Mouse Genome Informatics
hm1
    Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes
• markedly in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes
• in fetal liver transplant assays into irradiated Jak3tm1Jni homozygotes, B cell differentiation is impeded at the T2 to follicular B cell transition and marginal zone B cell development is impaired compared to in control mice
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes

hematopoietic system
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes
• markedly in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes
• in fetal liver transplant assays into irradiated Jak3tm1Jni homozygotes, B cell differentiation is impeded at the T2 to follicular B cell transition and marginal zone B cell development is impaired compared to in control mice
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes
• slight in fetal liver transplant experiments into irradiated Jak3tm1Jnihomozygotes


Mouse Genome Informatics
hm2
    Pik3r1tm1Dfr/Pik3r1tm1Dfr
involves: 129S6/SvEvTac * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• less than 5% survive beyond 7 days of age

immune system
• reduced numbers of mature B cells
• reduced proliferative responses
• development impaired at the pro-B cell stage

homeostasis/metabolism
• increased glucose tolerance in glucose tolerance tests

cardiovascular system
• calcification of cardiac tissue

liver/biliary system

muscle
• enlarged skeletal muscle fibers

adipose tissue

hematopoietic system
• reduced numbers of mature B cells
• reduced proliferative responses
• development impaired at the pro-B cell stage

Mouse Models of Human Disease
OMIM IDRef(s)
Agammaglobulinemia, X-Linked; XLA 300755 J:52229 , J:65523


Mouse Genome Informatics
cx3
    Pik3r1tm1Dfr/Pik3r1tm1Dfr
Plcg2tm1Jni/Plcg2tm1Jni

involves: 129P2/OlaHsd * 129S6/SvEvTac
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice die between E16 and E17 with the exception of one mouse which was runted and died within 1 day of birth

immune system
N
• T cell development is normal in fetal liver transplantation assays into irradiated Jak3tm1Jni homozygotes (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, the pro- to pre-B cell transition is impeded compared to in control mice
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, peripheral B cell development is blocked compared to in control mice

growth/size
• single mouse born

hematopoietic system
N
• hematopoiesis is normal (J:104166)
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes
• dramatic in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, the pro- to pre-B cell transition is impeded compared to in control mice
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes
• in fetal liver transplant experiments into irradiated Jak3tm1Jni homozygotes, peripheral B cell development is blocked compared to in control mice

cellular
• in the bone marrow following fetal liver transplant into irradiated Jak3tm1Jni homozygotes