All Phenotypes Grb2<tm1Paw> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Grb2^tm1Paw
targeted mutation 1, Tony Pawson
MGI:2152451

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Grb2^tm1Paw/Grb2^tm1Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:2679601
ht2	Grb2^tm1Paw/Grb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:2679600
ht3	Grb2^tm1Paw/Grb2⁺	involves: 129S1/Sv * 129X1/SvJ * BALB/c	MGI:3714659
ht4	Grb2^tm1Paw/Grb2^tm2Paw	involves: 129S1/Sv * 129X1/SvJ	MGI:3719995
cn5	Grb2^tm1Paw/Grb2⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Lck-cre)548Jxm/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3717275
cn6	Grb2^tm1Paw/Grb2^tm3.1Paw Tg(Nphs2-cre)1Seq/0	involves: 129S1/Sv * 129X1/SvJ	MGI:5484786
cx7	Grb2^tm1Paw/Grb2⁺ Pten^tm1Mak/Pten⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3717274
cx8	Grb2^tm1Paw/Grb2⁺ Tg(MMTV-PyVT)634Mul/?	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:2679599

Allelic Composition	Grb2^tm1Paw/Grb2^tm1Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:51424 )

• no homozygous embryos were detectable at E7.5; homozygous embryos were seen at E3.5

embryo

absent inner cell mass proliferation ( J:51424 )

• inner cell mass did not expand

abnormal endoderm development ( J:51424 )

• very few endodermal cells were detectable at E3.5 or in cultured homozygous embryos

cellular

absent inner cell mass proliferation ( J:51424 )

• inner cell mass did not expand

Allelic Composition	Grb2^tm1Paw/Grb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:51424 )

Allelic Composition	Grb2^tm1Paw/Grb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to Retroviridae infection ( J:122429 )

• mice exhibit reduced susceptibility to Friend erythroleukemia virus (FV)

• spleen size following FV infection is not as inflamed as in wild-type mice

Allelic Composition	Grb2^tm1Paw/Grb2^tm2Paw
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)
Grb2^tm2Paw mutation (0 available); any Grb2 mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:69138 )

• by E11.5 mice are no longer viable

embryo

absent second pharyngeal arch ( J:69138 )

• at E9 to E10

decreased placental labyrinth size ( J:69138 )

• placental labyrinth is reduced

failure of chorioallantoic fusion ( J:69138 )

• at E9.5 to E10.5, chorioallantoic fusion fails to occur in 32% of mice

cardiovascular system

abnormal heart development ( J:69138 )

hearing/vestibular/ear

abnormal otic vesicle development ( J:69138 )

• large clusters of pycnotic nuclei are present in greater numbers (n=15) in the otic vesicle than in wild-type mice (n=11)

• mesenchyme cells in the otic vesicle undergo more apoptosis than in wild-type mice

nervous system

abnormal facial nerve morphology ( J:69138 )

• cranial nerve VII wanders at the dorsal body edge

abnormal vagus nerve morphology ( J:69138 )

• disorganized

craniofacial

absent second pharyngeal arch ( J:69138 )

• at E9 to E10

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Pten^tm2Mak/Pten^tm2Mak Tg(Lck-cre)548Jxm/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)
Pten^tm2Mak mutation (4 available); any Pten mutation (81 available)
Tg(Lck-cre)548Jxm mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:93530 )

• thymic lymphomas develop with a mean age of onset of 60 days, similar to that seen in T cell-specific Pten homozygotes

Allelic Composition	Grb2^tm1Paw/Grb2^tm3.1Paw Tg(Nphs2-cre)1Seq/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)
Grb2^tm3.1Paw mutation (1 available); any Grb2 mutation (42 available)
Tg(Nphs2-cre)1Seq mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:195444 )

N	• mice exhibit normal podocyte development and kidney function

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Pten^tm1Mak/Pten⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)
Pten^tm1Mak mutation (1 available); any Pten mutation (81 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased adrenal gland tumor incidence ( J:93530 )

mortality/aging

mortality/aging ( J:93530 )

N	• the embryonic lethality seen in Pten^tm1Mak heterozygotes is completely rescued

neoplasm

increased tumor incidence ( J:93530 )

• develop the same tumor types at the same frequency as Pten^tm1Mak heterozygotes, including neoplastic lesions in the breast, endometrium, prostate, adrenal gland, and lymphoid organs; tumor stage, grade, and metastatic potential are similar to that in Pten^tm1Mak heterozygotes

increased adrenal gland tumor incidence ( J:93530 )

increased lymphoma incidence ( J:93530 )

increased endometrial carcinoma incidence ( J:93530 )

reproductive system

increased endometrial carcinoma incidence ( J:93530 )

Allelic Composition	Grb2^tm1Paw/Grb2⁺ Tg(MMTV-PyVT)634Mul/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Grb2^tm1Paw mutation (0 available); any Grb2 mutation (42 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

integument

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

endocrine/exocrine glands

increased mammary adenocarcinoma incidence ( J:51424 )

• delayed onset of mammary tumorigenesis compared to wild-type Grb2 mice carrying transgene

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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