All Phenotypes Hoxd13<tm1Mrc> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxd13^tm1Mrc/Hoxd13^tm1Mrc	involves: 129S7/SvEvBrd	MGI:3513188
ht2	Hoxd13^tm1Mrc/Hoxd13⁺	involves: 129S7/SvEvBrd	MGI:3513189
cx3	Hoxb13^tm1Mrc/Hoxb13^tm1Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2656751
cx4	Hoxb13^tm2Mrc/Hoxb13^tm2Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc	involves: 129S7/SvEvBrd	MGI:2656752

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

absent carpal bone ( J:32603 )

• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI

brachyphalangia ( J:32603 )

• homozygotes show a reduction or loss of phalange 2 on digits II and V

• phalangeal bones on other digits are also reduced due to abnormal segmentation

polydactyly ( J:32603 )

• homozygotes display the formation of an extra postaxial digit ("VI")

interdigital webbing ( J:32603 )

• interdigital webbing is sometimes observed

short metacarpal bones ( J:32603 )

• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

skeleton

absent carpal bone ( J:32603 )

• the d4 carpal bone is never properly formed; instead, it yields an extra carpal bone from which grows the postaxial digit VI

brachyphalangia ( J:32603 )

• homozygotes show a reduction or loss of phalange 2 on digits II and V

• phalangeal bones on other digits are also reduced due to abnormal segmentation

short metacarpal bones ( J:32603 )

• homozygotes display severe appendicular skeletal defects, including a significant reduction of metacarpal length

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:82540 )

N	• ventral prostate appears normal with no reductions in duct tip numbers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
synpolydactyly		DOID:0060242	OMIM:186000 OMIM:608180 OMIM:610234	J:32603

Allelic Composition	Hoxd13^tm1Mrc/Hoxd13⁺
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

abnormal carpal bone morphology ( J:32603 )

• heterozygotes exhibit minor carpal defects, including a slight indentation at the distal border

abnormal digit morphology ( J:32603 )

• heterozygotes display a tiny bony element located postaxially to digit V at a penetrance of 36%

skeleton

abnormal carpal bone morphology ( J:32603 )

• heterozygotes exhibit minor carpal defects, including a slight indentation at the distal border

Allelic Composition	Hoxb13^tm1Mrc/Hoxb13^tm1Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb13^tm1Mrc mutation (0 available); any Hoxb13 mutation (9 available)
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

reproductive system

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

Allelic Composition	Hoxb13^tm2Mrc/Hoxb13^tm2Mrc Hoxd13^tm1Mrc/Hoxd13^tm1Mrc
Genetic Background	involves: 129S7/SvEvBrd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hoxb13^tm2Mrc mutation (0 available); any Hoxb13 mutation (9 available)
Hoxd13^tm1Mrc mutation (0 available); any Hoxd13 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

reproductive system

abnormal prostate gland ventral lobe morphology ( J:82540 )

• 50% reduction in the number of duct tips in the ventral prostate

• outgrowth of prostate ducts is reduced

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/09/2024 MGI 6.23