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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dvl1tm1Awb
targeted mutation 1, Anthony Wynshaw-Boris
MGI:2137230
Summary 14 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Dvl1tm1Awb/Dvl1tm1Awb involves: 129S6/SvEvTac MGI:2654530
cx2
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss) MGI:2654558
cx3
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2+
involves: 129S6/SvEvTac MGI:3608684
cx4
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
involves: 129S6/SvEvTac MGI:3715978
cx5
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)3Awb/?
involves: 129S6/SvEvTac MGI:3715991
cx6
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)4Awb/?
involves: 129S6/SvEvTac MGI:3715992
cx7
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*K446M/EGFP)5Awb/?
involves: 129S6/SvEvTac MGI:3715993
cx8
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)1Awb/?
involves: 129S6/SvEvTac MGI:3715988
cx9
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
involves: 129S6/SvEvTac MGI:3715989
cx10
Dvl1tm1Awb/Dvl1tm1Awb
Dvl3tm1Awb/Dvl3tm1Awb
involves: 129S6/SvEvTac * Black Swiss MGI:3831928
cx11
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
involves: 129S6/SvEvTac * C57BL/6 MGI:3715980
cx12
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715984
cx13
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2Lp
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715987
cx14
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
involves: 129S6/SvEvTac * LPT/LeJ MGI:3715981


Genotype
MGI:2654530
hm1
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• homozygotes are viable, fertile and display no motor deficits or differences in pain sensitivity relative to wild-type mice
• no significant differences in spatial learning and memory are observed
• homozygotes do not trim/barber their cagemates' whiskers or facial hair, unlike the majority of separately housed wild-type littermates which lack whiskers and have trimmed facial hair
• when housed separately as uniform genotypes, all post-weaning homozygotes between 2 and 9 months of age display full sets of whiskers and facial hair, relative to only 25%-50% of age-matched wild-type controls
• when housed with wild-type mice, homozygotes lose all whiskers and facial hair in 5 of 11 cages after mixed housing and regrow their whiskers within 2 weeks after returning to their home cage; in contrast, whiskerless wild-type mice consistently regrow full sets of whiskers and facial hair within 2-4 weeks after mixed genotype housing and have their whiskers trimmed within 2 weeks of return to their home cage
• homozygotes display attenuated responses to acoustic startle stimuli relative to wild-type mice
• in contrast, tactile startle reponses remain unaffected
• when housed separately as uniform genotypes, homozygotes display only 2 episodes of social behaviors whereas wild-type mice display 44 episodes including social grooming, mounting, tail pulling and sniffing; however, the frequency of self-grooming is not significantly different between wild-type and mutant mice (41 vs 36 episodes, respectively)
• when paired against each other in the social dominance tube test, homozygotes display a significantly lower percentage of wins than sex-matched wild-type mice (~30% vs 73%, respectively)
• homozygotes sleep in scattered random patterns, unlike wild-type mice which generally sleep huddled together
• over a period of time, homozygotes tend to loosely huddle in various quandrants of the cage, whereas wild-type mice are more often observed huddled in the same quadrant
• homozygotes build significantly shallower nests from nest building material relative to wild-type controls
• homozygotes tend to sleep on top of intact nestlet material whereas wild-type mice sleep in well-formed, fluffy nests
• however, abnormal nesting behavior is not due to differences in rectal temperatures

nervous system
N
• homozygotes display normal brain histology and synaptic plasticity relative to wild-type mice
• homozygotes display significantly lower levels of acoustic pre-pulse inhibition of both acoustic and tactile startle responses relative to wild-type mice
• homozygotes display significantly lower levels of acoustic pre-pulse inhibition of both acoustic and tactile startle responses relative to wild-type mice

hearing/vestibular/ear
N
• homozygotes exhibit normal stereocilia orientation at E18.5




