All Phenotypes Scx<tm2Eno> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Scx^tm2Eno
targeted mutation 2, Eric N Olson
MGI:2151296

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scx^tm1Eno/Scx^tm2Eno	chimera involves: 129S7/SvEvBrd * C57BL/6 * Swiss	MGI:3770260

Allelic Composition	Scx^tm1Eno/Scx^tm2Eno
Genetic Background	chimera involves: 129S7/SvEvBrd * C57BL/6 * Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scx^tm1Eno mutation (0 available); any Scx mutation (12 available)
Scx^tm2Eno mutation (0 available); any Scx mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

embryo

absent somites ( J:55991 )

• in two E9.5 chimeric embryos with >95% mutant cells, discernable somites are absent and the somitic region is cell-deficient

cardiovascular system

dilated dorsal aorta ( J:55991 )

• n two E9.5 chimeric embryos with >95% mutant cells, the dorsal aortae become dilated to fill the space created by the complete loss of identifiable somites

skeleton

abnormal sclerotome morphology ( J:55991 )

• in chimeric embryos, mutant cells are unable to contribute to (i) the sclerotomal compartment of somites that gives rise to the axial skeleton at E8.5 and E9.5 and (ii) the developing ribs at E14.5 and E16.5

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