Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hes5tm1Fgu mutation
(1 available);
any
Hes5 mutation
(16 available)
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vision/eye
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• somehat reduced density of Muller glial cells at 7 and 14 days of age as well as in adults
• density reduction of about 30-40%
• no increase in apoptosis
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hearing/vestibular/ear
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• doublets of inner hair cells interspersed along the single row
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• many areas with four outer hair cell rows rather than 3
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• significant increase of hair cells on sensory epithelium of utricle and saccule (but to a lesser extent)
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nervous system
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• somehat reduced density of Muller glial cells at 7 and 14 days of age as well as in adults
• density reduction of about 30-40%
• no increase in apoptosis
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• more Map2+ neurons in the brain and expression of Map2 by neurons was premature
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• doublets of inner hair cells interspersed along the single row
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• many areas with four outer hair cell rows rather than 3
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• significant increase of hair cells on sensory epithelium of utricle and saccule (but to a lesser extent)
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endocrine/exocrine glands
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• pituitary gland is sphere-shaped
• gland is composed of round cells only and lacks columnar cells
• cells expressing proopiomelanocortin (POMC) are all round, characteristic of pituitary anterior lobe cells whereas in wild-type, both round and columnar cells (in intermediate lobe) express POMC
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• growth hormone-producing cells are slightly increased in number
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• at E18, neurohypophysis is lost in mutants, but is formed normally in wild-type and Hes1-null animals
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• at E12.5, evagination of the infundibulum is affected compared to control embryos
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• at E18, there are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays
• no apoptosis is observed
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• lumen of Rathke's pouch is absent
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• at E18, pituitary gland is severely hypoplastic
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• intermediate lobe is absent
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nervous system
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• pituitary gland is sphere-shaped
• gland is composed of round cells only and lacks columnar cells
• cells expressing proopiomelanocortin (POMC) are all round, characteristic of pituitary anterior lobe cells whereas in wild-type, both round and columnar cells (in intermediate lobe) express POMC
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• growth hormone-producing cells are slightly increased in number
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• at E18, neurohypophysis is lost in mutants, but is formed normally in wild-type and Hes1-null animals
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• at E12.5, evagination of the infundibulum is affected compared to control embryos
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• at E18, there are decreased numbers of pituitary gland progenitor cells compared to wild-type, shown by proliferation assays
• no apoptosis is observed
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• lumen of Rathke's pouch is absent
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• at E18, pituitary gland is severely hypoplastic
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• intermediate lobe is absent
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nervous system
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• mice exhibit no change in Cajal-Retzius cell number
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nervous system
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• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon
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• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified
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• mice exhibit mild abnormalities in the cortical hem and cortical neuroepithelium
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• at E11.5 and E12.5, the number of Cajal-Retzius cells in the marginal zone of the piriform cortex is increased compared to in wild-type mice
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embryo
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• unlike in wild-type mice, at E11.5 and E12.5 dorsal midline cells do not flatten and remain pseudostratified
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cellular
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• mice exhibit accelerated differentiation of neurons compared to in wild-type mice, including Cajal-Retzius cells in the dorsal telencephalon
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nervous system
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• at E10.5, the choroid plexus of the fourth ventricle is hypoplastic
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hearing/vestibular/ear
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• significantly increased outer hair cell numbers relative to homozygotes or controls
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nervous system
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• significantly increased outer hair cell numbers relative to homozygotes or controls
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hearing/vestibular/ear
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• significantly increased inner hair cell numbers relative to homozygotes or controls
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nervous system
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• significantly increased inner hair cell numbers relative to homozygotes or controls
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nervous system
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• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5
• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated
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cellular
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• at E8.5 many differentiated neurons have already formed unlike in Hes1, Hes5 double mutants where premature differentiation is not seen until E9.5
• at E9.5 almost all cells are neurons in the ventral spinal cord and at E10.0 virtually all radial glial cells have differentiated
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mortality/aging
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• homozygous double mutants die by E11
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nervous system
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• at E9.5 and E10.5 radial glial cells prematurely differentiate into neurons resulting in failure of later born cells (oligodendrocytes, astrocytes, and ependymal cells) to be generated
• at E9.5 and E10.5 prematurely differentiated neurons are found in the regions where the optic vesicles should develop
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• neural tube defects in 71.2% of embryos
(J:62024)
• at E10.5 the cells of the neural tube are disorganized with many cells scattered across the lumen rather in contrast to the radial morphology seen in wild-type mice
(J:94391)
• also at E10.5 the outer boundary of the neural tube is irregular and ambiguous
(J:94391)
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• the forebrain monotonous tube
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• ependymal cells are absent
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• oligodendrocytes are absent
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• the ganglionic eminences are not properly formed due to premature neuronal differentiation
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• even greater neuron density in double homozygotes
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• neurons of the spinal cord and dorsal root ganglia are intermingled
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• the basal lamina is missing from the ventral spinal cord and neurons of the spinal cord and dorsal root ganglia are intermingled
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vision/eye
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• at E9.5 and E10.5 the optic vesicles are absent; instead, differentiated neurons are found in the region that would normally become the optic vesicle
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taste/olfaction
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• increased numbers of neurons in olfactory placodes at E10.5
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growth/size/body
embryo
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• neural tube defects in 71.2% of embryos
(J:62024)
• at E10.5 the cells of the neural tube are disorganized with many cells scattered across the lumen rather in contrast to the radial morphology seen in wild-type mice
(J:94391)
• also at E10.5 the outer boundary of the neural tube is irregular and ambiguous
(J:94391)
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respiratory system
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• increased numbers of neurons in olfactory placodes at E10.5
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craniofacial
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• increased numbers of neurons in olfactory placodes at E10.5
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cellular
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• at E9.5 and E10.5 radial glial cells prematurely differentiate into neurons resulting in failure of later born cells (oligodendrocytes, astrocytes, and ependymal cells) to be generated
• at E9.5 and E10.5 prematurely differentiated neurons are found in the regions where the optic vesicles should develop
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Analysis Tools