All Phenotypes Ednrb<s-9ThW> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ednrb^s-9ThW
irradiation induced 9ThW
MGI:2155855

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ednrb^s-9ThW/Ednrb^s-9ThW	involves: 101/Rl * C3H/Rl	MGI:3850347
ht2	Ednrb^s-9ThW/Ednrb⁺	involves: 101/Rl * C3H/Rl	MGI:3850346
ht3	Ednrb^s/Ednrb^s-9ThW	involves: 101/Rl * C3H/Rl	MGI:3850344
ht4	Ednrb^s-1Acrg/Ednrb^s-9ThW	involves: 101/Rl * C3H/Rl * C57BL/6J	MGI:3760668

Allelic Composition	Ednrb^s-9ThW/Ednrb^s-9ThW
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-9ThW mutation (1 available); any Ednrb mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:100221 )

Allelic Composition	Ednrb^s-9ThW/Ednrb⁺
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-9ThW mutation (1 available); any Ednrb mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

Allelic Composition	Ednrb^s/Ednrb^s-9ThW
Genetic Background	involves: 101/Rl * C3H/Rl

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s mutation (19 available); any Ednrb mutation (103 available)
Ednrb^s-9ThW mutation (1 available); any Ednrb mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:100221 )

• described as small and runted

pigmentation

white spotting ( J:100221 )

integument

white spotting ( J:100221 )

Allelic Composition	Ednrb^s-1Acrg/Ednrb^s-9ThW
Genetic Background	involves: 101/Rl * C3H/Rl * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ednrb^s-1Acrg mutation (0 available); any Ednrb mutation (103 available)
Ednrb^s-9ThW mutation (1 available); any Ednrb mutation (103 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal diaphragm morphology ( J:87686 )

• motor neuron innervation of the diaphragm is incomplete

• sensory neurons in the diaphragm are smaller and exhibit either increased branching or defasiculation

nervous system

abnormal neuromuscular synapse morphology ( J:87686 )

• at E14.5, neuromuscular junctions (NMJ) are only modestly malformed

• at E18.5, NMJs contain nerve endings that overshoot the postsynaptic receptor plaque results in a lack of muscle stimulation and possess sprouts with varicose endings

abnormal phrenic nerve morphology ( J:87686 )

• motor neuron innervation of the diaphragm is incomplete

• sensory neurons in the diaphragm are smaller and exhibit either increased branching or defasiculation

• the phrenic nerve is decreased in diameter and consists of fewer axons compared to wild-type mice

• at E14.5, ingrowing nerves have abnormal endings with large varicosities at the end of the axons

respiratory system

respiratory distress ( J:87686 )

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