Phenotypes associated with this allele

• Allele Symbol: Ren1^tm1Afu
• Allele Name: targeted mutation 1, Akiyoshi Fukamizu
• Allele ID: MGI:2136642
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ren1^tm1Afu/Ren1^tm1Afu	involves: C57BL/6 * CBA	MGI:3699326

Genotype
MGI:3699326

hm1

• Allelic Composition: Ren1^tm1Afu/Ren1^tm1Afu
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Ren1^tm1Afu/Ren1^tm1Afu mice exhibit kidney abnormalities

mortality/aging

postnatal lethality, complete penetrance ( J:59299 )

• die within a week after birth

• subcutaneous injection of saline prevents neonatal death

renal/urinary system

abnormal juxtaglomerular apparatus morphology ( J:59299 )

• exhibit increased innervation of the juxtaglomerular apparatus

abnormal juxtaglomerular cell morphology ( J:59299 )

• juxtaglomerular cells are completely devoid of the storage/secretory granules typically present in wild-type

abnormal macula densa morphology ( J:59299 )

• the macula densa exhibits an increase in macula densa number or a marked accumulation of nuclei as pseudostratified epithelium

hydronephrosis ( J:59299 )

• exhibit dilated renal pelvis

kidney atrophy ( J:59299 )

• atrophy of renal parenchyma from the pallia to the outer strip

polyuria ( J:59299 )

behavior/neurological

polydipsia ( J:59299 )

cardiovascular system

cardiovascular system phenotype ( J:59299 )

N • do not exhibit impaired blood-brain barrier function

vascular smooth muscle hyperplasia ( J:59299 )

• kidney exhibits hyperplastic vascular smooth muscle cells

decreased systemic arterial blood pressure ( J:59299 )

• blood pressure at 8 weeks of age is 20-30 mm Hg lower than in wild-type

decreased systemic arterial diastolic blood pressure ( J:59299 )

decreased systemic arterial systolic blood pressure ( J:59299 )

homeostasis/metabolism

abnormal blood homeostasis ( J:59299 )

• plasma content of angiotensin I is decreased while angiotensinogen levels are increased

decreased circulating renin level ( J:59299 )

• plasma renin activity is decreased to below detectable levels

muscle

vascular smooth muscle hyperplasia ( J:59299 )

• kidney exhibits hyperplastic vascular smooth muscle cells

nervous system

abnormal innervation ( J:59299 )

• exhibit increased innervation of the juxtaglomerular apparatus