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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pik3r1tm1Dfr
targeted mutation 1, David A Fruman
MGI:2149438
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pik3r1tm1Dfr/Pik3r1tm1Dfr involves: 129S6/SvEvTac MGI:4940203
hm2
Pik3r1tm1Dfr/Pik3r1tm1Dfr involves: 129S6/SvEvTac * C57BL/6 MGI:2174983
cx3
Pik3r1tm1Dfr/Pik3r1tm1Dfr
Plcg2tm1Jni/Plcg2tm1Jni
involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:4940201


Genotype
MGI:4940203
hm1
Allelic
Composition
Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Dfr mutation (1 available); any Pik3r1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in fetal liver transplant assays into irradiated Jak3tm1Jni homozygotes, B cell differentiation is impeded at the T2 to follicular B cell transition and marginal zone B cell development is impaired compared to in control mice (J:104166)
• in fetal liver transplant assays into irradiated Jak3tm1Jni homozygotes, B cell differentiation is impeded at the T2 to follicular B cell transition and marginal zone B cell development is impaired compared to in control mice (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• markedly in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• markedly in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)

hematopoietic system
• in fetal liver transplant assays into irradiated Jak3tm1Jni homozygotes, B cell differentiation is impeded at the T2 to follicular B cell transition and marginal zone B cell development is impaired compared to in control mice (J:104166)
• in fetal liver transplant assays into irradiated Jak3tm1Jni homozygotes, B cell differentiation is impeded at the T2 to follicular B cell transition and marginal zone B cell development is impaired compared to in control mice (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• markedly in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)
• markedly in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes (J:104166)




Genotype
MGI:2174983
hm2
Allelic
Composition
Pik3r1tm1Dfr/Pik3r1tm1Dfr
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Dfr mutation (1 available); any Pik3r1 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 5% survive beyond 7 days of age (J:52229)
• less than 5% survive beyond 7 days of age (J:52229)

immune system
• development impaired at the pro-B cell stage (J:52229)
• development impaired at the pro-B cell stage (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced proliferative responses (J:52229)
• reduced proliferative responses (J:52229)

homeostasis/metabolism
• increased glucose tolerance in glucose tolerance tests (J:65523)
• increased glucose tolerance in glucose tolerance tests (J:65523)

cardiovascular system
• calcification of cardiac tissue (J:65523)
• calcification of cardiac tissue (J:65523)

liver/biliary system

muscle
• enlarged skeletal muscle fibers (J:65523)
• enlarged skeletal muscle fibers (J:65523)

adipose tissue
• brown fat necrosis (J:65523)
• brown fat necrosis (J:65523)

hematopoietic system
• development impaired at the pro-B cell stage (J:52229)
• development impaired at the pro-B cell stage (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced numbers of mature B cells (J:52229)
• reduced proliferative responses (J:52229)
• reduced proliferative responses (J:52229)

Mouse Models of Human Disease
OMIM ID Ref(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:52229 , J:65523




Genotype
MGI:4940201
cx3
Allelic
Composition
Pik3r1tm1Dfr/Pik3r1tm1Dfr
Plcg2tm1Jni/Plcg2tm1Jni
Genetic
Background
involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pik3r1tm1Dfr mutation (1 available); any Pik3r1 mutation (20 available)
Plcg2tm1Jni mutation (1 available); any Plcg2 mutation (13 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice die between E16 and E17 with the exception of one mouse which was runted and died within 1 day of birth (J:104166)
• mice die between E16 and E17 with the exception of one mouse which was runted and died within 1 day of birth (J:104166)

immune system
N
• T cell development is normal in fetal liver transplantation assays into irradiated Jak3tm1Jni homozygotes (J:104166)
• T cell development is normal in fetal liver transplantation assays into irradiated Jak3tm1Jni homozygotes (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, the pro- to pre-B cell transition is impeded compared to in control mice (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, the pro- to pre-B cell transition is impeded compared to in control mice (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, peripheral B cell development is blocked compared to in control mice (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, peripheral B cell development is blocked compared to in control mice (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)

growth/size/body
• single mouse born (J:104166)
• single mouse born (J:104166)

hematopoietic system
N
• hematopoiesis is normal (J:104166)
• hematopoiesis is normal (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, the pro- to pre-B cell transition is impeded compared to in control mice (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, the pro- to pre-B cell transition is impeded compared to in control mice (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, peripheral B cell development is blocked compared to in control mice (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, peripheral B cell development is blocked compared to in control mice (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes (J:104166)

cellular
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes (J:104166)





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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory