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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Apoetm1Lmh
targeted mutation 1, Louis M Havekes
MGI:2152302
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Apoetm1Lmh/Apoetm1Lmh involves: 129S7/SvEvBrd * C57BL/6 MGI:2174929
ht2
Apoetm1Lmh/Apoe+ involves: 129S7/SvEvBrd * C57BL/6 MGI:2174930
cn3
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S7/SvEvBrd MGI:4943551
cn4
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
involves: 129S7/SvEvBrd * C57BL/6J * SJL MGI:3797226
cx5
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
involves: 129S7/SvEvBrd * C57BL/6 MGI:3797227


Genotype
MGI:2174929
hm1
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• 2-fold increase in serum cholesterol when fed normal chow
• 3-fold increase in serum cholesterol when fed a hypercholesterolemic diet
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• when fed a hypercholesterolemic diet for 14 weeks prior to sacrifice, 6 - 7 month old mice showed increased incidence of xanthomatous lesions in multiple tissues, including skin, salivary glands, thyroid glands, muscles, periosteum and upper mediastinum, including the thymus, mesothelium of bladder and kidney, nasal mucosa, choroids plexus, third ventricle, and meniges of the brain and the meniges of spinal cord

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:22347
NOT Sea-Blue Histiocyte Disease 269600 J:22347




Genotype
MGI:2174930
ht2
Allelic
Composition
Apoetm1Lmh/Apoe+
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (68 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning
• surface area of lesions was 6 - 30 times larger than sex-matched controls
• lesions in females larger than in males

homeostasis/metabolism
• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

Mouse Models of Human Disease
OMIM ID Ref(s)
Apolipoprotein E; APOE 107741 J:22347




Genotype
MGI:4943551
cn3
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (68 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (91 available)
Lyz2tm1(cre)Ifo mutation (7 available); any Lyz2 mutation (11 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• the total macrophage and collagen lesion contents are increased
• the percentage (normalized for lesion size) of collagen in lesions is increased; however, the percentages of macrophages and smooth muscle cells in the lesions are similar
• total atherosclerotic lesion area and the proportion of advanced lesions are significantly increased compared to mutant mice expressing Lrp1




Genotype
MGI:3797226
cn4
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (68 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
Lrp1tm2Her mutation (1 available); any Lrp1 mutation (91 available)
Tg(Mx1-cre)29-4Her mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• following pIpC treatment, plasma cholesterol level is lower compared to mutant mice wild-type for Lrp1
• following pIpC treatment, plasma LDL cholesterol level is lower compared to mutant mice wild-type for Lrp1
• following pIpC treatment, plasma VLDL cholesterol level is lower compared to mutant mice wild-type for Lrp1
• following pIpC treatment, plasma triglyceride level is lower compared to mutant mice wild-type for Lrp1
• increase in Factor VIII, von Willebrand factor, and tissue type plasminogen activator levels by 4 weeks after pIpC treatment (J:90547)
• mice show elevated FVIII (Factor 8) levels (J:117317)
• following pIpC treatment, plasma lipoprotein lipase level is higher compared to mutant mice wild-type for Lrp1
• however, no increase in lipoprotein lipase activity is detected

cardiovascular system
• increase in lesion size in pIpC treated mice compared to untreated controls
• however, no change in lesion composition is detected




Genotype
MGI:3797227
cx5
Allelic
Composition
Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Lmh mutation (0 available); any Apoe mutation (68 available)
Ldlrtm1Her mutation (18 available); any Ldlr mutation (47 available)
phenotype observed in females
phenotype observed in males
N normal phenotype




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last database update
04/26/2016
MGI 6.03
The Jackson Laboratory