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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tnftm1Gkl
targeted mutation 1, George Kollias
MGI:2149024
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Tnftm1Gkl/Tnftm1Gkl B6;129S-Tnftm1Gkl/J MGI:4365459
hm2
Tnftm1Gkl/Tnftm1Gkl C.129S-Tnftm1Gkl MGI:4418571
hm3
Tnftm1Gkl/Tnftm1Gkl either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6) MGI:3582276
hm4
Tnftm1Gkl/Tnftm1Gkl involves: 129S/SvEv MGI:3527264
hm5
Tnftm1Gkl/Tnftm1Gkl involves: 129S/SvEv * C57BL/6 MGI:2175016
hm6
Tnftm1Gkl/Tnftm1Gkl involves: 129S/SvEv * C57BL/6J MGI:3722940
ht7
Tnftm1Gkl/Tnftm2Gkl involves: 129S/SvEv * C57BL/6 MGI:3622062
cn8
Faddtm1Mpa/Faddtm1Mpa
Tnftm1Gkl/Tnftm1Gkl
Tg(Vil-cre)997Gum/0
B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil-cre)997Gum MGI:5293404
cx9
Timp3tm1Rkho/Timp3tm1Rkho
Tnftm1Gkl/Tnftm1Gkl
involves: 129 * 129S/SvEv * C57BL/6 MGI:3664937
cx10
Krt8tm1Rgo/Krt8tm1Rgo
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N MGI:3711994
cx11
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tnftm1Gkl/Tnftm1Gkl
involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J MGI:3699099
cx12
Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl
involves: 129S/SvEv * C57BL/6 MGI:3053734
cx13
Tnftm1Gkl/Tnftm1Gkl
Zfp36tm1Pjb/Zfp36tm1Pjb
involves: 129S/SvEv * C57BL/6 MGI:5588803
cx14
Tnftm1Gkl/Tnftm1Gkl
Tnfaip3tm1Ama/Tnfaip3tm1Ama
involves: 129S/SvEv * C57BL/6J MGI:3055288


Genotype
MGI:4365459
hm1
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
B6;129S-Tnftm1Gkl/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 12 weeks of age, male homozygotes show a ~30% reduction in average testis weight relative to wild-type controls (J:143457)
• at 12 weeks of age, male homozygotes show a ~30% reduction in average testis weight relative to wild-type controls (J:143457)
• after puberty (P30 to adulthood), mRNA levels of key steroidogenesis-related genes are significantly lower in mutant testes than in wild-type testes (J:143457)
• after puberty (P30 to adulthood), mRNA levels of key steroidogenesis-related genes are significantly lower in mutant testes than in wild-type testes (J:143457)
• after puberty, male homozygotes display significantly lower testicular testosterone levels than wild-type males, as a result of higher anti-Mullerian hormone levels in mutant testes (J:143457)
• after puberty, male homozygotes display significantly lower testicular testosterone levels than wild-type males, as a result of higher anti-Mullerian hormone levels in mutant testes (J:143457)
• male homozygotes show a significant delay in the onset of spermatogenesis, likely due to decreased testicular testosterone levels (J:143457)
• at P26, the most advanced germ cells in mutant testes remain as late pachytene spermatocytes, instead of developing into haploid round spermatids as in wild-type testes (J:143457)
• at P33, only early elongated spermatids are noted in mutant testes, whereas late elongated spermatids are seen in wild-type testes (J:143457)
• male homozygotes show a significant delay in the onset of spermatogenesis, likely due to decreased testicular testosterone levels (J:143457)
• at P26, the most advanced germ cells in mutant testes remain as late pachytene spermatocytes, instead of developing into haploid round spermatids as in wild-type testes (J:143457)
• at P33, only early elongated spermatids are noted in mutant testes, whereas late elongated spermatids are seen in wild-type testes (J:143457)
• at 12 weeks of age, male homozygotes show a ~53% reduction in epididymal sperm count relative to wild-type controls (J:143457)
• in mutant males, the number of sperm per testis weight is only ~68% that of wild-type controls (J:143457)
• at 12 weeks of age, male homozygotes show a ~53% reduction in epididymal sperm count relative to wild-type controls (J:143457)
• in mutant males, the number of sperm per testis weight is only ~68% that of wild-type controls (J:143457)
• at P37, no sperm are yet detected in mutant epididymides (J:143457)
• at P56, spermatozoa are detected at the luminal edge of seminiferous epithelia in both wild-type and mutant testes; however, the lumen is only dilated in wild-type tubules indicating active release of sperm (J:143457)
• at P37, no sperm are yet detected in mutant epididymides (J:143457)
• at P56, spermatozoa are detected at the luminal edge of seminiferous epithelia in both wild-type and mutant testes; however, the lumen is only dilated in wild-type tubules indicating active release of sperm (J:143457)

endocrine/exocrine glands
• at 12 weeks of age, male homozygotes show a ~30% reduction in average testis weight relative to wild-type controls (J:143457)
• at 12 weeks of age, male homozygotes show a ~30% reduction in average testis weight relative to wild-type controls (J:143457)
• after puberty (P30 to adulthood), mRNA levels of key steroidogenesis-related genes are significantly lower in mutant testes than in wild-type testes (J:143457)
• after puberty (P30 to adulthood), mRNA levels of key steroidogenesis-related genes are significantly lower in mutant testes than in wild-type testes (J:143457)
• after puberty, male homozygotes display significantly lower testicular testosterone levels than wild-type males, as a result of higher anti-Mullerian hormone levels in mutant testes (J:143457)
• after puberty, male homozygotes display significantly lower testicular testosterone levels than wild-type males, as a result of higher anti-Mullerian hormone levels in mutant testes (J:143457)




Genotype
MGI:4418571
hm2
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
C.129S-Tnftm1Gkl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• DMBA and TPA-treated mice exhibit papillomas than in similarly treated wild-type mice (J:56068)
• DMBA and TPA-treated mice exhibit papillomas than in similarly treated wild-type mice (J:56068)

homeostasis/metabolism
• DMBA and TPA-treated mice exhibit papillomas than in similarly treated wild-type mice (J:56068)
• DMBA and TPA-treated mice exhibit papillomas than in similarly treated wild-type mice (J:56068)




Genotype
MGI:3582276
hm3
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
either: B6.129-Tnftm1Gkl or (involves: 129/Sv * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• a modest increase in peripheral white cell count is seen compared to wild-type mice (J:97783)
• a modest increase in peripheral white cell count is seen compared to wild-type mice (J:97783)
• neutrophil numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• neutrophil numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• lymphocyte numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• lymphocyte numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• Peyer's patches are fewer in number (J:97783)
• Peyer's patches are fewer in number (J:97783)
• homozygotes are protected from LPS/D-Gal induced shock (J:97783)
• homozygotes are protected from LPS/D-Gal induced shock (J:97783)
• homozygotes show increased sensitivity to systemic and alimentary L. monocytogenes infection (J:97783)
• homozygotes show increased sensitivity to systemic and alimentary L. monocytogenes infection (J:97783)

hematopoietic system
• a modest increase in peripheral white cell count is seen compared to wild-type mice (J:97783)
• a modest increase in peripheral white cell count is seen compared to wild-type mice (J:97783)
• neutrophil numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• neutrophil numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• lymphocyte numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)
• lymphocyte numbers are increased compared to Tnftm1.2Sned homozygotes (J:97783)




Genotype
MGI:3527264
hm4
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
involves: 129S/SvEv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• serum TNF levels were reduced in mutants injected with LPS and could not be detected on day 2 of Listeria monocytogenes infection (J:95684)
• serum TNF levels were reduced in mutants injected with LPS and could not be detected on day 2 of Listeria monocytogenes infection (J:95684)
• induction of MCP-1 was reduced in spleens of mutants infected with Listeria monocytogenes (J:95684)
• induction of MCP-1 was reduced in spleens of mutants infected with Listeria monocytogenes (J:95684)
• increased resistance to liver injury after ConA-induced autoimmune hepatitis, with only infiltrating cells but no liver necrosis detected (J:95684)
• increased resistance to liver injury after ConA-induced autoimmune hepatitis, with only infiltrating cells but no liver necrosis detected (J:95684)
• protected from S. aureus enterotoxin B induced toxic shock (J:95684)
• protected from S. aureus enterotoxin B induced toxic shock (J:95684)
• loss of resistance against Listeria monocytogenes infection (J:95684)
• loss of resistance against Listeria monocytogenes infection (J:95684)

homeostasis/metabolism
• serum TNF levels were reduced in mutants injected with LPS and could not be detected on day 2 of Listeria monocytogenes infection (J:95684)
• serum TNF levels were reduced in mutants injected with LPS and could not be detected on day 2 of Listeria monocytogenes infection (J:95684)