Genotype
MGI:2654558
cx2
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
• observed between E14.5 and E18.5
• observed between E14.5 and E18.5
• observed between E14.5 and E18.5

embryo
• completely open from midbrain to base of tail at E9.5-E10.5
• fusion observed at face and tail
• mild abnormalities in somite segmentation

skeleton
• extenisve fusion along the vertebral column
• defects more severe than those observed in Dvl2tm1Awb homozygous mutants
• collapsed vertebrae
• defects more severe than those observed in Dvl2tm1Awb homozygous mutants

nervous system
• completely open from midbrain to base of tail at E9.5-E10.5
• fusion observed at face and tail
• increased rows of hair cells within the third of the cochlea near the apex
• at E18.5 misoriented stereocilia bundles, more severe in the medial region than the base of the organ of Corti with approximately 35% misoriented in the two outer rows of outer hair cells, with denser cellular packing

hearing/vestibular/ear
• shorter, wider cochlear ducts
• increased rows of hair cells within the third of the cochlea near the apex
• at E18.5 misoriented stereocilia bundles, more severe in the medial region than the base of the organ of Corti with approximately 35% misoriented in the two outer rows of outer hair cells, with denser cellular packing




Genotype
MGI:3608684
cx3
Allelic
Composition
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2+
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hearing/vestibular/ear
N
• normal stereocilia orientation at E18.5




Genotype
MGI:3715978
cx4
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• the floor plate is expanded
• neural tube fails to close in 100% of embryos
• the stereociliary bundle orientation in the cochlea is disrupted at 100% penetrance
• occasionally misaligned inner hair cells are obverse

hearing/vestibular/ear
• the stereociliary bundle orientation in the cochlea is disrupted at 100% penetrance
• occasionally misaligned inner hair cells are obverse

embryo
• at the 5- through 8- somite stage, the embryo length to width ratio is reduced
• there is no increase in embryo length to width ratio from 5 to 7 somite stage
• the floor plate is expanded
• neural tube fails to close in 100% of embryos
• the notochord is wider




Genotype
MGI:3715991
cx5
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)3Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Tg(Dvl2*/EGFP)3Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• neural tube closure defect is rescued




Genotype
MGI:3715992
cx6
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*/EGFP)4Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Tg(Dvl2*/EGFP)4Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

embryo




Genotype
MGI:3715993
cx7
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Tg(Dvl2*K446M/EGFP)5Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• seen in all mice at E9.5
• at P0, the stereociliary bundle orientation in the cochlea is disrupted and a less recognizable form of stereocilia is observed

hearing/vestibular/ear
• cochlea are wider and shorter
• at P0, the stereociliary bundle orientation in the cochlea is disrupted and a less recognizable form of stereocilia is observed

embryo
• seen in all mice at E9.5




Genotype
MGI:3715988
cx8
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)1Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Tg(Dvl2/EGFP)1Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are restored to fertile adults




Genotype
MGI:3715989
cx9
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2/EGFP)2Awb/?
Genetic
Background
involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Tg(Dvl2/EGFP)2Awb mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• mice are restored to fertile adults




Genotype
MGI:3831928
cx10
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl3tm1Awb/Dvl3tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl3tm1Awb mutation (1 available); any Dvl3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging

nervous system
N
• mice exhibit normal neural tube development




Genotype
MGI:3715980
cx11
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: 13% survive to adulthood on a mixed background

hearing/vestibular/ear
N
• stereociliary bundle orientation is normal in surviving mice

nervous system
• neural tube fails to close in less than 100% of embryos

embryo
• neural tube fails to close in less than 100% of embryos




Genotype
MGI:3715984
cx12
Allelic
Composition
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2+
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no mice are recovered at birth

nervous system
• similar to that observed in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes

embryo
• similar to that observed in Dvl1tm1Awb Dvl2tm1Awb Vangl2Lp triple homozygotes




Genotype
MGI:3715987
cx13
Allelic
Composition
Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Vangl2Lp/Vangl2Lp
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
Vangl2Lp mutation (2 available); any Vangl2 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system

embryo




Genotype
MGI:3715981
cx14
Allelic
Composition
Dvl1tm1Awb/Dvl1+
Dvl2tm1Awb/Dvl2tm1Awb
Genetic
Background
involves: 129S6/SvEvTac * LPT/LeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (30 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (26 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• similar to in Dvl2tm1Awb homozygotes only 50% of expected pups are recovered





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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory