growth/size/body
• about 70% of controls
(J:52438)
• about 70% of controls
(J:52438)

limbs/digits/tail
• humeri lengths are 76% and 70% of wildtype at P20 and P90, respectively
(J:52438)
• humeri lengths are 76% and 70% of wildtype at P20 and P90, respectively
(J:52438)

• femur lengths are 68% and 65% of wildtype at P20 and P90, respectively
(J:52438)
• femur lengths are 68% and 65% of wildtype at P20 and P90, respectively
(J:52438)

• tails grow more slowly and stay at about 70% of controls
(J:52438)
• tails grow more slowly and stay at about 70% of controls
(J:52438)

skeleton
• shortening of the length of all bones formed by endochondral ossification
(J:52438)
• shortening of the length of all bones formed by endochondral ossification
(J:52438)

• humeri lengths are 76% and 70% of wildtype at P20 and P90, respectively
(J:52438)
• humeri lengths are 76% and 70% of wildtype at P20 and P90, respectively
(J:52438)

• femur lengths are 68% and 65% of wildtype at P20 and P90, respectively
(J:52438)
• femur lengths are 68% and 65% of wildtype at P20 and P90, respectively
(J:52438)

• maturation zone is smaller and very disorganized
(J:52438)
• maturation zone is smaller and very disorganized
(J:52438)

• proliferation zone is smaller and very disorganized
(J:52438)
• proliferation zone is smaller and very disorganized
(J:52438)

• wider growth plates due to the expansion of the zone of resting chondrocytes
(J:52438)
• wider growth plates due to the expansion of the zone of resting chondrocytes
(J:52438)

• decrease in the interpedicular distances between vertebral bodies that is proportional to the reduction in the lengths of vertebral bodies
(J:52438)
• decrease in the interpedicular distances between vertebral bodies that is proportional to the reduction in the lengths of vertebral bodies
(J:52438)

• spinal column lengths are 83% of wildtype
(J:52438)
• spinal column lengths are 83% of wildtype
(J:52438)

• activity of proliferating chondrocytes is reduced in the growth plate
(J:52438)
• activity of proliferating chondrocytes is reduced in the growth plate
(J:52438)

Mouse Models of Human Disease 
OMIM ID  Ref(s)  
Achondroplasia; ACH  100800  J:52438  
NOT  Thanatophoric Dysplasia, Type I; TD1  187600  J:52438 