Mouse Genome Informatics
hm1
    Apoetm1Lmh/Apoetm1Lmh
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• 2-fold increase in serum cholesterol when fed normal chow
• 3-fold increase in serum cholesterol when fed a hypercholesterolemic diet
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 160-fold increase in serum VLDL + LDL when fed normal chow
• when fed a hypercholesterolemic diet for 14 weeks prior to sacrifice, 6 - 7 month old mice showed increased incidence of xanthomatous lesions in multiple tissues, including skin, salivary glands, thyroid glands, muscles, periosteum and upper mediastinum, including the thymus, mesothelium of bladder and kidney, nasal mucosa, choroids plexus, third ventricle, and meniges of the brain and the meniges of spinal cord

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:22347
NOT Sea-Blue Histiocyte Disease 269600 J:22347


Mouse Genome Informatics
ht2
    Apoetm1Lmh/Apoe+
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• atherosclerosis, when fed hypercholesterolemic diet for 14 weeks after weaning
• surface area of lesions was 6 - 30 times larger than sex-matched controls
• lesions in females larger than in males

homeostasis/metabolism
• mild hypercholesterolemia when fed a hypercholesterolemic diet with 20-fold increase in serum cholesterol resulting
• no increase in HDL
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet
• 35-fold increase in serum VLDL + LDL when fed a hypercholesterolemic diet

Mouse Models of Human Disease
OMIM IDRef(s)
Apolipoprotein E; APOE 107741 J:22347


Mouse Genome Informatics
cn3
    Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Lyz2tm1(cre)Ifo/Lyz2+

involves: 129P2/OlaHsd * 129S7/SvEvBrd
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
cardiovascular system
• the total macrophage and collagen lesion contents are increased
• the percentage (normalized for lesion size) of collagen in lesions is increased; however, the percentages of macrophages and smooth muscle cells in the lesions are similar
• total atherosclerotic lesion area and the proportion of advanced lesions are significantly increased compared to mutant mice expressing Lrp1


Mouse Genome Informatics
cn4
    Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her
Lrp1tm2Her/Lrp1tm2Her
Tg(Mx1-cre)29-4Her/0

involves: 129S7/SvEvBrd * C57BL/6J * SJL
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
• following pIpC treatment, plasma cholesterol level is lower compared to mutant mice wild-type for Lrp1
• following pIpC treatment, plasma LDL cholesterol level is lower compared to mutant mice wild-type for Lrp1
• following pIpC treatment, plasma VLDL cholesterol level is lower compared to mutant mice wild-type for Lrp1
• following pIpC treatment, plasma triglyceride level is lower compared to mutant mice wild-type for Lrp1
• increase in Factor VIII, von Willebrand factor, and tissue type plasminogen activator levels by 4 weeks after pIpC treatment (J:90547)
• mice show elevated FVIII (Factor 8) levels (J:117317)
• however, no increase in lipoprotein lipase activity is detected
• following pIpC treatment, plasma lipoprotein lipase level is higher compared to mutant mice wild-type for Lrp1

cardiovascular system
• increase in lesion size in pIpC treated mice compared to untreated controls
• however, no change in lesion composition is detected


Mouse Genome Informatics
cx5
    Apoetm1Lmh/Apoetm1Lmh
Ldlrtm1Her/Ldlrtm1Her

involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
homeostasis/metabolism
N
• mice show normal FVIII (Factor 8) levels in plasma (J:117317)