Mouse Genome Informatics
hm1
    Mmetm1Cge/Mmetm1Cge
B6.129S4-Mmetm1Cge
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• increased allergic contact dermatitis, 80-120% higher than controls

homeostasis/metabolism
• significant edema seen in sensitized animals after challenge
• increased inflammatory infiltrate, primarily of neutrophile and mononuclear cells
• epidermal hyperplasia between 16 and 72 hours after antigen challenge

integument
• significant edema seen in sensitized animals after challenge
• increased inflammatory infiltrate, primarily of neutrophile and mononuclear cells
• epidermal hyperplasia between 16 and 72 hours after antigen challenge
• increased allergic contact dermatitis, 80-120% higher than controls


Mouse Genome Informatics
hm2
    Mmetm1Cge/Mmetm1Cge
involves: 129S4/SvJae * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
liver/biliary system
• diffuse hemorrhagic necrosis at death after treatment with combined endotoxin lipopolysaccharide and D-galactosamine or the combination of TNFalpha and Il1b

homeostasis/metabolism
• mice have elevated plasma levels of amyloid beta 42 and 40 relative to controls

other phenotype
• amyloid beta40 and 42 protein levels are elevated in mutant vs controls at 3-6 and at 11 months of age

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:69830