarely observed

growth/size/body
• weight loss resulting from intestinal inflammation is observed by 24 weeks

hematopoietic system
• occurs in mice 24 weeks of age

behavior/neurological
• occurs in mice 24 weeks of age




Genotype
MGI:3033132
cx5
Allelic
Composition
Igh-Jtm1Dhu/Ightm2Tim
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Ightm2Tim mutation (0 available); any Igh mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cell surface IgM levels are somewhat lower in B220+ and E4+ cells
• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced

immune system
• cell surface IgM levels are somewhat lower in B220+ and E4+ cells
• two cell populations, one in which surface IgD levels are normal, another in which they are substantially reduced
• cell surface IgD levels as in the spleen




Genotype
MGI:3033131
cx6
Allelic
Composition
Igh-Jtm1Dhu/Ightm1Tim
Genetic
Background
involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Ightm1Tim mutation (0 available); any Igh mutation (44 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
• B cell area decreased in size

immune system
• cell surface IgM levels are generally lower and particularly lower in E4+ cells
• cell surface IgD levels are normal except in E4+ cells where it is dramatically reduced
• lambda-L chain levels were elevated 3X generally but were undetectable in E4+ B cells
• B cell development was normal in bone marrow
• splenic B cells with a follicular phenotype and are E4+
• B cells do not express endogenous mu-chain
• B cell area decreased in size




Genotype
MGI:3045805
cx7
Allelic
Composition
Igh-Jtm1Dhu/Igh-Jtm1(VDJ-17.2.25)Wabl
Igktm1Dhu/Igktm1Dhu
Genetic
Background
Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh-Jtm1Dhu mutation (1 available); any Igh-J mutation (14 available)
Igh-Jtm1(VDJ-17.2.25)Wabl mutation (0 available); any Igh-J mutation (14 available)
Igktm1Dhu mutation (1 available); any Igk mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2
• 80% of bone marrow B cells have an immature phenotype
• rapid turnover

immune system
• precursor B cells and B lymphocytes are reduced by 1/3 to 1/2
• 80% of bone marrow B cells have an immature phenotype
• rapid turnover





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/23/2022
MGI 6.20
The Jackson Laboratory