All Phenotypes Pax6<3Neu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax6^3Neu
3, Neuherberg
MGI:2156742

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pax6^3Neu/Pax6^3Neu	either: (involves: 102 * C3H) or (involves: C3H)	MGI:2173412
ht2	Pax6^3Neu/Pax6⁺	either: (involves: 102 * C3H) or (involves: C3H)	MGI:3590307
ht3	Pax6^3Neu/Pax6⁺	involves: 102 * C3H	MGI:4943211

Allelic Composition	Pax6^3Neu/Pax6^3Neu
Genetic Background	either: (involves: 102 * C3H) or (involves: C3H)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^3Neu mutation (1 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:73625 )

• severe craniofacial defects

vision/eye

anophthalmia ( J:73625 )

Allelic Composition	Pax6^3Neu/Pax6⁺
Genetic Background	either: (involves: 102 * C3H) or (involves: C3H)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^3Neu mutation (1 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

irregularly shaped pupil ( J:73625 )

• triangular shape

anterior iris synechia ( J:63651 )

corneal opacity ( J:21950 )

fused cornea and lens ( J:21950 )

• corneal lens attachment

cataract ( J:63651 )

anterior polar cataract ( J:21950 )

• anterior polar opacity

microphthalmia ( J:63651 , J:73625 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Peters anomaly		DOID:0060673	OMIM:604229	J:73625

Allelic Composition	Pax6^3Neu/Pax6⁺
Genetic Background	involves: 102 * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^3Neu mutation (1 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

corneal opacity ( J:151902 )

fused cornea and lens ( J:151902 )

microphthalmia ( J:151902 )

• mice exhibit hypoplasia in the telencephalic frontal area compared with wild-type mice

eye opacity ( J:151902 )

• central

nervous system

abnormal forebrain morphology ( J:151902 )

• mice exhibit reduced diameter of the marginal zone in the dorsal pallial region compared with wild-type mice

abnormal cortical ventricular zone morphology ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

telencephalon hypoplasia ( J:151902 )

abnormal postnatal subventricular zone morphology ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

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