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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Insl3tm1Par
targeted mutation 1, Luis F Parada
MGI:2148889
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Insl3tm1Par/Insl3tm1Par involves: 129/Sv * CD-1 MGI:2661963
ht2
Insl3tm1Par/Insl3+ involves: 129/Sv * CD-1 MGI:2661992


Genotype
MGI:2661963
hm1
Allelic
Composition
Insl3tm1Par/Insl3tm1Par
Genetic
Background
involves: 129/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insl3tm1Par mutation (0 available); any Insl3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

reproductive system
• absence of spermatids and mature sperm
• males exhibit thin gubernacular bulbs and cords which collectively resemble the wild-type female gubernaculum
• testes were of normal size at birth but progressively degenerated
• however, prostate gland morphology, seminal gland morphology, and serum testosterone levels are normal
• bilateral cryptorchism with testes resting adjacent to the lower pole of the kidneys
• the right testicle of some males was in the contralateral position
• vas deferens were elongated
• prolonged cycle with each phase extended
• most females had cycles exceeding 20 days
• 22% of females were infertile, however ovarian and uterine morphology was normal
• fertile females gave birth to fewer litters
• litters were of normal size

behavior/neurological
N
• normal mounting and copulatory behavior

endocrine/exocrine glands
• testes were of normal size at birth but progressively degenerated
• however, prostate gland morphology, seminal gland morphology, and serum testosterone levels are normal
• bilateral cryptorchism with testes resting adjacent to the lower pole of the kidneys
• the right testicle of some males was in the contralateral position

skeleton
• males exhibit thin gubernacular bulbs and cords which collectively resemble the wild-type female gubernaculum

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cryptorchidism DOID:11383 OMIM:219050
J:55881




Genotype
MGI:2661992
ht2
Allelic
Composition
Insl3tm1Par/Insl3+
Genetic
Background
involves: 129/Sv * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Insl3tm1Par mutation (0 available); any Insl3 mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands
• 75% of neonatal males had partial unilateral cryptorchism
• 25% of neonatal males had partial bilateral cryptorchism
• all adult males had fully descended testes
• 25% of neonatal males had partial bilateral cryptorchism
• 75% of neonatal males had partial unilateral cryptorchism

reproductive system
• 75% of neonatal males had partial unilateral cryptorchism
• 25% of neonatal males had partial bilateral cryptorchism
• all adult males had fully descended testes
• 25% of neonatal males had partial bilateral cryptorchism
• 75% of neonatal males had partial unilateral cryptorchism
• delayed gubernacular regression

skeleton
• delayed gubernacular regression

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
cryptorchidism DOID:11383 OMIM:219050
J:55881





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory