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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Krastm3Tyj
targeted mutation 3, Tyler Jacks
MGI:2136169
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Krastm3Tyj/Kras+ involves: 129S4/SvJae MGI:3770517
ht2
Krastm3Tyj/Kras+ involves: 129S4/SvJae * C57BL/6 MGI:3770516
cx3
Ccne1tm1Jro/?
Krastm3Tyj/?
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6) MGI:3586557
cx4
Krastm3Tyj/Kras+
Mir21atm1.1Eno/Mir21atm1.1Eno
involves: 129S/SvEv * 129S4/SvJae * C57BL/6 MGI:5317787
cx5
Krastm3Tyj/Kras+
Pik3catm1Jdo/Pik3catm1Jdo
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J MGI:3716661
cx6
Krastm3Tyj/Kras+
Tg(CAG-Mir21,-EGFP)#Eno/0
involves: 129S4/SvJae * C3H * C57BL/6 MGI:5317786
cx7
Dmtf1tm1Cjs/Dmtf1+
Krastm3Tyj/Kras+
involves: 129S4/SvJae * C57BL/6 MGI:3770617
cx8
Dmtf1tm1Cjs/Dmtf1tm1Cjs
Krastm3Tyj/Kras+
involves: 129S4/SvJae * C57BL/6 MGI:3770618


Genotype
MGI:3770517
ht1
Allelic
Composition
Krastm3Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mean age at death is ~250 days on pure 129/Sv background compared to 200 days on mixed background (J:68981)
• Background Sensitivity: mean age at death is ~250 days on pure 129/Sv background compared to 200 days on mixed background (J:68981)

tumorigenesis
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)
• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background (J:68981)
• Background Sensitivity: ~30% of animals develop thymic lymphoma; incidence is higher than on pure 129/Sv background (J:68981)
• 100% of mice examined at 3-4 months of age have developed lung tumors (J:119477)
• 100% of mice examined at 3-4 months of age have developed lung tumors (J:119477)

integument
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)
• Background Sensitivity: about 40% of mice develop skin papillomas, with slightly higher incidence than on mixed 129 and C57BL/6 background (J:68981)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:68981




Genotype
MGI:3770516
ht2
Allelic
Composition
Krastm3Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: mean age at death is ~200 days (J:68981)
• Background Sensitivity: mean age at death is ~200 days (J:68981)

tumorigenesis
• all animals at time of death/sacrifice have extensive tumor burden (J:68981)
• mice display a more rapid tumor phenotype than Krastm2Tyj heterozygotes (J:68981)
• all animals at time of death/sacrifice have extensive tumor burden (J:68981)
• mice display a more rapid tumor phenotype than Krastm2Tyj heterozygotes (J:68981)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~40% of animals) (J:68981)
• Background Sensitivity: animals are prone to thymic lymphomas (seen in ~40% of animals) (J:68981)
• 100% of animals show multifocal tumors at time of death/sacrifice (J:68981)
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death (J:68981)
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium (J:68981)
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs (J:68981)
• 100% of animals show multifocal tumors at time of death/sacrifice (J:68981)
• tumors are detectable at 1 week of age as small pleural nodules; multiplicity and size of tumors increases with age, and ultimately result in respiratory distress and death (J:68981)
• tumors range from mild hyperplasia/dysplasia to overt carcinoma; small lesions consist of hyperplastic alveolar epithelium (J:68981)
• in older mice, infrequent metastases to thoracic lymph nodes, the kidney and other visceral organs (J:68981)
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation (J:68981)
• as lesions enlarge, they form small alveolar adenomas; some show areas of glandular differentiation (J:68981)
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma (J:68981)
• 5-10% of tumors have features of well-differentiated human papillary adenocarcinoma (J:68981)

digestive/alimentary system
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)

endocrine/exocrine glands
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)
• mutants have multiple aberrant crypt foci (ACF) of the colon (J:68981)

integument
• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)
• Background Sensitivity: animals are prone to skin papillomas (seen in ~20% of animals); tumors typically arising on ears and snout are predominantly pedunculated and show limited tendency to progress to squamous cell carcinoma (J:68981)

Mouse Models of Human Disease
OMIM ID Ref(s)
Lung Cancer 211980 J:68981




Genotype
MGI:3586557
cx3
Allelic
Composition
Ccne1tm1Jro/?
Krastm3Tyj/?
Genetic
Background
either: (involves: 129S4/SvJaeSor) or (involves: 129S4/SvJaeSor * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccne1tm1Jro mutation (0 available); any Ccne1 mutation (3 available)
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival is reduced to 160 days compared to 260 days for mice homozygous for Kras alone (J:99695)
• mean survival is reduced to 160 days compared to 260 days for mice homozygous for Kras alone (J:99695)

cellular
• 2 of 6 tumors from double mutants display significant gains or losses of whole chromosomes while no gains or losses of whole chromosomes are seen in Kras homozygotes (J:99695)
• 2 of 6 tumors from double mutants display significant gains or losses of whole chromosomes while no gains or losses of whole chromosomes are seen in Kras homozygotes (J:99695)




Genotype
MGI:5317787
cx4
Allelic
Composition
Krastm3Tyj/Kras+
Mir21atm1.1Eno/Mir21atm1.1Eno
Genetic
Background
involves: 129S/SvEv * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
Mir21atm1.1Eno mutation (0 available); any Mir21a mutation (6 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• unlike Krastm3Tyj heterozygotes, mice do not develop skin papillomas or lung adenomcarcinomas (J:164198)
• unlike Krastm3Tyj heterozygotes, mice do not develop skin papillomas or lung adenomcarcinomas (J:164198)
• mice exhibit decreased total tumor area relative to lung area compared with Krastm3Tyj heterozygotes (J:164198)
• however, tumor cell proliferation is the same as in Krastm3Tyj heterozygotes (J:164198)
• mice exhibit decreased total tumor area relative to lung area compared with Krastm3Tyj heterozygotes (J:164198)
• however, tumor cell proliferation is the same as in Krastm3Tyj heterozygotes (J:164198)
• mice develop fewer lung adenoma than in Krastm3Tyj heterozygotes (J:164198)
• mice develop fewer lung adenoma than in Krastm3Tyj heterozygotes (J:164198)
• fewer than in Krastm3Tyj heterozygotes (J:164198)
• fewer than in Krastm3Tyj heterozygotes (J:164198)
• mice develop fewer thymic lymphoma, lung hyperplasia and lung adenomas than in Krastm3Tyj heterozygotes (J:164198)
• mice develop fewer thymic lymphoma, lung hyperplasia and lung adenomas than in Krastm3Tyj heterozygotes (J:164198)
• fewer lung adenoma than in Krastm3Tyj heterozygotes (J:164198)
• fewer lung adenoma than in Krastm3Tyj heterozygotes (J:164198)

respiratory system
• mice develop fewer lung hyperplasia than in Krastm3Tyj heterozygotes (J:164198)
• mice develop fewer lung hyperplasia than in Krastm3Tyj heterozygotes (J:164198)




Genotype
MGI:3716661
cx5
Allelic
Composition
Krastm3Tyj/Kras+
Pik3catm1Jdo/Pik3catm1Jdo
Genetic
Background
involves: 129S4/SvJae * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
Pik3catm1Jdo mutation (1 available); any Pik3ca mutation (15 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
• zero to two visible tumors are found compared to forty or so tumors in Krastm3Tyj mice (J:122866)
• apoptotic rates in small lesions are increased compared to in Krastm3Tyj mice (J:122866)
• zero to two visible tumors are found compared to forty or so tumors in Krastm3Tyj mice (J:122866)
• apoptotic rates in small lesions are increased compared to in Krastm3Tyj mice (J:122866)
• one mouse did not show any evidence of lung tumor formation up to 6 months of age (J:122866)
• one mouse did not show any evidence of lung tumor formation up to 6 months of age (J:122866)




Genotype
MGI:5317786
cx6
Allelic
Composition
Krastm3Tyj/Kras+
Tg(CAG-Mir21,-EGFP)#Eno/0
Genetic
Background
involves: 129S4/SvJae * C3H * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
Tg(CAG-Mir21,-EGFP)#Eno mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice exhibit premature death compared with wild-type mice (J:164198)
• however, mice exhibit the same mortality as Krastm3Tyj heterozygotes (J:164198)
• mice exhibit premature death compared with wild-type mice (J:164198)
• however, mice exhibit the same mortality as Krastm3Tyj heterozygotes (J:164198)

tumorigenesis
• increased proliferation of tumor cells compared with tumor cells from Krastm3Tyj heterozygotes (J:164198)
• increased proliferation of tumor cells compared with tumor cells from Krastm3Tyj heterozygotes (J:164198)
• at 18 weeks compared with Krastm3Tyj heterozygotes (J:164198)
• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Krastm3Tyj heterozygotes (J:164198)
• at 18 weeks compared with Krastm3Tyj heterozygotes (J:164198)
• mice develop increased incidence of all tumor grades without increasing the rate of conversion to adenocarcinoma compared with Krastm3Tyj heterozygotes (J:164198)
• of thymic tumors compared with Krastm3Tyj heterozygotes (J:164198)
• of thymic tumors compared with Krastm3Tyj heterozygotes (J:164198)




Genotype
MGI:3770617
cx7
Allelic
Composition
Dmtf1tm1Cjs/Dmtf1+
Krastm3Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1tm1Cjs mutation (1 available); any Dmtf1 mutation (33 available)
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras+/-, Dmtf1-sufficient mice (J:126002)
• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras+/-, Dmtf1-sufficient mice (J:126002)

tumorigenesis
• 10-20% of animals develop tail papillomas (J:126002)
• 10-20% of animals develop tail papillomas (J:126002)
• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in KrasLA+/-, Dmtf1-sufficient mice (J:126002)
• <5% of animals show distant metastases (liver/intr-abdominal or leg) of lung tumors, while no metastases are observed in KrasLA+/-, Dmtf1-sufficient mice (J:126002)
• ~35% of mice develop thymic lymphomas (J:126002)
• ~35% of mice develop thymic lymphomas (J:126002)
• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion (J:126002)
• ~50% of largest tumors are well, moderately, or poorly differentiated adenocarcinomas, with signs of intrabronchial or intravascular invasion (J:126002)
• all mice develop lung adenomas or lung adenocarcinomas (J:126002)
• all mice develop lung adenomas or lung adenocarcinomas (J:126002)
• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in KrasLA+/- single mutants (J:126002)
• number of tumor nodules increase as animals become sick, with trend to increased nodule size (J:126002)
• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in KrasLA+/- single mutants (J:126002)
• number of tumor nodules increase as animals become sick, with trend to increased nodule size (J:126002)
• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice (J:126002)
• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice (J:126002)

integument
• 10-20% of animals develop tail papillomas (J:126002)
• 10-20% of animals develop tail papillomas (J:126002)




Genotype
MGI:3770618
cx8
Allelic
Composition
Dmtf1tm1Cjs/Dmtf1tm1Cjs
Krastm3Tyj/Kras+
Genetic
Background
involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmtf1tm1Cjs mutation (1 available); any Dmtf1 mutation (33 available)
Krastm3Tyj mutation (2 available); any Kras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras+/-, Dmtf1-sufficient mice (J:126002)
• mean survival time of double mutants is 21 weeks compared to 35 weeks for Kras+/-, Dmtf1-sufficient mice (J:126002)

tumorigenesis
• 10-20% of animals develop tail papillomas (J:126002)
• 10-20% of animals develop tail papillomas (J:126002)
• ~20% of mice develop thymic lymphomas (J:126002)
• ~20% of mice develop thymic lymphomas (J:126002)
• all mice develop lung adenomas or lung adenocarcinomas (J:126002)
• all mice develop lung adenomas or lung adenocarcinomas (J:126002)
• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in KrasLA+/- single mutants (J:126002)
• number of tumor nodules increase as animals become sick, with trend to increased nodule size (J:126002)
• greater than 50% of mice develop lung carcinomas by 40 weeks of age, and tumors are significantly larger than those found in KrasLA+/- single mutants (J:126002)
• number of tumor nodules increase as animals become sick, with trend to increased nodule size (J:126002)
• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice (J:126002)
• tumorigenesis is accelerated relative to heterozygous Kras, wild-type Dmtf1 mice (J:126002)

integument
• 10-20% of animals develop tail papillomas (J:126002)
• 10-20% of animals develop tail papillomas (J:126002)





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory