Phenotypes associated with this allele

• Allele Symbol: Pkd1^m1Bei
• Allele Name: mutation 1, David R Beier
• Allele ID: MGI:2152894
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pkd1^m1Bei/Pkd1^m1Bei	involves: A/J * FVB/N	MGI:2181896

Genotype
MGI:2181896

hm1

• Allelic Composition: Pkd1^m1Bei/Pkd1^m1Bei
• Genetic Background: involves: A/J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

enlarged pancreas ( J:75360 )

homeostasis/metabolism

edema ( J:75360 )

• described as severe

renal/urinary system

kidney cyst ( J:75360 , J:213263 )

• described as massively cystic by histological analysis (J:75360)

• cultured kidneys show 3-fold higher cystogenic potentials than controls and treatment of these cultures with Gant61, a small molecule GLI antagonist, or Sant2, a small molecule SMO antagonist, inhibitors reduces cystogenic potential (J:213263)

enlarged kidney ( J:75360 )

growth/size/body

enlarged pancreas ( J:75360 )

kidney cyst ( J:75360 , J:213263 )

• described as massively cystic by histological analysis (J:75360)

• cultured kidneys show 3-fold higher cystogenic potentials than controls and treatment of these cultures with Gant61, a small molecule GLI antagonist, or Sant2, a small molecule SMO antagonist, inhibitors reduces cystogenic potential (J:213263)

enlarged kidney ( J:75360 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861	OMIM:263200	J:75360