Genotype
MGI:2175016
hm5
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at 28 weeks, mutant animals weigh less (J:42579)
• at 28 weeks, mutant animals weigh less (J:42579)

adipose tissue

homeostasis/metabolism
• decreased plasma leptin concentrations at 28 weeks of age (J:42579)
• decreased plasma leptin concentrations at 28 weeks of age (J:42579)
• decreased fasting plasma glucose concentrations at 28 weeks of age (J:42579)
• decreased fasting plasma glucose concentrations at 28 weeks of age (J:42579)
• decreased plasma insulin concentrations at 28 weeks of age (J:42579)
• decreased plasma insulin concentrations at 28 weeks of age (J:42579)
• decreased plasma triglyceride concentrations at 28 weeks of age (J:42579)
• decreased plasma triglyceride concentrations at 28 weeks of age (J:42579)
• DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice however, malignant progression of tumors is normal (J:56068)
• however, malignant progression of tumors is normal (J:56068)
• DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice however, malignant progression of tumors is normal (J:56068)
• however, malignant progression of tumors is normal (J:56068)

immune system
N
• mutant spleen cells isolated 49 days after myelin oligodendrocyte glycoprotein (MOG) display lack of autoimmune T cell responses (proliferation) to MOG peptide, similar to wild-type spleen cells (J:114740)
• mutant spleen cells isolated 49 days after myelin oligodendrocyte glycoprotein (MOG) display lack of autoimmune T cell responses (proliferation) to MOG peptide, similar to wild-type spleen cells (J:114740)
• organized follicular dendritic cell networks are absent (J:42579)
• organized follicular dendritic cell networks are absent (J:42579)
• absence of splenic primary B cell follicles (J:47673)
• absence of splenic primary B cell follicles (J:47673)
• inability to form organized germinal centers (J:47673)
• inability to form organized germinal centers (J:47673)
• after immunization with sheep red blood cells (SRBCs), mutants fail to form organized germinal centers (J:114740)
• after immunization with sheep red blood cells (SRBCs), mutants fail to form organized germinal centers (J:114740)
• after intraperitoneal injection of SRBC, mutants exhibit severely impaired SRBC-specific IgG1 antibody responses (J:114740)
• after intraperitoneal injection of SRBC, mutants exhibit severely impaired SRBC-specific IgG1 antibody responses (J:114740)
• LPS-stimulated thioglycollate-elicited peritoneal macrophages (TEPMs) cannot induce thymocyte proliferation, but stimulated TEPMs in wild-type and Tnf homozygotes induce thymocyte proliferation with equal efficiency (J:114740)
• LPS-stimulated thioglycollate-elicited peritoneal macrophages (TEPMs) cannot induce thymocyte proliferation, but stimulated TEPMs in wild-type and Tnf homozygotes induce thymocyte proliferation with equal efficiency (J:114740)
• organized follicular dendritic cell networks are absent (J:40970)
• organized follicular dendritic cell networks are absent (J:40970)
• the typical subepithelial dome areas fail to form (J:40970)
• the typical subepithelial dome areas fail to form (J:40970)
• B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent (J:40970)
• B cells are present but no organized follicles are seen and organized follicular dendritic cell networks are absent (J:40970)
• average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice (J:40970)
• average of 2 - 4 per mouse compared to 6 - 8 in wild-type mice (J:40970)
• mesenteric lymph nodes (MLN) lack organized B cell follicles but occasionally have GC-like regions that are centered in B cell areas (J:114740)
• mesenteric lymph nodes (MLN) lack organized B cell follicles but occasionally have GC-like regions that are centered in B cell areas (J:114740)
• B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however, B cells are present and B and T cell areas are segregated (J:40970)
• B cell follicles and follicular dendritic cell network formation are impaired in mesenteric and peripheral lymph nodes; however, B cells are present and B and T cell areas are segregated (J:40970)
• 16 days post-immunization with pertussis toxin, mutants begin to show clinical signs of experimental allergic encephalomyelitis (EAE) which progresses to chronic non-remitting disease compared to wild-type mice which show signs of EAE at 12 days post-injectiona and peak EAE occurs at ~15 days, with gradual remission and results in only a mild deficit (J:114740)
• 16 days post-immunization with pertussis toxin, mutants begin to show clinical signs of experimental allergic encephalomyelitis (EAE) which progresses to chronic non-remitting disease compared to wild-type mice which show signs of EAE at 12 days post-injectiona and peak EAE occurs at ~15 days, with gradual remission and results in only a mild deficit (J:114740)
• when treated with D-gal (a hepatotoxin) at 20 mg/animal and doses of lipopolysaccharide (LPS) up to 100ug/25g body weight, mutants are completely resistant to LPS-induced death, but wild-type mice all die at 100-fold lower LPS doses (J:114740)
• when treated with D-gal (a hepatotoxin) at 20 mg/animal and doses of lipopolysaccharide (LPS) up to 100ug/25g body weight, mutants are completely resistant to LPS-induced death, but wild-type mice all die at 100-fold lower LPS doses (J:114740)
• in the skin following treatment with TPA compared with similarly treated wild-type mice (J:56068)
• in the skin following treatment with TPA compared with similarly treated wild-type mice (J:56068)
• impaired contact hypersensitivity response (J:47673)
• impaired contact hypersensitivity response (J:47673)
• susceptibility to death from Listeria monocytogenes infection (J:47673)
• susceptibility to death from Listeria monocytogenes infection (J:47673)
• with challenge at high doses (10000 cfu) of Listeria monocytogenes (LM), mutants show high sensitivity with maximal lethality at 6 days post-infection, compared to wild-type; mutants are highly sensitive when challenged with a physiological dose of LM (100 cfu) compared to wild-type (J:114740)
• with challenge at high doses (10000 cfu) of Listeria monocytogenes (LM), mutants show high sensitivity with maximal lethality at 6 days post-infection, compared to wild-type; mutants are highly sensitive when challenged with a physiological dose of LM (100 cfu) compared to wild-type (J:114740)

hematopoietic system
• organized follicular dendritic cell networks are absent (J:42579)
• organized follicular dendritic cell networks are absent (J:42579)
• absence of splenic primary B cell follicles (J:47673)
• absence of splenic primary B cell follicles (J:47673)
• inability to form organized germinal centers (J:47673)
• inability to form organized germinal centers (J:47673)
• after immunization with sheep red blood cells (SRBCs), mutants fail to form organized germinal centers (J:114740)
• after immunization with sheep red blood cells (SRBCs), mutants fail to form organized germinal centers (J:114740)
• after intraperitoneal injection of SRBC, mutants exhibit severely impaired SRBC-specific IgG1 antibody responses (J:114740)
• after intraperitoneal injection of SRBC, mutants exhibit severely impaired SRBC-specific IgG1 antibody responses (J:114740)
• LPS-stimulated thioglycollate-elicited peritoneal macrophages (TEPMs) cannot induce thymocyte proliferation, but stimulated TEPMs in wild-type and Tnf homozygotes induce thymocyte proliferation with equal efficiency (J:114740)
• LPS-stimulated thioglycollate-elicited peritoneal macrophages (TEPMs) cannot induce thymocyte proliferation, but stimulated TEPMs in wild-type and Tnf homozygotes induce thymocyte proliferation with equal efficiency (J:114740)

tumorigenesis
• DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice however, malignant progression of tumors is normal (J:56068)
• however, malignant progression of tumors is normal (J:56068)
• DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice DMBA and TPA-treated mice exhibit papillomas that develop with a greater latency than in similarly treated wild-type mice however, malignant progression of tumors is normal (J:56068)
• however, malignant progression of tumors is normal (J:56068)

craniofacial
• modest alveolar bone loss at 30 weeks (J:147935)
• modest alveolar bone loss at 30 weeks (J:147935)

skeleton
• modest alveolar bone loss at 30 weeks (J:147935)
• modest alveolar bone loss at 30 weeks (J:147935)
• significantly increased (J:135519)
• significantly increased (J:135519)
• 32% increase in trabecular bone volume (J:135519)
• 32% increase in trabecular bone volume (J:135519)

integument
• following DMBA and TPA treatment compared with similarly treated wild-type mice (J:56068)
• following DMBA and TPA treatment compared with similarly treated wild-type mice (J:56068)

cellular
• following DMBA and TPA treatment compared with similarly treated wild-type mice (J:56068)
• following DMBA and TPA treatment compared with similarly treated wild-type mice (J:56068)




