All Phenotypes Bcl2l1<tm1Dlo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl2l1^tm1Dlo
targeted mutation 1, Dennis Y Loh
MGI:2158303

Summary

9 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo	Not Specified	MGI:2176628
ht2	Bcl2l1^tm1Dlo/Bcl2l1⁺	B6.Cg-Bcl2l1^tm1Dlo	MGI:3847902
ht3	Bcl2l1^tm1Dlo/Bcl2l1^Plt20	involves: BALB/c * C57BL/6	MGI:3847905
cn4	Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu/0	B6.Cg-Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu	MGI:4840319
cx5	Bak1^tm1Thsn/Bak1^tm1Thsn Bcl2l1^tm1Dlo/Bcl2l1⁺	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn	MGI:3847907
cx6	Bak1^tm1Thsn/Bak1⁺ Bcl2l1^tm1Dlo/Bcl2l1⁺	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn	MGI:3847904
cx7	Bax^tm1Dlo/Bax^tm1Dlo Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo	involves: 129P2/OlaHsd	MGI:3609656
cx8	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/?	involves: 129S1/Sv * C57BL/6	MGI:3609571
cx9	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/Casp9^tm1Flv	involves: 129S1/Sv * C57BL/6	MGI:3609506

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:39573 )

• E12 dorsal root ganglia, brainstem and spinal cord have many more TUNEL positive cells than in wildtype mice

• E12 primary telencephalic cultures show increased apoptosis at 48 hours relative to wildtype or heterozyous cultures

cellular

increased apoptosis ( J:39573 )

increased neuron apoptosis ( J:39573 )

• E12 dorsal root ganglia, brainstem and spinal cord have many more TUNEL positive cells than in wildtype mice

• E12 primary telencephalic cultures show increased apoptosis at 48 hours relative to wildtype or heterozyous cultures

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1⁺
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytopenia ( J:149205 )

• platelet counts are significantly lower than controls (860x10³/microliter vs 1100x10³/microliter)

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

homeostasis/metabolism

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly reduced compared to controls (57 hours to 30 hours)

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^Plt20
Genetic Background	involves: BALB/c * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^Plt20 mutation (1 available); any Bcl2l1 mutation (104 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytopenia ( J:149205 )

• platelet counts are 25% of normal

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu/0
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo/Bcl2l1^tm1.1Mam Tg(Aicda-cre)9Mbu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1.1Mam mutation (0 available); any Bcl2l1 mutation (104 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
Tg(Aicda-cre)9Mbu mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:166069 )

N	• affinity maturation among NP-reactive B cells and germinal cell formation are normal

decreased IgG1 level ( J:166069 )

• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice

hematopoietic system

decreased IgG1 level ( J:166069 )

• following immunization with NP-KLH, the frequency of NP-specific IgG1 in the bone marrow compared to in similarly treated wild-type mice

Allelic Composition	Bak1^tm1Thsn/Bak1^tm1Thsn Bcl2l1^tm1Dlo/Bcl2l1⁺
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bak1^tm1Thsn mutation (2 available); any Bak1 mutation (23 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

thrombocytosis ( J:149205 )

• platelet cell numbers are about 50% higher than controls

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly increased by about 50% compared to controls

homeostasis/metabolism

abnormal platelet physiology ( J:149205 )

• platelet half-life is significantly increased by about 50% compared to controls

Allelic Composition	Bak1^tm1Thsn/Bak1⁺ Bcl2l1^tm1Dlo/Bcl2l1⁺
Genetic Background	B6.Cg-Bcl2l1^tm1Dlo Bak1^tm1Thsn

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet morphology ( J:149205 )

• the low platelet numbers of Bcl2l1^tm1Dlo heterozygotes do not occur in these mice

Allelic Composition	Bax^tm1Dlo/Bax^tm1Dlo Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bax^tm1Dlo mutation (0 available); any Bax mutation (24 available)
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:39573 )

• double heterozygous intercrosses yield no double homozygous liveborn

nervous system

decreased neuron apoptosis ( J:39573 )

• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1^tm1Dlo homozygotes with one or two copies of wildtype Bax

cellular

decreased neuron apoptosis ( J:39573 )

• E12 brainstem and ventral spinal cord and E12 primary telencephalic cultures have fewer TUNEL positive cells than Bcl2l1^tm1Dlo homozygotes with one or two copies of wildtype Bax

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/?
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l1^tm1Dlo mutation (0 available); any Bcl2l1 mutation (104 available)
Casp9^tm1Flv mutation (0 available); any Casp9 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

increased neuron apoptosis ( J:66953 )

• E12.5 brainstem and dorsal root ganglia, show increased numbers of apoptotic cells, and E12.5 primary telencephalic cultures show increased caspase 3 activation and cell death

cellular

increased apoptosis ( J:66953 )

• E12.5 liver show increased apoptotic cells

increased neuron apoptosis ( J:66953 )

• E12.5 brainstem and dorsal root ganglia, show increased numbers of apoptotic cells, and E12.5 primary telencephalic cultures show increased caspase 3 activation and cell death

Allelic Composition	Bcl2l1^tm1Dlo/Bcl2l1^tm1Dlo Casp9^tm1Flv/Casp9^tm1Flv
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

decreased apoptosis ( J:66953 )

• at E12.5 brainstem and dorsal root ganglia do not have the apoptosis found in Bcl2^tm1Dlo homozygotes, and E12.5 primary telencephalic cultures show decreased cell death and no caspase 3 activation relative to those of Bcl2l1^tm1Dlo homozygotes

increased apoptosis ( J:66953 )

• E12.5 liver has increased apoptosis similar to that seen in Bcl2l1^tm1Dlo homozygotes indicating no requirement for caspase 9 in liver apoptotis

nervous system

abnormal telencephalon development ( J:66953 )

• E12.5 histology shows thickened telencephalic vesicle, expanded ventricular zones, and cortical dysplasia

exencephaly ( J:66953 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23