All Phenotypes Tfeb<tm1Est> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tfeb^tm1Est
targeted mutation 1, Eirikur Steingrimsson
MGI:2155473

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfeb^tm1Est/Tfeb^tm1Est	involves: 129S1/Sv	MGI:4455016
cx2	Tfe3^tm1Est/Tfe3^tm1Est Tfeb^tm1Est/Tfeb⁺	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:4455030
cx3	Tfeb^tm1Est/Tfeb⁺ Tfec^tm1Est/Tfec^tm1Est	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)	MGI:4455031
cx4	Mitf^Mi-wh/Mitf^Mi-wh Tfeb^tm1Est/Tfeb⁺	involves: 129S1/Sv * C57BL * C57BL/6J * DBA	MGI:4455024

Allelic Composition	Tfeb^tm1Est/Tfeb^tm1Est
Genetic Background	involves: 129S1/Sv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:89821 )

embryo

abnormal placenta morphology ( J:89821 )

• placental defects

Allelic Composition	Tfe3^tm1Est/Tfe3^tm1Est Tfeb^tm1Est/Tfeb⁺
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice exhibit normal eyes, pigment, mast cells, and osteoclasts

Allelic Composition	Tfeb^tm1Est/Tfeb⁺ Tfec^tm1Est/Tfec^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv) or (involves: 129S1/Sv * C57BL/6J)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (45 available)
Tfec^tm1Est mutation (0 available); any Tfec mutation (25 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:89821 )

• mice exhibit normal eyes, pigment, mast cells, and osteoclasts

Allelic Composition	Mitf^Mi-wh/Mitf^Mi-wh Tfeb^tm1Est/Tfeb⁺
Genetic Background	involves: 129S1/Sv * C57BL * C57BL/6J * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^Mi-wh mutation (8 available); any Mitf mutation (72 available)
Tfeb^tm1Est mutation (0 available); any Tfeb mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

skeleton phenotype ( J:89821 )

N	• mutants do not develop osteopetrosis

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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