Phenotypes associated with this allele

• Allele Symbol: Immp2l^{Tg(HLA-A/H2-D)2Enge}
• Allele Name: transgene insertion 2, Victor H Engelhard
• Allele ID: MGI:2153986
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Immp2l^Tg(HLA-A/H2-D)2Enge/0 Tg(Mt1-RET)304Ina/0	involves: BALB/c * C57BL/6 * CBA/Ca	MGI:4819158
ot2	Immp2l^Tg(HLA-A/H2-D)2Enge/?	(C57BL/6 x CBA)F1	MGI:3789090

Genotype
MGI:4819158

cx1

• Allelic Composition: Immp2l^{Tg(HLA-A/H2-D)2Enge}/0; Tg(Mt1-RET)304Ina/0
• Genetic Background: involves: BALB/c * C57BL/6 * CBA/Ca

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:130879 )

• CD8+ T cell-depleted mice exhibit shorter survival than CD8+ T cell sufficient mice

neoplasm

increased metastatic potential ( J:130879 )

• in CD8+ T cell-depleted mice compared to in CD8+ T cell sufficient mice

increased tumor incidence ( J:130879 )

• more than 85% of mice develop tumors by 4 months of age with 50% of them exhibiting several evident cutaneous nodules at day 64

• 50% of mice without vitiligo develop visible tumors at 50 days whereas median time for tumor detection in mice with vitiligo is 88 days

increased melanoma incidence ( J:130879 )

• in 95% of mice

increased organ/body region tumor incidence ( J:130879 )

• mice develop tumors on the face earlier than in the posterior part of the body (trunk, tail, leg muscles, or genitals)

increased eye tumor incidence ( J:130879 )

• tumors first appear in the eyes

pigmentation

variable depigmentation ( J:130879 )

• 39% of mice exhibit vitiligo associated with delayed appearance of cutaneous nodules

vision/eye

increased eye tumor incidence ( J:130879 )

• tumors first appear in the eyes

exophthalmos ( J:130879 )

integument

variable depigmentation ( J:130879 )

• 39% of mice exhibit vitiligo associated with delayed appearance of cutaneous nodules

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
melanoma		DOID:1909		J:130879

Genotype
MGI:3789090

ot2

• Allelic Composition: Immp2l^{Tg(HLA-A/H2-D)2Enge}/?
• Genetic Background: (C57BL/6 x CBA)F1

immune system

abnormal negative T cell selection ( J:31937 )

• T cells that recognize the human MHC-1 complex HLA-A2.1 are not negatively selected

abnormal positive T cell selection ( J:31937 )

• positive selection of T cells capable of responding to antigen presented by chimeric MHC-1 complexes is enhanced compared to selection in Tg(HLA-A2.1)1Enge mice that express human MHC-1

• the chimeric MHC Class I molecule mediates efficient positive selection of mouse T cells to provide a more complete T cell repertoire capable of recognizing peptides presented by HLA-A2.1 Class I molecules.

• The peptide epitopes presented and recognized by mouse T cells in the context of the HLA-A2.1/H2-D^d class I molecule are the same as those presented in HLA-A2.1⁺ humans.

abnormal cytotoxic T cell physiology ( J:31937 )

• CD8 T cells from influenza infected transgenic mice lyse target cells presenting influenza peptide on either human HLA-A2.1 (MHC-I) or chimeric human mouse HLA-A/H2-D (MHC-I) complexes

• CD8 T cells lyse target cells expressing the chimeric MHC-I complex with 10-fold higher efficiency compared to target cell expressing the human MHC-I complex

hematopoietic system

abnormal negative T cell selection ( J:31937 )

• T cells that recognize the human MHC-1 complex HLA-A2.1 are not negatively selected

abnormal positive T cell selection ( J:31937 )

• positive selection of T cells capable of responding to antigen presented by chimeric MHC-1 complexes is enhanced compared to selection in Tg(HLA-A2.1)1Enge mice that express human MHC-1

• the chimeric MHC Class I molecule mediates efficient positive selection of mouse T cells to provide a more complete T cell repertoire capable of recognizing peptides presented by HLA-A2.1 Class I molecules.

• The peptide epitopes presented and recognized by mouse T cells in the context of the HLA-A2.1/H2-D^d class I molecule are the same as those presented in HLA-A2.1⁺ humans.

abnormal cytotoxic T cell physiology ( J:31937 )

• CD8 T cells from influenza infected transgenic mice lyse target cells presenting influenza peptide on either human HLA-A2.1 (MHC-I) or chimeric human mouse HLA-A/H2-D (MHC-I) complexes

• CD8 T cells lyse target cells expressing the chimeric MHC-I complex with 10-fold higher efficiency compared to target cell expressing the human MHC-I complex