Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
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mortality/aging
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• Background Sensitivity: 24-25% embryonic survival; embryonic lethality increases on a 129 or C57BL/6 congenic background
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cellular
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• reduced recruitment of leukocytes into peritoneal cavity as compared to wild-type following IP challenge with ovalbumin
• numbers of monocytes, macrophages and lymphocytes recovered from the peritoneal cavity are reduced, but not neutrophils or eosinophils
• total cell numbers are not reduced
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embryo
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• more than 50% of homozygotes at E9.5 and E12.5 display chorioallantoic fusion defects
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immune system
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• blood leukocytes are elevated 1.6 and 1.4 fold at 8 months and 15 months of age, respectively
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• absolute numbers of B lymphocytes are elevated at 8 months of age
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• absolute numbers of T lymphocytes are elevated at 8 months of age
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• absolute numbers of monocytes are elevated at 8 months of age
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hematopoietic system
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• blood leukocytes are elevated 1.6 and 1.4 fold at 8 months and 15 months of age, respectively
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• absolute numbers of B lymphocytes are elevated at 8 months of age
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• absolute numbers of T lymphocytes are elevated at 8 months of age
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• absolute numbers of monocytes are elevated at 8 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
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mortality/aging
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• Background Sensitivity: 6% embryonic survival, which is lower than in mixed 129S4-C57BL/6 or 129S4-BALB/c backgrounds or on a BALB/c congenic background
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embryo
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• more than 50% of homozygotes at E9.5 and E12.5 display chorioallantoic fusion defects
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Allelic
Composition |
Vcam1tm1Dmil/Vcam1tm1Dmil
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Genetic
Background |
either: (involves: 129S4/SvJae * BALB/c) or (involves: 129S4/SvJae * C57BL/6) |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
|
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mortality/aging
|
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• Background Sensitivity: 29% embryonic survival; embryonic lethality increases on a 129 or C57BL/6 congenic background
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embryo
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• more than 50% of homozygotes at E9.5 and E12.5 display chorioallantoic fusion defects
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hematopoietic system
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• small yet significant elevation in monocytes at 2-4 months of age
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immune system
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• small yet significant elevation in monocytes at 2-4 months of age
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
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cellular
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• reduced recruitment of lymphocytes into peritoneal cavity as compared to wild-type following IP challenge with ovalbumi
• however, total cell numbers are not reduced
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cardiovascular system
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• after an 8-week cholesterol-enriched diet, whole aorta and arch lesion area is reduced by 31% and 45%, respectively, compared to double homozygous Icam1 and Ldlr mice, and by 48% and 38%, respectively, compared to single homozygous Ldlr mutant mice
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homeostasis/metabolism
immune system
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• total leukocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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• neutrophil counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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• lymphocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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• monocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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hematopoietic system
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• total leukocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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• neutrophil counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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• lymphocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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• monocyte counts are increased when mice have been on an 8-week cholesterol-enriched diet compared to homozygous Ldlr mutant mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ldlrtm1Her mutation
(19 available);
any
Ldlr mutation
(76 available)
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
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cardiovascular system
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• develop fewer early foam cell lesions in the aorta than homozygous Ldlr mice after an 8 week cholesterol-enriched diet, however cholesterol levels, lipoprotein profiles and leukocyte numbers are similar to wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Jcgr mutation
(3 available);
any
Icam1 mutation
(24 available)
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
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cellular
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• reduced recruitment of monocytes/macrophages into peritoneal cavity as compared to wild-type following IP challenge with thioglycollate
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• reduced recruitment of leukocytes into peritoneal cavity as compared to wild-type and heterozygous Vcam1tmDmil following IP challenge with ovalbumin
• numbers of monocytes, macrophages and lymphocytes recovered from the peritoneal cavity are reduced, but not neutrophils or eosinophils
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hematopoietic system
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• reduced recruitment of monocytes/macrophages into peritoneal cavity as compared to wild-type following IP challenge with thioglycollate
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immune system
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• reduced recruitment of monocytes/macrophages into peritoneal cavity as compared to wild-type following IP challenge with thioglycollate
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Icam1tm1Jcgr mutation
(3 available);
any
Icam1 mutation
(24 available)
Vcam1tm1Dmil mutation
(0 available);
any
Vcam1 mutation
(42 available)
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cellular
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• reduced recruitment of leukocytes into peritoneal cavity as compared to wild-type, but not homozygote, following IP challenge with ovalbumin
• numbers of monocytes, macrophages and lymphocytes recovered from the peritoneal cavity are reduced, but not neutrophils or eosinophils
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Analysis Tools