hm1

Pax6^3Neu/Pax6^3Neu
either: (involves: 102 * C3H) or (involves: C3H)

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

craniofacial

abnormal craniofacial morphology ( J:73625 )

• severe craniofacial defects

vision/eye

anophthalmia ( J:73625 )

ht2

Pax6^3Neu/Pax6⁺
either: (involves: 102 * C3H) or (involves: C3H)

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	Euro	Europhenome
N	normal phenotype

vision/eye

irregularly shaped pupil ( J:73625 )

• triangular shape

abnormal cornea morphology ( J:21950 )

• corneal lens attachment

anterior iris synechia ( J:63651 )

corneal opacity ( J:21950 )

cataracts ( J:63651 )

anterior polar cataracts ( J:21950 )

• anterior polar opacity

microphthalmia ( J:63651 , J:73625 )

Mouse Models of Human Disease	OMIM ID	Ref(s)
Aniridia; AN	106210	J:73625
Anterior Segment Mesenchymal Dysgenesis; ASMD	107250	J:73625

vision/eye

corneal opacity ( J:151902 )

fused cornea and lens ( J:151902 )

microphthalmia ( J:151902 )

• mice exhibit hypoplasia in the telencephalic frontal area compared with wild-type mice

eye opacity ( J:151902 )

• central

nervous system

abnormal forebrain morphology ( J:151902 )

• mice exhibit reduced diameter of the marginal zone in the dorsal pallial region compared with wild-type mice

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice

telencephalon hypoplasia ( J:151902 )

• mice exhibit increased diameter of the ventricular and subventricular zone compared with wild-type mice