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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lhx5tm1Lmgd
targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI:2152620
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lhx5tm1Lmgd/Lhx5tm1Lmgd involves: 129S1/Sv * 129X1/SvJ * CD-1 MGI:2181795
cn2
En1tm2(cre)Wrst/En1+
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:3719690
cn3
Lhx1tm1Tmj/Lhx1tm4Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Tg(Nes-cre)1Kln/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3719689


Genotype
MGI:2181795
hm1
Allelic
Composition
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx5tm1Lmgd mutation (0 available); any Lhx5 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most homozygotes die within a few days of birth

nervous system
• anterior callosal axons fail to cross the midline
• postmitotic hippocampal cells are generated but fail to differentiate properly and to migrate to correct positions, resulting in abnormal hippocampal morphogenesis
• although hippocampal neural precursor cells are specified and proliferate, many of them fail to exit the cell cycle
• at E18.5, the mutant hippocampal ventricular zone is thicker than normal, consistent with an increase in proliferating BrdU-labeled cells in this region
• by E18.5, many BrdU-labeled postmitotic cells migrate out of the ventricular zone but fail to position themselves properly and form the distinctive structures of Ammon's horn and the dentate gyrus
• although postmitotic cells are initially able to acquire certain identities of neurons or glial cells, further neuronal differentiation into the various subclasses of hippocampal neurons (such as pyramidal cells, granular cells, and interneurons) is impaired in the absence of significant apoptosis
• the choroid plexus of lateral and third ventricles is absent
• entirely absent at E18.5
• absence of morphologically distinguishable structures at E18.5
• absent at E18.5
• entirely absent at E18.5

homeostasis/metabolism
• moribund homozygotes appear cyanotic, suggesting defects in respiratory control centers

cellular
• anterior callosal axons fail to cross the midline
• postmitotic hippocampal cells are generated but fail to differentiate properly and to migrate to correct positions, resulting in abnormal hippocampal morphogenesis
• although hippocampal neural precursor cells are specified and proliferate, many of them fail to exit the cell cycle




Genotype
MGI:3719690
cn2
Allelic
Composition
En1tm2(cre)Wrst/En1+
Lhx1tm1Tmj/Lhx1tm2.1Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm2(cre)Wrst mutation (1 available); any En1 mutation (22 available)
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (15 available)
Lhx1tm2.1Bhr mutation (0 available); any Lhx1 mutation (15 available)
Lhx5tm1Lmgd mutation (0 available); any Lhx5 mutation (9 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• largely absent at E18.5
• layer is absent at E18.5
• however, the external granule cell layer appears normal
• small at E18.5 compared to controls




Genotype
MGI:3719689
cn3
Allelic
Composition
Lhx1tm1Tmj/Lhx1tm4Bhr
Lhx5tm1Lmgd/Lhx5tm1Lmgd
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lhx1tm1Tmj mutation (0 available); any Lhx1 mutation (15 available)
Lhx1tm4Bhr mutation (0 available); any Lhx1 mutation (15 available)
Lhx5tm1Lmgd mutation (0 available); any Lhx5 mutation (9 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• absent at E18.5
• largely absent at E18.5
• however, granule cells are specified properly
• layer is absent at E18.5
• small at E14.5 and E18.5 compared to controls (mice with at least 1 wild-type allele)





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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory