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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ccr2tm1Ifc
targeted mutation 1, Israel F Charo
MGI:2158213
Summary 12 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ccr2tm1Ifc/Ccr2tm1Ifc B6.129S4-Ccr2tm1Ifc MGI:4833681
hm2
Ccr2tm1Ifc/Ccr2tm1Ifc B6.129S4-Ccr2tm1Ifc/J MGI:3580323
hm3
Ccr2tm1Ifc/Ccr2tm1Ifc involves: 129S4/SvJae MGI:3712665
hm4
Ccr2tm1Ifc/Ccr2tm1Ifc involves: 129S4/SvJae * C57BL/6 MGI:4831132
hm5
Ccr2tm1Ifc/Ccr2tm1Ifc involves: 129S4/SvJae * C57BL/6J MGI:4831167
ht6
Ccr2tm1Ifc/Ccr2+ involves: 129S4/SvJae * C57BL/6 MGI:4831170
cx7
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
B6.Cg-Apoetm1Unc Ccr2tm1Ifc MGI:4833679
cx8
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
Cx3cl1tm1Lira/Cx3cl1tm1Lira
B6.Cg-Apoetm1Unc Cx3cl1tm1Lira Ccr2tm1Ifc MGI:4833678
cx9
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2+
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4831159
cx10
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 MGI:4831158
cx11
Ccr2tm1Ifc/Ccr2tm1Ifc
Tg(APPSWE)2576Kha/0
involves: 129S4/SvJae * C57BL/6 * SJL MGI:4831169
cx12
Ccr2tm1Ifc/Ccr2+
Tg(APPSWE)2576Kha/0
involves: 129S4/SvJae * C57BL/6 * SJL MGI:4831171


Genotype
MGI:4833681
hm1
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
B6.129S4-Ccr2tm1Ifc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• mice exhibit normal experimental autoimmune uveitis
• monocyte rolling velocity is increased compared to in wild-type cells
• DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice

digestive/alimentary system
• DDS-treated mice fail to recruit macrophages and exhibit less colon shortening, weight loss, and clinical disease compared with similarly treated wild-type mice

cellular
• monocyte rolling velocity is increased compared to in wild-type cells

hematopoietic system
• monocyte rolling velocity is increased compared to in wild-type cells




Genotype
MGI:3580323
hm2
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
B6.129S4-Ccr2tm1Ifc/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

immune system
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• resorptive capacity of osteoclasts is decreased compared to wild-type cells
• 10-fold in the central nervous system of mouse hepatitis virus (MHV-V5A13.1)-infected mice
• Th1 response to MHV-V5A13.1 infection is decreased compared to in wild-type mice
• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality and viral recovery from the brain and decreased infiltration of T cells and microglia/macrophage in the central nervous system (CNS), IFN-gamma levels in the CNS, and demyelination compared with similarly treated wild-type mice
• mouse hepatitis virus (MHV-V5A13.1)-infected mice exhibit increased mortality compared with similarly treated wild-type mice

skeleton
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
• resorptive capacity of osteoclasts is decreased compared to wild-type cells
• ovariectomized mice do not exhibit a change in bone marrow density unlike in similarly treated wild-type mice
• mice exhibit a greater increase in trabecular bone volume fraction between 6 weeks and 10 weeks compared to in wild-type mice
• at 10 weeks, trabecular separation is decreased compared to in controls
• mice exhibit an increase in force-to-failure values compared with wild-type mice

neoplasm
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells

nervous system
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice

hematopoietic system
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• ovariectomized mice do not exhibit a change in osteoclast numbers unlike in similarly treated wild-type mice
• osteoclast number, covered bone surface, and size are decreased compared to in wild-type mice
• in tumor models, myeloid suppressor cells exhibit 20- and 8-fold reduction migration into tumors and the spleen, respectively, compared with wild-type cells
• myeloid suppressor cells fail to promote growth of B16 melanoma cells when transplanted into wild-type mice unlike wild-type myeloid suppressor cells
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice
• resorptive capacity of osteoclasts is decreased compared to wild-type cells

cellular
• osteoclastogenesis from bone marrow macrophages is less extensive than from wild-type cells
• osteoclasts derived from bone marrow macrophages are smaller with fewer nuclei than cells derived from wild-type bone marrow macrophages
• differentiation of preosteoclasts in ovariectomized mice is impaired compared to in wild-type mice
• in mouse hepatitis virus (MHV-V5A13.1)-infected mice , T cells and microglia/macrophage infiltration of the central nervous system is decreased compared to in similarly treated wild-type mice




Genotype
MGI:3712665
hm3
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• 7/4bri and 7/4dim cells in the blood are decreased even after mice are fed a high fat diet
• intraperitoneal thioglycollate challenge leads to an increase in 7/4bri cells

hematopoietic system
• 7/4bri and 7/4dim cells in the blood are decreased even after mice are fed a high fat diet
• intraperitoneal thioglycollate challenge leads to an increase in 7/4bri cells




Genotype
MGI:4831132
hm4
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice
• however, the number of resident macrophage in mice is normal
• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)
• however, migration in response to MIP-1alpha is normal (J:44345)
• following injection of [3H]FC cat LDL into muscles (J:81363)
• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)
• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice
• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice
• however, proliferation in response to ConA or anti-CD3 antibodies is normal
• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice
• Langerhan cell repopulation after skin irradiation is impaired in these mice
• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis (J:44345)
• in splenocytes treated with ConA (J:44345)
• in T cells and splenocytes from MOGp35-55 treated mice (J:75838)
• in the livers of mice subjected to acute challenge with acetaminophen (APAP)
• in mice exposed to purified protein derivative (PPD) from Mycobacterium bovis
• in splenocytes from MOGp35-55 treated mice
• in the livers of mice subjected to acute challenge with acetaminophen (APAP)
• MOGp35-55-treated mice fail to develop experimental autoimmune encephalomyelitis and exhibit no increase in chemokine production, reduced T cell and splenocyte proliferation, decreased IL6 production in splenocytes, and reduced IFN-gamma production in T cells and splenocytes compared with similarly treated wild-type mice
• however, monocyte recruitment in mice immunized with CFA beads is normal
• mice exposed to purified protein derivative (PPD) of Mycobacterium bovis produce smaller granulomas with fewer macrophages, no monocytosis, and decreased IFN-gamma and IL2 production compared with similarly treated wild-type mice
• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response, increased lung MCP-1 levels, and no histamine release compared with similarly treated wild-type mice
• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice
• however, eosinophil accumulation is normal

homeostasis/metabolism
• 120-fold above baseline in mice subjected to acute challenge with acetaminophen (APAP)
• although serum levels of total and HDL cholesterol and phospholipids are slightly lower than in wild-type mice the difference was not statistically significant
• cholesterol egress from muscles injected with [3H]FC cat LDL is slower than in similarly treated wild-type muscle due to a decrease in cholesteryl ester hydrolysis
• mice subjected to acute challenge with acetaminophen (APAP) exhibit liver necrosis/apoptosis, liver hemorrhage, and increased hepatic MCP-1, IFN-gamma, and TNF-alpha levels compared with similarly treated wild-type mice
• however, IL13 hepatic production in response to APAP is normal and immunoneutralization of IFN-gamma or TNF-alpha attenuates hepatotoxicity induced by APAP

liver/biliary system
• in mice subjected to acute challenge with acetaminophen (APAP)
• in mice subjected to acute challenge with acetaminophen (APAP)
• in mice subjected to acute challenge with acetaminophen (APAP)

cardiovascular system
• in mice subjected to acute challenge with acetaminophen (APAP)

respiratory system
• mice sensitized and challenged with cockroach allergen exhibit attenuated airway hyperreactivity response compared with similarly treated wild-type mice
• mice treated MCP-1 exhibit decreased airway hyperreactivity response compared with similarly treated wild-type mice

hematopoietic system
• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice
• however, the number of resident macrophage in mice is normal
• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)
• however, migration in response to MIP-1alpha is normal (J:44345)
• following injection of [3H]FC cat LDL into muscles (J:81363)
• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)
• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice
• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice
• however, proliferation in response to ConA or anti-CD3 antibodies is normal
• colony-forming unit granulocyte macrophage fail to form in response to mJE and hMCP-1 stimulation of bone marrow cells unlike similarly treated wild-type cells
• however, the number of progenitor cells in the marrow, spleen, and peripheral blood is normal
• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

nervous system
• microglia fail to accumulate at the site of beta-amyloid injection unlike in similarly treated wild-type mice

cellular
• in mice subjected to acute challenge with acetaminophen (APAP)
• in mice subjected to acute challenge with acetaminophen (APAP)
• fewer thioglycollate-elicited macrophages are recovered compared to in similarly treated wild-type mice
• however, the number of resident macrophage in mice is normal
• in response to CCR2 agonists, macrophage migration is impaired compared with similarly treated wild-type cells (J:44345)
• however, migration in response to MIP-1alpha is normal (J:44345)
• following injection of [3H]FC cat LDL into muscles (J:81363)
• macrophages fail to migrate in response to CCl2 unlike similarly treated wild-type cells (J:121703)
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal (J:121703)
• T cells from mice treated with MOGp35-55 exhibit 2 times less proliferation compared with T cells from similarly treated wild-type mice
• splenocytes from mice treated with MOGp35-55 exhibit less proliferation than cells from similarly treated wild-type mice
• however, proliferation in response to ConA or anti-CD3 antibodies is normal




