All Phenotypes Aplp1<tm1Umu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Aplp1^tm1Umu
targeted mutation 1, Ulrike Muller
MGI:2154545

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Aplp1^tm1Umu/Aplp1^tm1Umu	involves: 129/Sv * C57BL/6	MGI:2176988
cx2	Aplp1^tm1Umu/Aplp1^tm1Umu Aplp2^tm1Dbo/Aplp2^tm1Dbo	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:2176991
cx3	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:2176990

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:65196 )

• 10% decrease in body weight at 9 weeks of age

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu Aplp2^tm1Dbo/Aplp2^tm1Dbo
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (26 available)
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:65196 )

• no obvious defect detected grossly or microscopically

• mice were born at normal Mendelian frequency (29% of 171 animals), but no surviving double mutants were found at P1, indicating that a combined deficiency results in lethality within the first day after birth

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (26 available)
App^tm2Cwe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:65196 )

• 10% decrease in body weight at 9 weeks of age

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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