Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
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immune system
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N |
• mice exhibit normal experimental autoimmune uveitis
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• monocyte rolling velocity is increased compared to in wild-type cells
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• DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice
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digestive/alimentary system
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• DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice
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cellular
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• monocyte rolling velocity is increased compared to in wild-type cells
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hematopoietic system
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• monocyte rolling velocity is increased compared to in wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
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mortality/aging
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• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice
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immune system
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• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
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• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
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• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
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• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
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• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
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• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
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• resorptive capacity of osteoclasts is decreased compared to wild-type cells
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• 10-fold in the central nervous system of mouse hepatitis virus (MHV-V5A13.1)-infected mice
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• Th1 response to MHV-V5A13.1 infection is decreased compared to in wild-type mice
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• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality and viral recovery from the brain and decreased infiltration of T cells and microglia/macrophage in the central nervous system (CNS), IFN-gamma levels in the CNS, and demyelination compared with similarly treated wild-type mice
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• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice
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skeleton
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• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
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• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
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• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
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• resorptive capacity of osteoclasts is decreased compared to wild-type cells
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• ovariectomized mice do not exhibit a change in bone marrow density unlike in similarly treated wild-type mice
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• mice exhibit a greater increase in trabecular bone volume fraction between 6 weeks and 10 weeks compared to in wild-type mice
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• at 10 weeks, trabecular separation is decreased compared to in controls
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• mice exhibit an increase in force-to-failure values compared with wild-type mice
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neoplasm
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• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
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nervous system
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• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
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hematopoietic system
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• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
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• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
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• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
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• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
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• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
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• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
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• resorptive capacity of osteoclasts is decreased compared to wild-type cells
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cellular
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• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
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• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
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immune system
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• 7/4bri and 7/4dim cells in the blood are decreased even after mice are fed a high fat diet
• intraperitoneal thioglycollate challenge leads to an increase in 7/4bri cells
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hematopoietic system
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• 7/4bri and 7/4dim cells in the blood are decreased even after mice are fed a high fat diet
• intraperitoneal thioglycollate challenge leads to an increase in 7/4bri cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
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immune system
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• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice
• however, the number of resident macrophage in mice is normal
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• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells
(J:44345)
• however, migration in response to MIP-1alpha is normal
(J:44345)
• following injection of [3H]FC cat LDL into muscles
(J:81363)
• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells
(J:121703)
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal
(J:121703)
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• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice
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• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice
• however, proliferation in response to ConA or anti-CD3 antibodies is normal
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• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice
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• Langerhan cell repopulation after skin irradiation is impaired in these mice
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• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis
(J:44345)
• in splenocytes treated with ConA
(J:44345)
• in T cells and splenocytes from MOGp35-55 treated mice
(J:75838)
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• in the livers of mice subjected to acute challenge with acetaminophen (APAP)
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• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis
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• in splenocytes from MOGp35-55 treated mice
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• in the livers of mice subjected to acute challenge with acetaminophen (APAP)
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• MOGp35-55-treated mice fail to develop experimental autoimmune encephalomyelitis and exhibit no increase in chemokine production, reduced T cell and splenocyte proliferation, decreased IL6 production in splenocytes, and reduced IFN-gamma production in T cells and splenocytes compared with similarly treated wild-type mice
• however, monocyte recruitment in mice immunized with CFA beads is normal
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• mice exposed to purified protein derivative (PPD) of Mycobacterium bovis produce smaller granulomas with fewer macrophages, no monocytosis, and decreased IFN-gamma and IL2 production compared with similarly treated wild-type mice
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• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response, increased lung MCP-1 levels, and no histamine release compared with similarly treated wild-type mice
• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice
• however, eosinophil accumulation is normal
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homeostasis/metabolism
liver/biliary system
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• in mice subjected to acute challenge with acetaminophen (APAP)
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• in mice subjected to acute challenge with acetaminophen (APAP)
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• in mice subjected to acute challenge with acetaminophen (APAP)
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cardiovascular system
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• in mice subjected to acute challenge with acetaminophen (APAP)
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respiratory system
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• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response compared with similarly treated wild-type mice
• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice
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hematopoietic system
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• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice
• however, the number of resident macrophage in mice is normal
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• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells
(J:44345)
• however, migration in response to MIP-1alpha is normal
(J:44345)
• following injection of [3H]FC cat LDL into muscles
(J:81363)
• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells
(J:121703)
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal
(J:121703)
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• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice
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• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice
• however, proliferation in response to ConA or anti-CD3 antibodies is normal
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• colony-forming unit granulocyte macrophage fail to form in response to mJE and hMCP-1 stimulation of bone marrow cells unlike similarly treated wild-type cells
• however, the number of progenitor cells in the marrow, spleen, and peripheral blood is normal
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• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice
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nervous system
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• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice
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cellular
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• in mice subjected to acute challenge with acetaminophen (APAP)
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• in mice subjected to acute challenge with acetaminophen (APAP)
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• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice
• however, the number of resident macrophage in mice is normal
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• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells
(J:44345)
• however, migration in response to MIP-1alpha is normal
(J:44345)
• following injection of [3H]FC cat LDL into muscles
(J:81363)
• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells
(J:121703)
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal
(J:121703)
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• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice
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• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice
• however, proliferation in response to ConA or anti-CD3 antibodies is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
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cardiovascular system
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• cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice
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homeostasis/metabolism
Allelic
Composition |
Ccr2tm1Ifc/Ccr2+
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Genetic
Background |
involves: 129S4/SvJae * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
|
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immune system
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• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal
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cellular
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• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal
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hematopoietic system
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• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal
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cardiovascular system
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• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoetm1Unc homozygotes
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hematopoietic system
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• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes
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immune system
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• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes
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cardiovascular system
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• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoetm1Unc homozygotes and Apoetm1Unc Ccr2tm1Ifc homozygotes
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hematopoietic system
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• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes
• however, levels are the same as in Apoetm1Unc Ccr2tm1Ifc homozygotes
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immune system
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• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes
• however, levels are the same as in Apoetm1Unc Ccr2tm1Ifc homozygotes
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cardiovascular system
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• atherosclerotic lesions in mice fed a high fat diet for 5 weeks are smaller than in similarly treated Apoetm1Unc homozygotes
• however, no difference was observed at later time points
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cardiovascular system
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• in mice fed a high fat diet for 5, 9, and 13 weeks, atherosclerotic lesions are smaller than in similarly treated Apoetm1Unc homozygotes
• however, serum cholesterol levels are the same as in Apoetm1Unc homozygotes
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immune system
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• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes
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cellular
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• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes
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hematopoietic system
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• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
Tg(APPSWE)2576Kha mutation
(5 available)
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mortality/aging
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• by 130 days, 85% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2tm1Ifc homozygotes
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nervous system
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• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha
• however, microglial proliferation and responses to beta-amyloid are normal
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• at P65 without classic plaques
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immune system
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• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha
• however, microglial proliferation and responses to beta-amyloid are normal
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cardiovascular system
hematopoietic system
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• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha
• however, microglial proliferation and responses to beta-amyloid are normal
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation
(1 available);
any
Ccr2 mutation
(40 available)
Tg(APPSWE)2576Kha mutation
(5 available)
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mortality/aging
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• by 130 days, 60% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2tm1Ifc homozygotes
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Analysis Tools