Phenotypes associated with this allele

• Allele Symbol: Mme^tm1Cge
• Allele Name: targeted mutation 1, Craig Gerard
• Allele ID: MGI:2137696
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mme^tm1Cge/Mme^tm1Cge	B6.129S4-Mme^tm1Cge	MGI:3577844
hm2	Mme^tm1Cge/Mme^tm1Cge	involves: 129S4/SvJae * C57BL/6	MGI:3577843

Genotype
MGI:3577844

hm1

• Allelic Composition: Mme^tm1Cge/Mme^tm1Cge
• Genetic Background: B6.129S4-Mme^tm1Cge

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased susceptibility to type I hypersensitivity reaction ( J:66854 )

• allergic contact dermatitis

dermatitis ( J:66854 )

• increased allergic contact dermatitis, 80-120% higher than controls

homeostasis/metabolism

skin edema ( J:66854 )

• significant edema seen in sensitized animals after challenge

• increased inflammatory infiltrate, primarily of neutrophile and mononuclear cells

• epidermal hyperplasia between 16 and 72 hours after antigen challenge

integument

skin edema ( J:66854 )

• significant edema seen in sensitized animals after challenge

• increased inflammatory infiltrate, primarily of neutrophile and mononuclear cells

• epidermal hyperplasia between 16 and 72 hours after antigen challenge

dermatitis ( J:66854 )

• increased allergic contact dermatitis, 80-120% higher than controls

Genotype
MGI:3577843

hm2

• Allelic Composition: Mme^tm1Cge/Mme^tm1Cge
• Genetic Background: involves: 129S4/SvJae * C57BL/6

liver/biliary system

diffuse hepatic necrosis ( J:70516 )

• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b

nervous system

abnormal axon morphology ( J:244998 )

• myelinated fibers of femoral quadriceps nerves and cutaneous saphenous nerves appear more densely packed with smaller extracellular spaces

• however, femoral quadriceps nerves and cutaneous saphenous nerves of 13-14 month old mice appear grossly normal, with normal myelinated nerve fiber density and nerve fiber size distribution

• axons of Remak fibers are usually separated by Schwann cell process in wild-type mice, however such separating Schwann cell protrusions are rare in mutants and axons often show direct contacts with neighboring axons indicating ensheathment of Remak bundles

abnormal internode morphology ( J:244998 )

• smaller internodal, non-compact myelin domains, like Schmidt-Lantermann incisures, are seen

increased myelin sheath thickness ( J:244998 )

• thick myelin sheaths, particularly of large and medium-sized caliber axons

• however, degenerative features such as onion bulb cells, denervated Schwann cells, and myelin degeneration are not seen and nerve conduction studies show no differences from wild-type mice

homeostasis/metabolism

amyloidosis ( J:104962 )

• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age

abnormal circulating protein level ( J:104962 )

• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls

cellular

diffuse hepatic necrosis ( J:70516 )

• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b

behavior/neurological

behavior/neurological phenotype ( J:244998 )

N • mice do not show obvious abnormalities in motor performance or coordination

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:69830