Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
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nervous system
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• spinal cords show a 3- to 4-fold slowing of the locomotor step cycle and lengthening of the burst duration
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Allelic
Composition |
En1tm1Gld/En1tm1Gld
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Genetic
Background |
involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * Swiss Webster |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
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mortality/aging
nervous system
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• decrease in the number of mesencephalic dopaminergic neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
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nervous system
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• at E10.5 axons from En1 expressing neurons form bundles of 3 or more axons within the ventrolateral funiculus unlike in controls where axons do not fasciculate with each other
• at E12 axons from En1 expressing neurons form bundles of 10 or more axons within the ventrolateral funiculus unlike in controls
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• at E10.5 axons from En1 expressing neurons often turn dorsally after entering the ventrolateral funiculus rather than turning rostrally
• at E12 axons from En1 expressing neurons display disorganized trajectories
• at E12.5 axons from En1 expressing neurons are absent from the ventromedial regions of the ventrolateral funiculus with few if any axons adjacent to the medial most motor neurons
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• truncation of the midbrain is seen at E12
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• fewer axons from En1 expressing neurons are present in the medial half of the medial motor column and more axons are present in the lateral half
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limbs/digits/tail
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• limb defects are seen at E12
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cellular
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• at E10.5 axons from En1 expressing neurons form bundles of 3 or more axons within the ventrolateral funiculus unlike in controls where axons do not fasciculate with each other
• at E12 axons from En1 expressing neurons form bundles of 10 or more axons within the ventrolateral funiculus unlike in controls
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• at E10.5 axons from En1 expressing neurons often turn dorsally after entering the ventrolateral funiculus rather than turning rostrally
• at E12 axons from En1 expressing neurons display disorganized trajectories
• at E12.5 axons from En1 expressing neurons are absent from the ventromedial regions of the ventrolateral funiculus with few if any axons adjacent to the medial most motor neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
Ntn1Gt(ST629)Byg mutation
(1 available);
any
Ntn1 mutation
(106 available)
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nervous system
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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cellular
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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• at E11 the majority of En1 expressing neuron ventrally projecting axons are either truncated or turn rostrally before reaching the ventrolateral funiculus
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
Tg(Wnt1-En1)1Amc mutation
(0 available)
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behavior/neurological
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• impaired ability to walk and maintain balance at higher rotarod speeds
• while performance improves with practice mice never match the performance of wild-type controls
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
En2tm1Alj mutation
(1 available);
any
En2 mutation
(104 available)
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nervous system
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• loss of dopaminergic neurons specifically in the substantia nigra pars compacta starting after P0 and continuing until 3 months after birth
• loss is due to apoptosis, not conversion to another cell fate
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• decreased in the release of dopamine from striatal slices following stimulation of the caudate putamen
• however, no defect in release is seen in the nucleus accumbens
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behavior/neurological
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• mice freeze more frequently while swimming compared to En2 null littermate controls
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• between 5 and 11 weeks of age, mice consume less food per day compared to En2 null littermate controls
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• decreased grip strength in an inverted grid assay compared to En2 null littermate controls at 8 months of age but not at 18 months of age
• however, at 18 months of age mice took fewer steps on the grid compared to En2 null littermate controls
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• decrease in forward locomotion in an open field at 18 months of age but not at 8 months of age compared to En2 null littermate controls
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growth/size/body
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• beginning around 5 to 6 weeks of age
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homeostasis/metabolism
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
En2tm1Alj mutation
(1 available);
any
En2 mutation
(104 available)
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mortality/aging
nervous system
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• decrease in the number of mesencephalic dopaminergic neurons
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1tm1Gld mutation
(0 available);
any
En1 mutation
(32 available)
En2tm1Alj mutation
(1 available);
any
En2 mutation
(104 available)
|
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mortality/aging
nervous system
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• decrease in the number of mesencephalic dopaminergic neurons
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Analysis Tools
