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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Cdk4tm1Bbd
targeted mutation 1, Mariano Barbacid
MGI:2154520
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Cdk4tm1Bbd/Cdk4tm1Bbd involves: 129S1/Sv * 129X1/SvJ * ICR MGI:2386959
cx2
Cdk2tm1Sgo/Cdk2tm1Sgo
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:3723204
cx3
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR MGI:3054097


Genotype
MGI:2386959
hm1
Allelic
Composition
Cdk4tm1Bbd/Cdk4tm1Bbd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1Bbd mutation (0 available); any Cdk4 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• slightly lower ratio of homozygotes produced from heterozygote matings (19.6%) (J:54534)
• slightly lower ratio of homozygotes produced from heterozygote matings (19.6%) (J:54534)

growth/size/body
• smaller size noticeable at birth and progressively more noticeable with age (J:54534)
• overall reduction in size of all major organs (J:54534)
• smaller size noticeable at birth and progressively more noticeable with age (J:54534)
• overall reduction in size of all major organs (J:54534)
• adults were 50% the weight of wild-type and heterozygous controls (J:54534)
• adults were 50% the weight of wild-type and heterozygous controls (J:54534)

cellular
• serum-starved fibroblasts derived from mutant mice exhibited a delay in reaching S phase when placed in a rich environment (J:54534)
• serum-starved fibroblasts derived from mutant mice exhibited a delay in reaching S phase when placed in a rich environment (J:54534)

homeostasis/metabolism
• in adult mice (J:54534)
• in adult mice (J:54534)
• females had low circulating levels of follicle-stimulating hormone (J:54534)
• females had low circulating levels of follicle-stimulating hormone (J:54534)
• adult mice showed hypoinsulinemia (J:54534)
• adult mice showed hypoinsulinemia (J:54534)
• females had low circulating levels of progesterone (J:54534)
• females had low circulating levels of progesterone (J:54534)
• high glucose concentrations in urine (J:54534)
• high glucose concentrations in urine (J:54534)
• ketone bodies in urine (J:54534)
• ketone bodies in urine (J:54534)

reproductive system
• defect in corpus luteum formation (J:54534)
• defect in corpus luteum formation (J:54534)
(J:54534)
(J:54534)
• severe reduction in spermatozoa in older males (J:54534)
• in males with limited fertility, reduced numbers of spermatids and mature sperm cells were evident (J:54534)
• severe reduction in spermatozoa in older males (J:54534)
• in males with limited fertility, reduced numbers of spermatids and mature sperm cells were evident (J:54534)
• degeneration of primary spermatocytes (J:54534)
• degeneration of primary spermatocytes (J:54534)
• reduced numbers of Leydig cells with numerous apoptotic bodies (J:54534)
• reduced numbers of Leydig cells with numerous apoptotic bodies (J:54534)
• vacuolized Sertoli-cell cytoplasm (J:54534)
• vacuolized Sertoli-cell cytoplasm (J:54534)
• 75% reduction in size and weight of testes compared to controls (J:54534)
• 75% reduction in size and weight of testes compared to controls (J:54534)
• moderately delayed estrous cycles (J:54534)
• moderately delayed estrous cycles (J:54534)
• infertile, failed to reproduce with wild-type males (J:54534)
• infertile, failed to reproduce with wild-type males (J:54534)
• most sterile, 80% failed to induce pregnancy (J:54534)
• males that did produce offspring had small litters (3 - 6 pups) and reproduced only for a short period (2 - 3 months of age) (J:54534)
• most sterile, 80% failed to induce pregnancy (J:54534)
• males that did produce offspring had small litters (3 - 6 pups) and reproduced only for a short period (2 - 3 months of age) (J:54534)

behavior/neurological
• impaired locomotion (J:54534)
• impaired locomotion (J:54534)
• staggering (J:54534)
• staggering (J:54534)

renal/urinary system
• high glucose concentrations in urine (J:54534)
• high glucose concentrations in urine (J:54534)
• ketone bodies in urine (J:54534)
• ketone bodies in urine (J:54534)

endocrine/exocrine glands
• mice 2 months of age or older showed severe deformity and reduction in the size of the islets of the pancreas (J:54534)
• mice 2 months of age or older showed severe deformity and reduction in the size of the islets of the pancreas (J:54534)
• defect in corpus luteum formation (J:54534)
• defect in corpus luteum formation (J:54534)
(J:54534)
(J:54534)
• degeneration of primary spermatocytes (J:54534)
• degeneration of primary spermatocytes (J:54534)
• reduced numbers of Leydig cells with numerous apoptotic bodies (J:54534)
• reduced numbers of Leydig cells with numerous apoptotic bodies (J:54534)
• vacuolized Sertoli-cell cytoplasm (J:54534)
• vacuolized Sertoli-cell cytoplasm (J:54534)
• 75% reduction in size and weight of testes compared to controls (J:54534)
• 75% reduction in size and weight of testes compared to controls (J:54534)

Mouse Models of Human Disease
OMIM ID Ref(s)
Diabetes Mellitus, Insulin-Dependent; IDDM 222100 J:54534




Genotype
MGI:3723204
cx2
Allelic
Composition
Cdk2tm1Sgo/Cdk2tm1Sgo
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk2tm1Sgo mutation (1 available); any Cdk2 mutation (9 available)
Cdk4tm1Bbd mutation (0 available); any Cdk4 mutation (30 available)
Cdk6tm1Bbd mutation (1 available); any Cdk6 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice begin to die around E13.5 and all are dying by E15.5 (J:124678)
• mice begin to die around E13.5 and all are dying by E15.5 (J:124678)
• mice begin to die around E13.5 and all are dying by E15.5 (J:124678)
• mice begin to die around E13.5 and all are dying by E15.5 (J:124678)

growth/size/body
• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice (J:124678)
• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice (J:124678)

cardiovascular system
• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls (J:124678)
• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls (J:124678)
• ventricular walls are thinner than in wild-type mice due to a decrease in the number of proliferating cardiomyocytes (J:124678)
• ventricular walls are thinner than in wild-type mice due to a decrease in the number of proliferating cardiomyocytes (J:124678)

cellular
• proliferation of mouse embryonic fibroblast cells is partially compromised (J:124678)
• exiting quiescence following serum treatment is delayed (J:124678)
• proliferation of mouse embryonic fibroblast cells is partially compromised (J:124678)
• exiting quiescence following serum treatment is delayed (J:124678)

liver/biliary system
• between E12.5 and E13.5, livers exhibit a three-fold reduction in cellularity that is not accounted for by the decrease in embryo size (J:124678)
• between E12.5 and E13.5, livers exhibit a three-fold reduction in cellularity that is not accounted for by the decrease in embryo size (J:124678)

hematopoietic system
• common myeloid progenitor cells are reduced 8-fold in number (J:124678)
• common myeloid progenitor cells are reduced 8-fold in number (J:124678)

muscle
• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls (J:124678)
• the number of proliferating cardiomyocytes is decreased resulting in thin ventricular walls (J:124678)

embryogenesis
• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice (J:124678)
• between E12.5 and E13.5, embryos are 25% to 40% smaller than wild-type mice (J:124678)




Genotype
MGI:3054097
cx3
Allelic
Composition
Cdk4tm1Bbd/Cdk4tm1Bbd
Cdk6tm1Bbd/Cdk6tm1Bbd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdk4tm1Bbd mutation (0 available); any Cdk4 mutation (30 available)
Cdk6tm1Bbd mutation (1 available); any Cdk6 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• of the few homozygotes to be born alive, all were dead within a few hours of birth (J:92529)
• of the few homozygotes to be born alive, all were dead within a few hours of birth (J:92529)
• 25% of homozygotes are dead by E14.5 (J:92529)
• 50% dead by E18.5 (J:92529)
• 25% of homozygotes are dead by E14.5 (J:92529)
• 50% dead by E18.5 (J:92529)

embryogenesis
• embryos well formed but small (J:92529)
• embryos well formed but small (J:92529)

growth/size/body
• embryos well formed but small (J:92529)
• embryos well formed but small (J:92529)

hematopoietic system
• decreased numbers of erythroid precursors in the liver and few in proliferative stage (J:92529)
• lymphoid and myeloid lineage reductions are disproportionate (J:92529)
• proliferative potential of all stem cells is severely reduced (J:92529)
• decreased numbers of erythroid precursors in the liver and few in proliferative stage (J:92529)
• lymphoid and myeloid lineage reductions are disproportionate (J:92529)
• proliferative potential of all stem cells is severely reduced (J:92529)
• RBCs are megaloblastic in appearance (J:92529)
• RBCs are megaloblastic in appearance (J:92529)
• decreased peripheral RBC counts (J:92529)
• decreased peripheral RBC counts (J:92529)
• hematopoietic stem cell numbers reduced in proportion to reduced cellularity (J:92529)
• hematopoietic stem cell numbers reduced in proportion to reduced cellularity (J:92529)

liver/biliary system
• small livers with significantly reduced cellularity by E15.5 (J:92529)
• small livers with significantly reduced cellularity by E15.5 (J:92529)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory