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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Mmetm1Cge
targeted mutation 1, Craig Gerard
MGI:2137696
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Mmetm1Cge/Mmetm1Cge B6.129S4-Mmetm1Cge MGI:3577844
hm2
Mmetm1Cge/Mmetm1Cge involves: 129S4/SvJae * C57BL/6 MGI:3577843


Genotype
MGI:3577844
hm1
Allelic
Composition
Mmetm1Cge/Mmetm1Cge
Genetic
Background
B6.129S4-Mmetm1Cge
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmetm1Cge mutation (0 available); any Mme mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• increased allergic contact dermatitis, 80-120% higher than controls

homeostasis/metabolism
• significant edema seen in sensitized animals after challenge
• increased inflammatory infiltrate, primarily of neutrophile and mononuclear cells
• epidermal hyperplasia between 16 and 72 hours after antigen challenge

integument
• significant edema seen in sensitized animals after challenge
• increased inflammatory infiltrate, primarily of neutrophile and mononuclear cells
• epidermal hyperplasia between 16 and 72 hours after antigen challenge
• increased allergic contact dermatitis, 80-120% higher than controls




Genotype
MGI:3577843
hm2
Allelic
Composition
Mmetm1Cge/Mmetm1Cge
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mmetm1Cge mutation (0 available); any Mme mutation (29 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b

homeostasis/metabolism
• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls
• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:69830





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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory