About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ctnnb1tm2.1Kem
targeted mutation 2.1 Rolf Kemler
MGI:2148569
Summary 22 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ctnnb1tm2.1Kem/Ctnnb1tm2.1Kem involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6 MGI:2674117
cn2
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:5440185
cn3
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 MGI:5440184
cn4
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA MGI:5440178
cn5
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA MGI:5440177
cn6
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Cdx1-cre)23Kem/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB MGI:5440180
cn7
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Cdx1-cre)23Kem/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB MGI:5440181
cn8
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Zp3-cre)93Knw/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:5440176
cn9
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Zp3-cre)93Knw/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J MGI:5440179
cn10
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J MGI:5440182
cn11
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J MGI:5440183
cn12
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ MGI:5006680
cn13
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Kdrtm1(cre)Sato/Kdr+
involves: 129S1/Sv * 129X1/SvJ MGI:3831190
cn14
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Foxn1-cre)1Tbo/0
involves: 129S1/Sv * 129X1/SvJ MGI:5440186
cn15
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6 MGI:5509195
cn16
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre/ERT2)1Lwd/0
involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr MGI:5509196
cn17
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Tek-cre)1Ywa/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:3710231
cn18
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Corintm2(cre)Bamo/Corin+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:4844104
cn19
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
H2az2Tg(Wnt1-cre)11Rth/?
involves: 129/Sv * C57BL/6 * CBA MGI:2674120
cx20
Ctnnb1tm2.1Kem/Ctnnb1+
Sall4Gt(W097E01)Flo/Sall4+
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6 MGI:3809920
cx21
Axin1tm4Cos/Axin1tm4Cos
Ctnnb1tm2.1Kem/Ctnnb1+
involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:3840269
cx22
Ctnnb1tm2.1Kem/Ctnnb1+
Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
involves: 129/Sv * C57BL/6 * CBA MGI:3612484


Genotype
MGI:2674117
hm1
Allelic
Composition
Ctnnb1tm2.1Kem/Ctnnb1tm2.1Kem
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• homozygotes died at gastrulation

embryo
• cell adhesion defect




Genotype
MGI:5440185
cn2
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Foxn1-cre)1Tbo/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Tg(Foxn1-cre)1Tbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sortm1(Ctnnb1)Kem
• broad stripes of hair loss are seen
• loss is followed by regrowth

growth/size/body
• at P14; however, mice catch up with littermate controls with age




Genotype
MGI:5440184
cn3
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Foxn1-cre)1Tbo/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Tg(Foxn1-cre)1Tbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
N
• skin lesions are not seen unlike in mutant mice lacking Gt(ROSA)26Sortm1(Ctnnb1)Kem
• thinner but continuous coat

growth/size/body
• at P14; however, mice catch up with littermate controls with age




Genotype
MGI:5440178
cn4
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Edil3Tg(Sox2-cre)1Amc mutation (4 available); any Edil3 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• absence of embryonic structures at E8.5




Genotype
MGI:5440177
cn5
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1.1(Ctnnb1)Kem
Edil3Tg(Sox2-cre)1Amc/Edil3+
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Edil3Tg(Sox2-cre)1Amc mutation (4 available); any Edil3 mutation (4 available)
Gt(ROSA)26Sortm1.1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium
• expression analysis indicates failure to gastrulate
• formation of proper embryonic structures is incomplete




Genotype
MGI:5440180
cn6
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Cdx1-cre)23Kem/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Tg(Cdx1-cre)23Kem mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E14.5 embryos consist of a head attached to internal organs including lung, liver and intestine while the urogenital system and mesoderm-derived tissues making up the body wall are highly underdeveloped or absent
• truncated tail bud region at E9.5

limbs/digits/tail
• truncated tail bud region at E9.5




Genotype
MGI:5440181
cn7
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
Tg(Cdx1-cre)23Kem/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Tg(Cdx1-cre)23Kem mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• develop until birth but do not survive

embryo
N
• at E9.5 the length of tail buds are similar to controls
• abnormally folded distally at E9.5

renal/urinary system
• at E14.5
• at E14.5

reproductive system
• at E14.5
• small gonads at E14.5

limbs/digits/tail
• deformed shortened forelimb digits vertebrae at E18.5
• at E18.5
• at E18.5
• at E18.5 in rare cases some rudimentary upper hindlimb bones are present
• at E14.5
• at E14.5

skeleton
• at E18.5
• deformed shortened fused ribs at E18.5
• at E18.5
• at E18.5
• deformed shortened fused vertebrae at E18.5
• at E18.5
• at E18.5

digestive/alimentary system
• at E14.5

nervous system
• abnormally folded distally at E9.5

endocrine/exocrine glands
• small gonads at E14.5




Genotype
MGI:5440176
cn8
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
Tg(Zp3-cre)93Knw/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
Tg(Zp3-cre)93Knw mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• at E8.5 embryos have a sac-like structure composed of 2 layers where the outer layer is reminiscent of the visceral endoderm and the inner layer has characteristics of a pseudostratified epithelium
• expression analysis indicates failure to gastrulate
• formation of proper embryonic structures is incomplete




Genotype
MGI:5440179
cn9
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Zp3-cre)93Knw/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Tg(Zp3-cre)93Knw mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

embryo
• absence of embryonic structures at E8.5




Genotype
MGI:5440182
cn10
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sortm1(Ctnnb1)Kem
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within hours of birth probably because of an inability to feed




Genotype
MGI:5440183
cn11
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Gt(ROSA)26Sortm1(Ctnnb1)Kem/Gt(ROSA)26Sor+
H2az2Tg(Wnt1-cre)11Rth/0
Genetic
Background
involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(Ctnnb1)Kem mutation (0 available); any Gt(ROSA)26Sor mutation (523 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
• brain defects

craniofacial
• impaired morphogenesis of craniofacial structures




Genotype
MGI:5006680
cn12
Allelic
Composition
Amhr2tm3(cre)Bhr/Amhr2+
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Genetic
Background
involves: 129S1/Sv * 129S7/SvEvBrd * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Amhr2tm3(cre)Bhr mutation (1 available); any Amhr2 mutation (23 available)
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• newborn males have both male and female reproductive tracts

embryo
• mesenchyme is less condensed
• decrease in apoptosis in the epithelium




Genotype
MGI:3831190
cn13
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Kdrtm1(cre)Sato/Kdr+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Kdrtm1(cre)Sato mutation (1 available); any Kdr mutation (10 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• all embryos die by E12.5 due to severe hemorrhaging within the central nervous system

cardiovascular system
• in E12.5 embryos, endothelial cells and pericytes are entirely absent from the neuroepithelium
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos

nervous system
• hemorrhaging is detected throughout the developing brain of E12.5 embryos
• hemorrhaging is detected throughout the developing spine of E12.5 embryos
• hemorrhaging and downregulation of the endothelial marker GLUT-1 suggest a defect in the blood brain barrier of developing embryos




Genotype
MGI:5440186
cn14
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Foxn1-cre)1Tbo/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Tg(Foxn1-cre)1Tbo mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

integument




Genotype
MGI:5509195
cn15
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Tg(T-cre)1Lwd mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• severely truncated at E8.5
• at E8.5, somites are disorganized




Genotype
MGI:5509196
cn16
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(T-cre/ERT2)1Lwd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C3H/HeNcr * C57BL/6NCr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Tg(T-cre/ERT2)1Lwd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• with tamoxifen administration at E6.5, E8.5 embryos phenocopy the caudal body truncation seen with constitutive T-cre mediated inactivation
• with tamoxifen administration at E8.5, E10.5 embryos show defects in depletion of pre-somitic mesoderm (PSM) and segmentation defects, similar to embryos at E8.5
• with tamoxifen administration at E6.5 or E8.5, E8.5 and E10.5 embryos show disruption of somite patterning




Genotype
MGI:3710231
cn17
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Tg(Tek-cre)1Ywa/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Tg(Tek-cre)1Ywa mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% die by E11.5 and 100% die by E13.5

cardiovascular system
• in the head, the vascular network is less organized, with vessels of irregular diameter and shape and often blind ending vessels and lacunae-like bifurcations are observed
• cephalic vessels show an inconstant diameter and often form acute turns and branching
• endocardial and vascular endothelial cells are more elongated, resulting in a continuously thinner endothelial layer
• endothelial cells present a higher degree of fenestration; these structures are discontinuities in the cell membranes
• endothelial cells have altered intercellular junctional organization, with thinner and longer bundles of actin filaments
• the labyrinthine layer is less vascularized, there is a reduction in the number of fetal blood vessels that penetrate into the labyrinthine area and they remain concentrated in the chorionic plate
• vitelline vessels have a smaller diameter
• however, the primary vascular plexus is present and correctly organized
• thin endocardium
• frequently have extensive liquid accumulation in the pericardial cavity
• about 50% of embryos have hemorrhages in different vascular areas such as the head and the dorsal vessels

embryo
• vitelline vessels have a smaller diameter
• however, the primary vascular plexus is present and correctly organized
• the labyrinthine layer is less vascularized, there is a reduction in the number of fetal blood vessels that penetrate into the labyrinthine area and they remain concentrated in the chorionic plate
• reduced in thickness
• umbilical vessels are often increased in number, have a smaller diameter and are abnormally branched or anastomosed
• seen at E10.5 but not E8.5

homeostasis/metabolism
• frequently have extensive liquid accumulation in the pericardial cavity




Genotype
MGI:4844104
cn18
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
Corintm2(cre)Bamo/Corin+
Gt(ROSA)26Sortm1(EYFP)Cos/Gt(ROSA)26Sor+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Corintm2(cre)Bamo mutation (0 available); any Corin mutation (3 available)
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
Gt(ROSA)26Sortm1(EYFP)Cos mutation (6 available); any Gt(ROSA)26Sor mutation (523 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
integument
• auchene growth is terminated before formation of the single bend unlike in wild-type mice
• however, the first segment is normal
• shorter, thinner, and more numerous than in wild-type mice
• at the end of the first hair cycle, all hairs are shorter and thinner than in wild-type mice
• the first segment of zigzag hairs is variable in length from 60% to 100% of wild-type hair length
• the second segment is reduced in length 50% to 60% compared to in wild-type mice
• the first and second segments are thinner than in wild-type mice
• zigzag hairs lack the third and fourth segment unlike in wild-type mice
• duration of anagen is decreased compared to in wild-type mice
• hair follicles enter catagen prematurely compared to in wild-type mice
• catagen onset occurs at P12 and is less synchronized than in wild-type mice
• telogen begins earlier than in wild-type mice
• 40 days after depilation, only sparse hair regenerate unlike in similarly treated wild-type mice
• proliferation of matrix progenitor cells abutting the dermal papilla (MPADs) and their progeny is reduced compared to in wild-type mice
• mice fail to exhibit normal hair follicle regeneration compared with wild-type mice
• the number of apoptotic cells averaged over all follicles is increased

cellular
• the number of apoptotic cells averaged over all follicles is increased




Genotype
MGI:2674120
cn19
Allelic
Composition
Ctnnb1tm2Kem/Ctnnb1tm2.1Kem
H2az2Tg(Wnt1-cre)11Rth/?
Genetic
Background
involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Ctnnb1tm2Kem mutation (1 available); any Ctnnb1 mutation (22 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mutant mice are born

craniofacial
• craniofacial bones derived from neural crest cells are absent
• bones present include optic vesicle, basioccipital, exoccipital

skeleton
• craniofacial bones derived from neural crest cells are absent
• bones present include optic vesicle, basioccipital, exoccipital

nervous system
• shortened neural tube
• brain morphogenesis grossly abnormal between E10.5 and 18.5
• isthmic border between midbrain and rhombencephalon not visible
• choroid plexus absent by E12.5
• by E10.5 parts of the midbrain are missing
• no discernable midbrain by E12.5
• enlarged telencephalon
• walls of cephalic vesicles thinner
• anterior hindbrain is missing by E10.5
• poorly formed connections between cranial ganglia and hindbrain
• cerebellum is missing at E12.5
• anterior hindbrain is missing by E10.5
• combined ganglion with vestibulocochlear nerve abnormal
• roots poorly formed
• hypoglossal nerve missing
• roots poorly formed
• first spinal root ganglion missing
• other spinal root ganglia severely affected as well

embryo
• shortened neural tube




Genotype
MGI:3809920
cx20
Allelic
Composition
Ctnnb1tm2.1Kem/Ctnnb1+
Sall4Gt(W097E01)Flo/Sall4+
Genetic
Background
involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Sall4Gt(W097E01)Flo mutation (0 available); any Sall4 mutation (95 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• absent at weaning possibly indicating embryonic lethality

embryo
• expression analysis indicates impaired mesoderm development
• a gap in T expression is seen in the anterior primitive streak between E7.5 and E7.75 in the area where cells fate mapped to give rise to paraxial mesoderm are found

growth/size/body




Genotype
MGI:3840269
cx21
Allelic
Composition
Axin1tm4Cos/Axin1tm4Cos
Ctnnb1tm2.1Kem/Ctnnb1+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Axin1tm4Cos mutation (0 available); any Axin1 mutation (3 available)
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike Axin1tm4Cos homozygotes, mice survive until E18.5 when they are sacrificed

craniofacial
• mice lack nasal structures unlike wild-type mice

respiratory system
• mice lack nasal structures unlike wild-type mice

nervous system
• mice have multiple brain malformations unlike wild-type mice

digestive/alimentary system

growth/size/body
• mice lack nasal structures unlike wild-type mice




Genotype
MGI:3612484
cx22
Allelic
Composition
Ctnnb1tm2.1Kem/Ctnnb1+
Otx2tm1(Dkk1)Imat/Otx2tm1(Dkk1)Imat
Genetic
Background
involves: 129/Sv * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm2.1Kem mutation (0 available); any Ctnnb1 mutation (22 available)
Otx2tm1(Dkk1)Imat mutation (0 available); any Otx2 mutation (36 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
embryo
• based on expression of anterior visceral endoderm markers, the anterior migration defects of distal visceral endoderm cells observed in 6.5 p.d.c. Otx2tm2/Otx2tm2 embryo was partially rescued





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/24/2020
MGI 6.15
The Jackson Laboratory