Genotype
MGI:4831167
hm5
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice

homeostasis/metabolism
• cuff-induced neointimal hyperplasia is reduced compared to in similarly treated wild-type mice




Genotype
MGI:4831170
ht6
Allelic
Composition
Ccr2tm1Ifc/Ccr2+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal

cellular
• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal

hematopoietic system
• macrophages migrate in response to CCl2 is decreased unlike with similarly treated wild-type cells
• however, macrophage migration in response to CCL3, CCR1, and CCR5 is normal




Genotype
MGI:4833679
cx7
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
B6.Cg-Apoetm1Unc Ccr2tm1Ifc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (31 available); any Apoe mutation (97 available)
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoetm1Unc homozygotes

hematopoietic system
• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes

immune system
• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes




Genotype
MGI:4833678
cx8
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
Cx3cl1tm1Lira/Cx3cl1tm1Lira
Genetic
Background
B6.Cg-Apoetm1Unc Cx3cl1tm1Lira Ccr2tm1Ifc
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (31 available); any Apoe mutation (97 available)
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
Cx3cl1tm1Lira mutation (0 available); any Cx3cl1 mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice fed a high fat diet exhibit decreased lesion size and macrophage accumulation compared to in Apoetm1Unc homozygotes and Apoetm1Unc Ccr2tm1Ifc homozygotes

hematopoietic system
• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes
• however, levels are the same as in Apoetm1Unc Ccr2tm1Ifc homozygotes

immune system
• mice fed a high fat diet exhibit decreased circulating monocyte numbers compared to in Apoetm1Unc homozygotes
• however, levels are the same as in Apoetm1Unc Ccr2tm1Ifc homozygotes




Genotype
MGI:4831159
cx9
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (31 available); any Apoe mutation (97 available)
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atherosclerotic lesions in mice fed a high fat diet for 5 weeks are smaller than in similarly treated Apoetm1Unc homozygotes
• however, no difference was observed at later time points




Genotype
MGI:4831158
cx10
Allelic
Composition
Apoetm1Unc/Apoetm1Unc
Ccr2tm1Ifc/Ccr2tm1Ifc
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (31 available); any Apoe mutation (97 available)
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• in mice fed a high fat diet for 5, 9, and 13 weeks, atherosclerotic lesions are smaller than in similarly treated Apoetm1Unc homozygotes
• however, serum cholesterol levels are the same as in Apoetm1Unc homozygotes

immune system
• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes

cellular
• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes

hematopoietic system
• fewer macrophages in mice fed a high fat diet are present in the aorta compared to in similarly treated Apoetm1Unc homozygotes




Genotype
MGI:4831169
cx11
Allelic
Composition
Ccr2tm1Ifc/Ccr2tm1Ifc
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
Tg(APPSWE)2576Kha mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 130 days, 85% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2tm1Ifc homozygotes

nervous system
• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha
• however, microglial proliferation and responses to beta-amyloid are normal
• at P65 without classic plaques

immune system
• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha
• however, microglial proliferation and responses to beta-amyloid are normal

cardiovascular system

hematopoietic system
• microglia accumulation is impaired compared to in mice expressing Tg(APPSWE)2576Kha
• however, microglial proliferation and responses to beta-amyloid are normal

homeostasis/metabolism
• at P65, accumulation of beta-amyloid 1-42 and 1-40 in the brain are 2.4-fold and 1.4-fold respectively compared to in mice expressing Tg(APPSWE)2576Kha
• at P65 without classic plaques




Genotype
MGI:4831171
cx12
Allelic
Composition
Ccr2tm1Ifc/Ccr2+
Tg(APPSWE)2576Kha/0
Genetic
Background
involves: 129S4/SvJae * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr2tm1Ifc mutation (1 available); any Ccr2 mutation (23 available)
Tg(APPSWE)2576Kha mutation (5 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• by 130 days, 60% of mice are dead compared with 30% of mice expressing Tg(APPSWE)2576Kha, 1% of wild-type mice, and 3% of Ccr2tm1Ifc homozygotes





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last database update
01/14/2020
MGI 6.14
The Jackson Laboratory