Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation
(1 available);
any
Irs4 mutation
(5 available)
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reproductive system
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• female homozygotes exhibit reduced ability to produce live offspring when mated with hemizygous mutant males
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• pairs of mutant mice produce an average of 2.0 0.5 litters per pair (range 0-3), whereas wild-type mice produce an average of 3.1 0.1 litters per pair (range 3-4)
• ~50% of mutant litters die within a few days of birth relative to only 8% of wild-type litters
• the average sizes of surviving litters are almost the same for mutant and wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation
(1 available);
any
Irs4 mutation
(5 available)
|
|
|
reproductive system
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• female homozygotes exhibit reduced ability to produce live offspring when mated with hemizygous mutant males
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• pairs of mutant mice produce an average of 1.8 0.4 litters per pair (range 0-3 litters) over a 3-month period, whereas wild-type mice produce an average of 2.9 0.1 litters per pair (range 2-3 litters)
• 36% of mutant litters die within a few days of birth relative to only 5% of wild-type litters
• the average size of surviving litters from mutant mice is slightly reduced relative to wild-type litters
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behavior/neurological
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• female homozygotes may be less nurturing of their pups than wild-type females, as suggested by an observed decrease in the number of surviving litters
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homeostasis/metabolism
growth/size/body
N |
• female homozygotes exhibit a very slight reduction in body size relative to wild-type mice; however, this difference does not reach statistical significance
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Jos mutation
(0 available);
any
Irs1 mutation
(51 available)
Irs4tm1Lhd mutation
(1 available);
any
Irs4 mutation
(5 available)
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growth/size/body
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• these mutant males display no significant differences from Irs1tm1Jos homozygous males with respect to growth or organ size
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homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm1Jos mutation
(0 available);
any
Irs1 mutation
(51 available)
Irs4tm1Lhd mutation
(1 available);
any
Irs4 mutation
(5 available)
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growth/size/body
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• double homozygous females display no significant differences from Irs1tm1Jos homozygous females with respect to growth or organ size
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homeostasis/metabolism
Allelic Composition |
Irs4tm1Lhd/Y
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Genetic Background |
involves: 129S4/SvJae * BALB/c |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation
(1 available);
any
Irs4 mutation
(5 available)
|
|
|
homeostasis/metabolism
reproductive system
|
• male hemizygotes exhibit reduced ability to produce live offspring when mated with homozygous mutant females
|
|
• pairs of mutant mice produce an average of 2.0 0.5 litters per pair (range 0-3), whereas wild-type mice produce an average of 3.1 0.1 litters per pair (range 3-4)
• ~50% of mutant litters die within a few days of birth relative to only 8% of wild-type litters
• the average sizes of surviving litters are almost the same for mutant and wild-type mice
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Allelic Composition |
Irs4tm1Lhd/Y
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Genetic Background |
involves: 129S4/SvJae * C57BL/6 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs4tm1Lhd mutation
(1 available);
any
Irs4 mutation
(5 available)
|
|
|
homeostasis/metabolism
reproductive system
|
• male hemizygotes exhibit reduced ability to produce live offspring when mated with homozygous mutant females
|
|
• pairs of mutant mice produce an average of 1.8 0.4 litters per pair (range 0-3 litters) over a 3-month period, whereas wild-type mice produce an average of 2.9 0.1 litters per pair (range 2-3 litters)
• 36% of mutant litters die within a few days of birth relative to only 5% of wild-type litters
• the average size of surviving litters from mutant mice is slightly reduced relative to wild-type litters
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growth/size/body
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• at 9 weeks and beyond, the weight of male hemizygotes is ~10% less that of wild-type mice
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• male hemizygotes exhibit a growth retardation beyond 6 weeks of age
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