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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ptentm1Rps
targeted mutation 1, Ramon Parsons
MGI:2151804
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ptentm1Rps/Ptentm1Rps involves: 129S1/Sv * C57BL/6J MGI:2179044
ht2
Ptentm1Rps/Pten+ B6.129S1-Ptentm1Rps MGI:5467726
ht3
Ptentm1Rps/Pten+ involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J MGI:5569932
ht4
Ptentm1Rps/Pten+ involves: 129S1/Sv * C57BL/6J MGI:2179045
cn5
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Ptentm1Rps/Ptentm1Rps
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129/Sv * 129S1/Sv * C57BL/6J * FVB/N * SJL MGI:4418448
cn6
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Rps/Ptentm1Rps
Tg(Tyr-cre/ERT2)13Bos/0
involves: 129/Sv * C57BL/6J * FVB * SJL MGI:4418449
cx7
Ptentm1Rps/Pten+
Slc6a4tm1Kpl/Slc6a4+
B6.129-Slc6a4tm1Kpl Ptentm1Rps MGI:5467729
cx8
Ptentm1Rps/Pten+
RictorGt(RRR347)Byg/Rictor+
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6 MGI:4848133
cx9
Ptentm1Rps/Pten+
Rptortm1Lex/Rptor+
involves: 129S/SvEvBrd * 129S1/Sv * C57BL/6 MGI:4848144
cx10
Nkx3-1tm1Mms/Nkx3-1tm1Mms
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J MGI:5569926
cx11
Nkx3-1tm1Mms/Nkx3-1+
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J MGI:5569928
cx12
MtorGt(OST92090)Lex/Mtor+
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6 MGI:4848141
cx13
Mlst8tm1Lex/Mlst8+
Ptentm1Rps/Pten+
involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6 MGI:4848146
cx14
Ptentm1Rps/Pten+
Tg(Wnt1)1Hev/0
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL MGI:5442747


Genotype
MGI:2179044
hm1
Allelic
Composition
Ptentm1Rps/Ptentm1Rps
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lethality occurs after implantation but prior to gestation, between E6.5 and E9.5
• at E6.5, abnormal embryos appear to undergo a process of resorption

embryo
• embryos appear disorganized at E6.5




Genotype
MGI:5467726
ht2
Allelic
Composition
Ptentm1Rps/Pten+
Genetic
Background
B6.129S1-Ptentm1Rps
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 12 week old females do not show preference for spending more time in the social chamber versus nonsocial chamber as wild-type mice do and spend equal time in both chambers, indicating impaired social approach behavior in females but not males
• while 8 week old males do not show a change in preference for social interaction for the first trial, upon reexposure to the same social target in trial 2, males do not show attenuation of preference for social investigation between the first and second trials as seen in wild-type mice

nervous system
• both males and females show deficits in prepulse inhibition of the acoustic startle response
• however, mice respond to the olfactory-habituation-dishabituation test normally, indicating normal olfactory function

growth/size/body
• macrocephaly in both males and females




Genotype
MGI:5569932
ht3
Allelic
Composition
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 10% of prostates and by 12 months of age, 34% of prostates are still lesion-free
• lesions show absence of Nkx3-1 protein expression

reproductive system
• prostates exhibit localized regions of severely dysplastic epithelium at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 10% of prostates and by 12 months of age, 34% of prostates are still lesion-free
• lesions show absence of Nkx3-1 protein expression

endocrine/exocrine glands
• prostates exhibit localized regions of severely dysplastic epithelium at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 10% of prostates and by 12 months of age, 34% of prostates are still lesion-free
• lesions show absence of Nkx3-1 protein expression




Genotype
MGI:2179045
ht4
Allelic
Composition
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Gut polyps and lymphoid hyperplasia in Ptentm1Rps/Pten+ mice

liver/biliary system

mortality/aging
• about 12% of older mice ranging in age from 20-56 weeks die or were sacrificed due to morbidity

neoplasm
• neoplasms in multiple organs including the endometrium, liver, prostate, gastrointestinal tract, thyroid, and thymus
• tumors of the gastrointestinal epithelium develop in association with gut lymphoid tissue
• tumors of the endometrium, thyroid, prostate, and liver are not associated with lymphoid tissue and appear highly mitotic
• the tumors that cause morbidity include lymphomas, synchronous thyroid carcinoma, liver adenoma, poorly differentiated leukemia and teratoma
• 3 of 8 males at 6-22 weeks of age display prostatic intraepithelial neoplasia; an additional 3 mice have foci of benign epithelial hyperplasia in the prostate
• poorly differentiated leukemia
• lymphomas develop in 7 of 256 mice that were clinically sick
• all mutants that develop lymphoma display diffuse microscopic infiltration of all organs by atypical immature lymphoid cells

digestive/alimentary system
• intestinal polyps are seen in all mutants from 7 to 18 weeks of age; multiple polyps frequently cluster within a single region
• most polyps are lymphoid polyps with normal epithelium; the second most frequent type of polyp is lymphoid polyps with epithelial hyperplasia

endocrine/exocrine glands
• 5 of the 7 mutants that develop lymphoma have an enlarged thymus
• 3 of 20 mutants at 6-22 weeks of age display follicular or papillary noninvasive neoplasia of the thyroid and an additional 3 mice have atypical epithelial changes in the thyroid
• 3 of 8 males at 6-22 weeks of age display prostatic intraepithelial neoplasia; an additional 3 mice have foci of benign epithelial hyperplasia in the prostate

hematopoietic system
• 5 of the 7 mutants that develop lymphoma have an enlarged thymus
• all mutants that develop lymphoma have splenomegaly
• by 50 weeks of age, all females and 45% of males have splenomegaly

immune system
• 5 of the 7 mutants that develop lymphoma have an enlarged thymus
• all mutants that develop lymphoma have splenomegaly
• by 50 weeks of age, all females and 45% of males have splenomegaly
• in the hyperplastic lymph nodes and aggregates, follicular organization is blurred with mixing of the B and T cell regions
• neoplastic hyperplasia of lymph nodes caused by a defect in apoptosis in B cells and macrophages
• expansion of the interfollicular areas, medullary cords, and residual follicular and paracortical hyperplasia composed of B, T, macrophage, and fibroblast cells

reproductive system
• 3 of 8 males at 6-22 weeks of age display prostatic intraepithelial neoplasia; an additional 3 mice have foci of benign epithelial hyperplasia in the prostate
• 100% of females aged 18-39 weeks display multifocal endometrial complex atypical hyperplasia, a lesion that is a precursor of endometrial carcinoma




Genotype
MGI:4418448
cn5
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Ptentm1Rps/Ptentm1Rps
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background
involves: 129/Sv * 129S1/Sv * C57BL/6J * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (5 available); any Cdkn2a mutation (30 available)
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
Tg(Tyr-cre/ERT2)13Bos mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• following 4-hydroxytamoxifen (4-OHT) application, all mice develop melanoma over a 9 month period unlike wild-type mice




Genotype
MGI:4418449
cn6
Allelic
Composition
Cdkn2atm1Rdp/Cdkn2atm1Rdp
Ctnnb1tm1Mmt/Ctnnb1tm1Mmt
Ptentm1Rps/Ptentm1Rps
Tg(Tyr-cre/ERT2)13Bos/0
Genetic
Background
involves: 129/Sv * C57BL/6J * FVB * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cdkn2atm1Rdp mutation (5 available); any Cdkn2a mutation (30 available)
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (27 available)
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
Tg(Tyr-cre/ERT2)13Bos mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• following 4-hydroxytamoxifen (4-OHT) application, all mice develop melanoma over a 9 month period unlike wild-type mice




Genotype
MGI:5467729
cx7
Allelic
Composition
Ptentm1Rps/Pten+
Slc6a4tm1Kpl/Slc6a4+
Genetic
Background
B6.129-Slc6a4tm1Kpl Ptentm1Rps
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
Slc6a4tm1Kpl mutation (3 available); any Slc6a4 mutation (25 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• 8 week old females show a significant decrease in preference for interacting with a stimulus mouse in a social approach assay, with mice spending significantly less time interacting with the stimulus mouse than in wild-type mice or either single heterozygote, indicating impaired social approach behavior in females
• while 8 week old males do not show a change in preference for social interaction for the first trial, upon reexposure to the same social target in trial 2, males do not show attenuation of preference for social investigation between the first and second trials as seen in wild-type mice, indicating impaired social recognition in males

nervous system
• deficits in prepulse inhibition of the acoustic startle response indicate impaired sensorimotor gating
• mice show deficits in prepulse inhibition of the acoustic startle response to a similar level as single Pten heterozygotes
• however, mice respond to the olfactory-habituation-dishabituation test normally, indicating normal olfactory function

growth/size/body
• macrocephaly that is more severe than in either single heterozygote

Mouse Models of Human Disease
OMIM ID Ref(s)
Autism 209850 J:144937




Genotype
MGI:4848133
cx8
Allelic
Composition
Ptentm1Rps/Pten+
RictorGt(RRR347)Byg/Rictor+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
RictorGt(RRR347)Byg mutation (0 available); any Rictor mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants tend to live longer than single heterozygous Pten mice

endocrine/exocrine glands
• prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

reproductive system
• prostates exhibit signs of hyperplasia but lesions are less severe than in single heterozygous Pten mice

neoplasm
• mutants are protected from prostate cancer development: only 1 of 10 double mutants developed a tumor compared to 5 of 9 single heterozygous Pten mice




Genotype
MGI:4848144
cx9
Allelic
Composition
Ptentm1Rps/Pten+
Rptortm1Lex/Rptor+
Genetic
Background
involves: 129S/SvEvBrd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
Rptortm1Lex mutation (2 available); any Rptor mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• mutants exhibit a similar lifespan as single heterozygous Pten mice




Genotype
MGI:5569926
cx10
Allelic
Composition
Nkx3-1tm1Mms/Nkx3-1tm1Mms
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1tm1Mms mutation (3 available); any Nkx3-1 mutation (10 available)
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia /early carcinoma lesions are seen in 60% of prostates and by 10 months of age, all mice show lesions
• multifocal lesions are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

reproductive system
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia /early carcinoma lesions are seen in 60% of prostates and by 10 months of age, all mice show lesions
• multifocal lesions are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

neoplasm
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia /early carcinoma lesions are seen in 60% of prostates and by 10 months of age, all mice show lesions
• multifocal lesions are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

Mouse Models of Human Disease
OMIM ID Ref(s)
Prostate Cancer 176807 J:75085




Genotype
MGI:5569928
cx11
Allelic
Composition
Nkx3-1tm1Mms/Nkx3-1+
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * 129S1/SvImJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nkx3-1tm1Mms mutation (3 available); any Nkx3-1 mutation (10 available)
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions
• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

endocrine/exocrine glands
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions
• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

neoplasm
• early carcinoma lesions are seen in the prostate at 6 months of age
• at 6 months of age, high-grade prostatic intraepithelial neoplasia/early carcinoma lesions are seen in 36% of prostates, and by 12 months, all mice show lesions
• multifocal lesions in the prostate are comprised of poorly differentiated cells with prominent and multiple nucleoli, an increased nuclear/cytoplasmic ratio, and frequent mitotic figures
• lesions usually fill the affected prostatic ducts and are highly vascularized, show an increase in cytokeratins, an absence of basal epithelium, and a high proliferative index
• lesions show absence of Nkx3-1 protein expression, although mRNA is present and allelic loss of Pten

Mouse Models of Human Disease
OMIM ID Ref(s)
Prostate Cancer 176807 J:75085




Genotype
MGI:4848141
cx12
Allelic
Composition
MtorGt(OST92090)Lex/Mtor+
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MtorGt(OST92090)Lex mutation (1 available); any Mtor mutation (57 available)
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants live longer than single heterozygous Pten mice




Genotype
MGI:4848146
cx13
Allelic
Composition
Mlst8tm1Lex/Mlst8+
Ptentm1Rps/Pten+
Genetic
Background
involves: 129S1/Sv * 129S5/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlst8tm1Lex mutation (1 available); any Mlst8 mutation (14 available)
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• double mutants live longer than single heterozygous Pten mice




Genotype
MGI:5442747
cx14
Allelic
Composition
Ptentm1Rps/Pten+
Tg(Wnt1)1Hev/0
Genetic
Background
involves: 129S1/Sv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Rps mutation (1 available); any Pten mutation (41 available)
Tg(Wnt1)1Hev mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 14 of 22 tumors in males arise in the salivary tissue
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin

digestive/alimentary system
• 14 of 22 tumors in males arise in the salivary tissue

integument
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin

neoplasm
• 50% of females develop mammary ductal carcinoma by 3.5 months of age, earlier than single Tg(Wnt1)1Hev hemizygotes, and all females show tumors by 5 months of age
• 2 of 22 tumors in males are mammary in origin
• mutants occasionally show pulmonary metastasis
• tumors are adenocarcinomas with cribiform, cystic and focal papillary growth patterns
• 50% of males develop tumors by 5.5 months and all males develop tumors within 10 months
• 50% of females develop tumors by 3.5 months of age and all females have tumors within 5 months of age
• 6 of 22 tumors in males are bilateral or unilateral muzzle tumors of epithelial origin
• 7 or 11 tumors show loss of Pten heterozygosity
• most mutants (38 of 49) develop only one palpable tumor
• 14 of 22 tumors in males arise in the salivary tissue

Mouse Models of Human Disease
OMIM ID Ref(s)
Breast Cancer 114480 J:67497





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory