Phenotypes associated with this allele

• Allele Symbol: Apoca
• Allele Name: Anterior polar cataract
• Allele ID: MGI:2152880
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apoca/Apoca	involves: 101 * C3H	MGI:2655436
ht2	Apoca/Apoca^+	involves: 101 * C3H	MGI:2655437

Genotype
MGI:2655436

hm1

• Allelic Composition: Apoca/Apoca
• Genetic Background: involves: 101 * C3H

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:6686 )

• no viable homozygotes are recovered

Genotype
MGI:2655437

ht2

• Allelic Composition: Apoca/Apoca⁺
• Genetic Background: involves: 101 * C3H

mortality/aging

prenatal lethality, incomplete penetrance ( J:6686 )

• a non-Mendelian segregation and reduced litter size indicate semilethality

vision/eye

abnormal pupil morphology ( J:6686 )

• remnants of the pupillary membrane are present

iris synechia ( J:9528 )

• frequently observe synechiae of the iris with the lens or cornea

anterior iris synechia ( J:6686 )

• synechia of the iris with the cornea is observed

corneal opacity ( J:9528 )

cataract ( J:6686 )

• opacity consists of some irregular concentric layers of varying extent at the anterior pole of the lens

• manifestation is uni- or bilateral

• there is no progression of the opacity during life

anterior polar cataract ( J:9528 )

• anterior polar opacity

reproductive system

decreased litter size ( J:6686 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract		DOID:83	OMIM:601371 OMIM:PS116200	J:9528