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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Npr2cn-2J
achondroplasia 2 Jackson
MGI:2152891
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Npr2cn-2J/Npr2cn-2J B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ MGI:4838146
hm2
Npr2cn-2J/Npr2cn-2J B6;CBACa-Aw-J/A-Kcnj6wv/+ MGI:2183025


Genotype
MGI:4838146
hm1
Allelic
Composition
Npr2cn-2J/Npr2cn-2J
Genetic
Background
B6;CBACa Aw-J/A-Npr2cn-2J/GrsrJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2cn-2J mutation (1 available); any Npr2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Npr2cn-2J/Npr2cn-2J mice have domed heads and shortened long bones and tail compared to controls

reproductive system
• while oocytes in late antral follicles are usually maintained at the germinal vesicle stage with arrested meiosis, 80% of those in homozygotes have already resumed meiosis




Genotype
MGI:2183025
hm2
Allelic
Composition
Npr2cn-2J/Npr2cn-2J
Genetic
Background
B6;CBACa-Aw-J/A-Kcnj6wv/+
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npr2cn-2J mutation (1 available); any Npr2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
craniofacial
• round head

limbs/digits/tail
• short, thick femurs

skeleton
N
• relatively normal vertebrae
• short, thick femurs
• disorganized growth plates
• one animal exhibited splayed ribs

growth/size/body
• round head

Mouse Models of Human Disease
OMIM ID Ref(s)
Achondroplasia; ACH 100800 J:72465





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory