All Phenotypes Apobec1<tm1Chan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Apobec1^tm1Chan
targeted mutation 1, Lawrence Chan
MGI:2157210

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apobec1^tm1Chan/Apobec1^tm1Chan	involves: 129S4/SvJae * C57BL/6	MGI:3850533
cx2	Apobec1^tm1Chan/Apobec1^tm1Chan Apoe^tm1Unc/Apoe^tm1Unc	involves: 129P2/OlaHsd * 129S4/SvJae	MGI:3850552
cx3	Apobec1^tm1Chan/Apobec1^tm1Chan Ldlr^tm1Her/Ldlr^tm1Her	involves: 129S4/SvJae * 129S7/SvEvBrd	MGI:3850551
cx4	Apobec1^tm1Chan/Apobec1^tm1Chan Tg(CETP)5203Tall/0	involves: 129S4/SvJae * C57BL/6J * CBA/J	MGI:3850550

Allelic Composition	Apobec1^tm1Chan/Apobec1^tm1Chan
Genetic Background	involves: 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1^tm1Chan mutation (0 available); any Apobec1 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating HDL cholesterol level ( J:36051 )

Allelic Composition	Apobec1^tm1Chan/Apobec1^tm1Chan Apoe^tm1Unc/Apoe^tm1Unc
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1^tm1Chan mutation (0 available); any Apobec1 mutation (27 available)
Apoe^tm1Unc mutation (33 available); any Apoe mutation (145 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:48202 )

• circulating VLDL/LDL cholesterol levels are decreased compared to in Apoe^tm1Unc homozygotes

• circulating VLDL/LDL cholesterol levels are increased compared to in Apobec1^tm1Chan homozygotes and wild-type mice

decreased circulating cholesterol level ( J:48202 )

• when fed a chow, mice exhibit decreased total serum cholesterol compared with Apoe^tm1Unc homozygotes

increased circulating cholesterol level ( J:48202 )

• when fed a chow or a Western-type diet for 2 or 4 weeks, mice exhibit decreased total serum cholesterol compared with Apobec1^tm1Chan homozygotes and wild-type mice

increased circulating triglyceride level ( J:48202 )

• when fed a chow diet or a Western-type diet for 2 or 4 weeks, serum triglyceride is higher than in wild-type mice

• when fed a Western-type diet for 2 or 4 weeks, mice exhibit increased serum triglyceride compared with Apobec1^tm1Chan or Apoe^tm1Unc homozygotes

• when fed a Western-type diet for 10 weeks, mice exhibit increased serum triglyceride compared with Apoe^tm1Unc homozygotes

Allelic Composition	Apobec1^tm1Chan/Apobec1^tm1Chan Ldlr^tm1Her/Ldlr^tm1Her
Genetic Background	involves: 129S4/SvJae * 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1^tm1Chan mutation (0 available); any Apobec1 mutation (27 available)
Ldlr^tm1Her mutation (19 available); any Ldlr mutation (76 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:48202 )

• circulating VLDL/LDL cholesterol levels are increased compared to in Ldlr^tm1Her homozygotes, Apobec1^tm1Chan homozygotes, and wild-type mice

increased circulating cholesterol level ( J:48202 )

• when fed a chow diet or Western-type diet for 2 and 4 weeks, mice exhibit increased serum cholesterol levels compared with Ldlr^tm1Her homozygotes, Apobec1^tm1Chan homozygotes, and wild-type mice

• when fed a Western-type diet for 14 weeks, mice exhibit higher serum cholesterol levels compared with Ldlr^tm1Her homozygotes

decreased circulating triglyceride level ( J:48202 )

• when fed a Western-type diet for 2 weeks, serum triglyceride levels are less than in Ldlr^tm1Her homozygotes

increased circulating triglyceride level ( J:48202 )

• when fed a chow diet or a high fat diet for 2 and 4 weeks, mice exhibit a decrease in serum triglyceride levels compared with Apobec1^tm1Chan homozygotes and wild-type mice

Allelic Composition	Apobec1^tm1Chan/Apobec1^tm1Chan Tg(CETP)5203Tall/0
Genetic Background	involves: 129S4/SvJae * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apobec1^tm1Chan mutation (0 available); any Apobec1 mutation (27 available)
Tg(CETP)5203Tall mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating cholesterol level ( J:48202 )

• circulating VLDL/LDL cholesterol levels are increased compared to in Tg(CETP)5203Tall mice, Apobec1^tm1Chan homozygotes, and wild-type mice

decreased circulating HDL cholesterol level ( J:48202 )

• compared to in Apobec1^tm1Chan homozygotes and wild-type mice

increased circulating cholesterol level ( J:48202 )

• after 4 and 16 weeks on a Western-type diet compared to in Tg(CETP)5203Tall mice

decreased circulating triglyceride level ( J:48202 )

• after 2 on a Western-type diet compared to in Apobec1^tm1Chan homozygotes

increased circulating triglyceride level ( J:48202 )

• mice exhibit increased serum triglyceride levels compared with wild-type mice

• after 2 on a Western-type diet, mice exhibit an increase in serum triglyceride levels compared with Tg(CETP)5203Tall mice

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