Genotype
MGI:3722940
hm6
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• there are almost no metallophillic macrophages present in the marginal zone (J:124642)
• there are almost no metallophillic macrophages present in the marginal zone (J:124642)
• upon immunization with a T cell dependent antigen, there is a no formation of a follicular dendritic cell network (J:124642)
• upon immunization with a T cell dependent antigen, there is a no formation of a follicular dendritic cell network (J:124642)
• B cells fail to form a defined primary follicle instead forming a ring-like structure that is partially mixed with the T cell region (J:124642)
• B cells fail to form a defined primary follicle instead forming a ring-like structure that is partially mixed with the T cell region (J:124642)
• upon immunization with T cell dependent antigen, germinal centers fail to develop (J:124642)
• upon immunization with T cell dependent antigen, germinal centers fail to develop (J:124642)
• marginal sinus lining cells expressing mucosal addressin cell adhesion molecules are not present when immunized with a T cell antigen (J:124642)
• marginal sinus lining cells expressing mucosal addressin cell adhesion molecules are not present when immunized with a T cell antigen (J:124642)
• Peyer's patches have a flattened appearance (J:124642)
• Peyer's patches have a flattened appearance (J:124642)
• B cells fail to segregate from T cell areas (J:124642)
• B cells fail to segregate from T cell areas (J:124642)
• T cells fail to segregate from B cells (J:124642)
• T cells fail to segregate from B cells (J:124642)
• upon immunization with a T cell dependent antigen, germinal centers fail to develop (J:124642)
• upon immunization with a T cell dependent antigen, germinal centers fail to develop (J:124642)
• the mean number of Peyer's patches in mutant mice is 5 compared to 7 in wild-type mice (J:124642)
• the mean number of Peyer's patches in mutant mice is 5 compared to 7 in wild-type mice (J:124642)
• 7 days after a sublethal dose of Listeria monocytogenes, no mice survive compared to 60% survival of wild-type mice (J:124642)
• 7 days after a sublethal dose of Listeria monocytogenes, no mice survive compared to 60% survival of wild-type mice (J:124642)

hematopoietic system
• there are almost no metallophillic macrophages present in the marginal zone (J:124642)
• there are almost no metallophillic macrophages present in the marginal zone (J:124642)
• upon immunization with a T cell dependent antigen, there is a no formation of a follicular dendritic cell network (J:124642)
• upon immunization with a T cell dependent antigen, there is a no formation of a follicular dendritic cell network (J:124642)
• B cells fail to form a defined primary follicle instead forming a ring-like structure that is partially mixed with the T cell region (J:124642)
• B cells fail to form a defined primary follicle instead forming a ring-like structure that is partially mixed with the T cell region (J:124642)
• upon immunization with T cell dependent antigen, germinal centers fail to develop (J:124642)
• upon immunization with T cell dependent antigen, germinal centers fail to develop (J:124642)
• marginal sinus lining cells expressing mucosal addressin cell adhesion molecules are not present when immunized with a T cell antigen (J:124642)
• marginal sinus lining cells expressing mucosal addressin cell adhesion molecules are not present when immunized with a T cell antigen (J:124642)




Genotype
MGI:3622062
ht7
Allelic
Composition
Tnftm1Gkl/Tnftm2Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
Tnftm2Gkl mutation (1 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages (J:54056)
• spleen derived T lymphocytes have 3-fold greater TNF production and prolonged mRNA accumulation after incubation with an agonistic anti-CD3 antibody (J:54056)
• splenic B220+ cells also show increased basal and mitogen-stimulated TNF production (J:54056)
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls (J:54056)
• increased basal and LPS-induced secretion of TNF from thioglycollate-elicited peritoneal macrophages and bone marrow-derived macrophages (J:54056)
• spleen derived T lymphocytes have 3-fold greater TNF production and prolonged mRNA accumulation after incubation with an agonistic anti-CD3 antibody (J:54056)
• splenic B220+ cells also show increased basal and mitogen-stimulated TNF production (J:54056)
• primary synovial and lung fibroblasts display spontaneous TNF secretion and increased secretion following LPS stimulation unlike controls (J:54056)
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• increased sensitivity to LPS-induced mortality with 5 of 10 dying after injection of 100 ug/ 25 g compared to complete survival of control mice at the same dose (J:54056)
• increased sensitivity to LPS-induced mortality with 5 of 10 dying after injection of 100 ug/ 25 g compared to complete survival of control mice at the same dose (J:54056)

skeleton
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)
• disease onset occurs at 6-8 weeks of age (J:54056)
• early signs include hyperplasia of the synovial membrane and the presence of polymorphonuclear infiltrates; progressing to pannus and fibrous tissue formation, subchondral bone erosion, and articular cartilage destruction (J:54056)
• both IgM and IgG are detected in arthritic joints (J:54056)

homeostasis/metabolism
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)
• at 6 weeks of age circulating levels of TNF are up between 90 and 430 pg/ml compared to undetectable levels in wild-type mice (J:54056)

Mouse Models of Human Disease
OMIM ID Ref(s)
Rheumatoid Arthritis; RA 180300 J:54056




Genotype
MGI:5293404
cn8
Allelic
Composition
Faddtm1Mpa/Faddtm1Mpa
Tnftm1Gkl/Tnftm1Gkl
Tg(Vil-cre)997Gum/0
Genetic
Background
B6.Cg-Faddtm1Mpa Tnftm1Gkl Tg(Vil-cre)997Gum
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Faddtm1Mpa mutation (0 available); any Fadd mutation (4 available)
Tg(Vil-cre)997Gum mutation (2 available)
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• reduced numbers (J:175865)
• reduced numbers (J:175865)
• less severe than in Faddtm1Mpa/Faddtm1Mpa Tg(Vil-cre)997Gum mice (J:175865)
• less severe than in Faddtm1Mpa/Faddtm1Mpa Tg(Vil-cre)997Gum mice (J:175865)

endocrine/exocrine glands
• reduced numbers (J:175865)
• reduced numbers (J:175865)

immune system
• less severe than in Faddtm1Mpa/Faddtm1Mpa Tg(Vil-cre)997Gum mice (J:175865)
• less severe than in Faddtm1Mpa/Faddtm1Mpa Tg(Vil-cre)997Gum mice (J:175865)




Genotype
MGI:3664937
cx9
Allelic
Composition
Timp3tm1Rkho/Timp3tm1Rkho
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
involves: 129 * 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Timp3tm1Rkho mutation (0 available); any Timp3 mutation (5 available)
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• double mutants subjected to cardiac pressure overload show a greater increase in left ventricle dilation after 3 weeks than wildtype but less than seen in single Timp3 homozygous mutants (J:112033)
• double mutants subjected to cardiac pressure overload show a greater increase in left ventricle dilation after 3 weeks than wildtype but less than seen in single Timp3 homozygous mutants (J:112033)
• double mutants subjected to cardiac pressure overload show a greater decline in cardiac contractility than wild-type but not as much as single Timp3 homozygous mutants (J:112033)
• double mutants subjected to cardiac pressure overload show a greater decline in cardiac contractility than wild-type but not as much as single Timp3 homozygous mutants (J:112033)

hematopoietic system
• myocardium of double mutants subjected to cardiac pressure overload contains significantly higher numbers of neutrophils scattered throughout the left ventricle compared with single homozygous Timp3 mutants or wild-type (J:112033)
• myocardium of double mutants subjected to cardiac pressure overload contains significantly higher numbers of neutrophils scattered throughout the left ventricle compared with single homozygous Timp3 mutants or wild-type (J:112033)

immune system
• myocardium of double mutants subjected to cardiac pressure overload contains significantly higher numbers of neutrophils scattered throughout the left ventricle compared with single homozygous Timp3 mutants or wild-type (J:112033)
• myocardium of double mutants subjected to cardiac pressure overload contains significantly higher numbers of neutrophils scattered throughout the left ventricle compared with single homozygous Timp3 mutants or wild-type (J:112033)

muscle
• double mutants subjected to cardiac pressure overload show a greater decline in cardiac contractility than wild-type but not as much as single Timp3 homozygous mutants (J:112033)
• double mutants subjected to cardiac pressure overload show a greater decline in cardiac contractility than wild-type but not as much as single Timp3 homozygous mutants (J:112033)




Genotype
MGI:3711994
cx10
Allelic
Composition
Krt8tm1Rgo/Krt8tm1Rgo
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krt8tm1Rgo mutation (1 available); any Krt8 mutation (8 available)
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• about 60% survive beyond 250 days (J:121811)
• about 60% survive beyond 250 days (J:121811)
• Background Sensitivity: about 50% survive to birth as opposed to 25% when maternal TNF is produced (J:121811)
• Background Sensitivity: about 50% survive to birth as opposed to 25% when maternal TNF is produced (J:121811)




Genotype
MGI:3699099
cx11
Allelic
Composition
Sh3bp2tm1Bjro/Sh3bp2tm1Bjro
Tnftm1Gkl/Tnftm1Gkl
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sh3bp2tm1Bjro mutation (0 available); any Sh3bp2 mutation (3 available)
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
N
• unlike in mice homozygous for the Sh3bp2 allele alone, trabecular and cortical bone loss are not seen (J:117880)
• unlike in mice homozygous for the Sh3bp2 allele alone, trabecular and cortical bone loss are not seen (J:117880)
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)

immune system
N
• unlike in mice homozygous for the Sh3bp2 allele alone, lymph node abnormalities and systemic inflammation are not seen (J:117880)
• unlike in mice homozygous for the Sh3bp2 allele alone, lymph node abnormalities and systemic inflammation are not seen (J:117880)
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)

hematopoietic system
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)

cellular
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)
• bone marrow displays enhanced production of osteoclasts in response to cytokine stimulation, similar to mice homozygous for the Sh3bp2 allele alone (J:117880)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Cherubism 118400 J:117880




Genotype
MGI:3053734
cx12
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Tnfrsf1atm1Gkl/Tnfrsf1atm1Gkl
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfrsf1atm1Gkl mutation (1 available); any Tnfrsf1a mutation (22 available)
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
N
• no liver inflammation is seen unlike in Tnfrsf1atm1Gkl homozygotes (J:92470)
• no liver inflammation is seen unlike in Tnfrsf1atm1Gkl homozygotes (J:92470)




Genotype
MGI:5588803
cx13
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Zfp36tm1Pjb/Zfp36tm1Pjb
Genetic
Background
involves: 129S/SvEv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
Zfp36tm1Pjb mutation (0 available); any Zfp36 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice do not show improvement of the endothelial dysfunction seen in single Zfp36 homozygotes, with aortas still less responsive to acetylcholine-induced relaxation (J:214114)
• mice do not show improvement of the endothelial dysfunction seen in single Zfp36 homozygotes, with aortas still less responsive to acetylcholine-induced relaxation (J:214114)

cellular
• mice show a partial reduction of the enhanced reactive oxygen and nitrogen species (RONS) formation under PDBu-stimulated conditions in whole blood that is seen in single Zfp36 homozygotes (J:214114)
• mice show a partial reduction of the enhanced reactive oxygen and nitrogen species (RONS) formation under PDBu-stimulated conditions in whole blood that is seen in single Zfp36 homozygotes (J:214114)

muscle
• mice do not show improvement of the endothelial dysfunction seen in single Zfp36 homozygotes, with aortas still less responsive to acetylcholine-induced relaxation (J:214114)
• mice do not show improvement of the endothelial dysfunction seen in single Zfp36 homozygotes, with aortas still less responsive to acetylcholine-induced relaxation (J:214114)




Genotype
MGI:3055288
cx14
Allelic
Composition
Tnftm1Gkl/Tnftm1Gkl
Tnfaip3tm1Ama/Tnfaip3tm1Ama
Genetic
Background
involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tnfaip3tm1Ama mutation (0 available); any Tnfaip3 mutation (2 available)
Tnftm1Gkl mutation (5 available); any Tnf mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

growth/size/body

immune system
• bone marrow derived macrophages produce more IL-6 and nitric oxide in response to LPS treatment compared to Tnfaip1tm1Ama heterozygous Tnftm1Gkl homozygous macrophages (J:92694)
• bone marrow derived macrophages produce more IL-6 and nitric oxide in response to LPS treatment compared to Tnfaip1tm1Ama heterozygous Tnftm1Gkl homozygous macrophages (J:92694)
• the absolute number and percentage of myeloid cells is increased in multiple tissues (J:92694)
• the absolute number and percentage of myeloid cells is increased in multiple tissues (J:92694)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory